PMID- 26447089
OWN - NLM
STAT- MEDLINE
DCOM- 20161103
LR  - 20161230
IS  - 1880-3873 (Electronic)
IS  - 1340-3478 (Linking)
VI  - 23
IP  - 2
DP  - 2016
TI  - Postprandial Paraoxonase 1 Activity Following Consumption of Recommended Amounts 
      of Mixed Meals in Healthy Males.
PG  - 225-32
LID - 10.5551/jat.30585 [doi]
AB  - AIM: Postprandial lipid level increases induce oxidative stress, which is 
      involved in atherogenesis. The antioxidant properties of paraoxonase 1 (PON1) 
      have attracted attention. However, changes in postprandial PON1 levels differ 
      across prior studies, and changes in PON1 lactonase activity, potentially 
      relevant to PON1 physiology, after the consumption of ordinary meals are unknown. 
      Herein we evaluated postprandial serum lipid levels and PON1 changes following 
      mixed-meal consumption of the amounts recommended for ordinary meals. METHODS: 
      Nine healthy male volunteers consumed three different meals in a randomized 
      cross-over design. The test meals were as follows: S, white rice; SMF, S with 
      fat-containing protein-rich main dishes; and SMFV: SMF with vegetable dishes. The 
      serum lipid concentrations and PON1 lactonase and arylesterase activities were 
      determined during a three-hour period after the consumption of these meals. 
      RESULTS: The postprandial triglyceride levels were higher after consuming the SMF 
      and SMFV meals than after consuming the S meal. Despite postprandial high-density 
      lipoprotein cholesterol being unchanged, PON1 lactonase activity was decreased, 
      while PON1 arylesterase activity was increased in the postprandial state after 
      all test meals. Postprandial changes in lactonase and arylesterase activities did 
      not differ among the test meals. CONCLUSIONS: Inverse changes in PON1 lactonase 
      and arylesterase activities were observed after consuming recommended ordinary 
      meals. This observation provides useful information for choosing PON1 species as 
      postprandial markers.
FAU - Kameyama, Noriko
AU  - Kameyama N
AD  - Department of Food and Nutrition, Faculty of Human Sciences and Design, Japan 
      Women's University.
FAU - Maruyama, Chizuko
AU  - Maruyama C
FAU - Kotani, Kazuhiko
AU  - Kotani K
FAU - Caccavello, Russell
AU  - Caccavello R
FAU - Gugliucci, Alejandro
AU  - Gugliucci A
FAU - Matsui, Sadako
AU  - Matsui S
FAU - Araki, Risa
AU  - Araki R
FAU - Maruyama, Taro
AU  - Maruyama T
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20151008
PL  - Japan
TA  - J Atheroscler Thromb
JT  - Journal of atherosclerosis and thrombosis
JID - 9506298
RN  - 0 (Biomarkers)
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Lipoproteins, HDL)
RN  - EC 3.1.1.- (Carboxylic Ester Hydrolases)
RN  - EC 3.1.1.17 (gluconolactonase)
RN  - EC 3.1.1.2 (arylesterase)
RN  - EC 3.1.8.1 (Aryldialkylphosphatase)
RN  - EC 3.1.8.1 (PON1 protein, human)
SB  - IM
MH  - Adult
MH  - Aryldialkylphosphatase/*blood
MH  - Atherosclerosis/blood/enzymology/epidemiology
MH  - Biomarkers/*blood
MH  - Carboxylic Ester Hydrolases/*metabolism
MH  - Cholesterol, HDL/blood
MH  - Cross-Over Studies
MH  - Follow-Up Studies
MH  - Humans
MH  - Japan/epidemiology
MH  - Lipoproteins, HDL/blood
MH  - Male
MH  - *Meals
MH  - Middle Aged
MH  - *Postprandial Period
MH  - Prognosis
MH  - Risk Factors
MH  - Single-Blind Method
EDAT- 2015/10/09 06:00
MHDA- 2016/11/04 06:00
CRDT- 2015/10/09 06:00
PHST- 2015/10/09 06:00 [entrez]
PHST- 2015/10/09 06:00 [pubmed]
PHST- 2016/11/04 06:00 [medline]
AID - 10.5551/jat.30585 [doi]
PST - ppublish
SO  - J Atheroscler Thromb. 2016;23(2):225-32. doi: 10.5551/jat.30585. Epub 2015 Oct 8.