PMID- 26450157
OWN - NLM
STAT- MEDLINE
DCOM- 20160817
LR  - 20181113
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 5
DP  - 2015 Oct 9
TI  - Cord Blood 25-hydroxyvitamin D and Fetal Growth in the China-Anhui Birth Cohort 
      Study.
PG  - 14930
LID - 10.1038/srep14930 [doi]
LID - 14930
AB  - We determined the association of cord blood 25-hydroxyvitamin D [25(OH)D] with 
      birth weight and the risk of small for gestational age (SGA). As part of the 
      China-Anhui Birth Cohort (C-ABC) study, we measured cord blood levels of 25(OH)D 
      in 1491 neonates in Hefei, China. The data on maternal sociodemographic 
      characteristics, health status, lifestyle, birth outcomes were prospectively 
      collected. Multiple regression models were used to estimate the association of 
      25(OH)D levels with birth weight and the risk of SGA. Compared with neonates in 
      the lowest decile of cord blood 25(OH)D levels, neonates in four deciles (the 
      fourth, fifth, sixth and seventh deciles) had significantly increased birth 
      weight and decreased risk of SGA. Multiple linear regression models showed that 
      per 10 nmol/L increase in cord blood 25(OH)D, birth weight increased by 61.0 g 
      (95% CI: 31.9, 89.9) at concentrations less than 40 nmol/L, and then decreased by 
      68.5 g (95% CI: -110.5, -26.6) at concentrations from 40 to 70 nmol/L. This study 
      provides the first epidemiological evidence that there was an inverted U shaped 
      relationship between neonatal vitamin D status and fetal growth, and the risk of 
      SGA reduced at moderate concentration.
FAU - Zhu, Peng
AU  - Zhu P
AD  - Department of Maternal, Child &Adolescent Health, Anhui Medical University, 
      Hefei, China.
AD  - Anhui Provincial Key Laboratory of Population Health &Aristogenics, Anhui Medical 
      University, Hefei, China.
AD  - School of Public Health and social work, and Institute of Health and Biomedical 
      Innovation, Queensland University of Technology, Kelvin Grove, Qld, Australia.
FAU - Tong, Shi-lu
AU  - Tong SL
AD  - Department of Maternal, Child &Adolescent Health, Anhui Medical University, 
      Hefei, China.
AD  - School of Public Health and social work, and Institute of Health and Biomedical 
      Innovation, Queensland University of Technology, Kelvin Grove, Qld, Australia.
FAU - Hu, Wen-biao
AU  - Hu WB
AD  - School of Public Health and social work, and Institute of Health and Biomedical 
      Innovation, Queensland University of Technology, Kelvin Grove, Qld, Australia.
FAU - Hao, Jia-hu
AU  - Hao JH
AD  - Department of Maternal, Child &Adolescent Health, Anhui Medical University, 
      Hefei, China.
AD  - Anhui Provincial Key Laboratory of Population Health &Aristogenics, Anhui Medical 
      University, Hefei, China.
FAU - Tao, Rui-xue
AU  - Tao RX
AD  - Department of Gynecology and Obstetrics, Hefei First People's Hospital, Hefei, 
      China.
FAU - Huang, Kun
AU  - Huang K
AD  - Department of Maternal, Child &Adolescent Health, Anhui Medical University, 
      Hefei, China.
AD  - Anhui Provincial Key Laboratory of Population Health &Aristogenics, Anhui Medical 
      University, Hefei, China.
FAU - Mou, Zhe
AU  - Mou Z
AD  - Shanghai Key Laboratory of Meteorology and Health, Shanghai, China.
FAU - Zhou, Qi-fan
AU  - Zhou QF
AD  - Department of Maternal, Child &Adolescent Health, Anhui Medical University, 
      Hefei, China.
FAU - Jiang, Xiao-min
AU  - Jiang XM
AD  - Department of Gynecology and Obstetrics, Hefei Maternal and Child Health 
      Hospital, Hefei, China.
FAU - Tao, Fang-biao
AU  - Tao FB
AD  - Department of Maternal, Child &Adolescent Health, Anhui Medical University, 
      Hefei, China.
AD  - Anhui Provincial Key Laboratory of Population Health &Aristogenics, Anhui Medical 
      University, Hefei, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151009
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 1406-16-2 (Vitamin D)
RN  - A288AR3C9H (25-hydroxyvitamin D)
SB  - IM
MH  - Birth Weight/*physiology
MH  - China
MH  - Cohort Studies
MH  - Female
MH  - Fetal Blood/*chemistry
MH  - Fetal Development/*physiology
MH  - Fetal Weight/physiology
MH  - Gestational Age
MH  - Humans
MH  - Infant, Newborn
MH  - Infant, Small for Gestational Age/*blood
MH  - Linear Models
MH  - Pregnancy
MH  - Prenatal Care/methods/statistics & numerical data
MH  - Risk Factors
MH  - Vitamin D/*analogs & derivatives/blood
PMC - PMC4598849
EDAT- 2015/10/10 06:00
MHDA- 2016/08/18 06:00
PMCR- 2015/10/09
CRDT- 2015/10/10 06:00
PHST- 2015/02/17 00:00 [received]
PHST- 2015/09/09 00:00 [accepted]
PHST- 2015/10/10 06:00 [entrez]
PHST- 2015/10/10 06:00 [pubmed]
PHST- 2016/08/18 06:00 [medline]
PHST- 2015/10/09 00:00 [pmc-release]
AID - srep14930 [pii]
AID - 10.1038/srep14930 [doi]
PST - epublish
SO  - Sci Rep. 2015 Oct 9;5:14930. doi: 10.1038/srep14930.