PMID- 26452299
OWN - NLM
STAT- MEDLINE
DCOM- 20170919
LR  - 20181113
IS  - 1552-9924 (Electronic)
IS  - 0091-6765 (Print)
IS  - 0091-6765 (Linking)
VI  - 124
IP  - 5
DP  - 2016 May
TI  - Cross-sectional Associations between Exposure to Persistent Organic Pollutants 
      and Leukocyte Telomere Length among U.S. Adults in NHANES, 2001-2002.
PG  - 651-8
LID - 10.1289/ehp.1510187 [doi]
AB  - BACKGROUND: Exposure to persistent organic pollutants (POPs) such as dioxins, 
      furans, and polychlorinated biphenyls (PCBs) may influence leukocyte telomere 
      length (LTL), a biomarker associated with chronic disease. In vitro research 
      suggests dioxins may bind to the aryl hydrocarbon receptor (AhR) and induce 
      telomerase activity, which elongates LTL. However, few epidemiologic studies have 
      investigated associations between POPs and LTL. OBJECTIVES: We examined the 
      association between 18 PCBs, 7 dioxins, and 9 furans and LTL among 1,330 U.S. 
      adults from NHANES 2001-2002. METHODS: We created three summed POP metrics based 
      on toxic equivalency factor (TEF), a potency measure including affinity for the 
      AhR: a) non-dioxin-like PCBs (composed of 10 non-dioxin-like PCBs; no AhR 
      affinity and no TEF); b) non-ortho PCBs (composed of 2 non-ortho-substituted PCBs 
      with high TEFs); and c) toxic equivalency (TEQ) (composed of 7 dioxins, 9 furans, 
      2 non-ortho-substituted PCBs, and 6 mono-ortho-substituted PCBs; weighted by 
      TEF). We tested the association between each metric and LTL using linear 
      regression, adjusting for demographics, blood cell count and distribution, and 
      another metric with a different TEF (i.e., non-ortho PCBs and TEQ adjusted for 
      non-dioxin-like PCBs; non-dioxin-like PCBs adjusted for non-ortho PCBs). RESULTS: 
      In adjusted models, each doubling of serum concentrations of non-ortho PCBs and 
      TEQ was associated with 3.74% (95% CI: 2.10, 5.40) and 5.29% (95% CI: 1.66, 9.05) 
      longer LTLs, respectively. Compared with the lowest quartile, the highest 
      quartile of exposure was associated with 9.16% (95% CI: 2.96, 15.73) and 7.84% 
      (95% CI: -0.53, 16.92) longer LTLs, respectively. Non-dioxin-like PCBs were not 
      associated with LTL. CONCLUSIONS: POPs with high TEFs and AhR affinity were 
      associated with longer LTL. Because many dioxin-associated cancers are also 
      associated with longer LTL, these results may provide insight into the mechanisms 
      underlying PCB- and dioxin-related carcinogenesis. CITATION: Mitro SD, Birnbaum 
      LS, Needham BL, Zota AR. 2016. Cross-sectional associations between exposure to 
      persistent organic pollutants and leukocyte telomere length among U.S. adults in 
      NHANES, 2001-2002. Environ Health Perspect 
      124:651-658; http://dx.doi.org/10.1289/ehp.1510187.
FAU - Mitro, Susanna D
AU  - Mitro SD
AD  - Department of Environmental and Occupational Health, Milken Institute School of 
      Public Health, George Washington University, Washington DC, USA.
FAU - Birnbaum, Linda S
AU  - Birnbaum LS
FAU - Needham, Belinda L
AU  - Needham BL
FAU - Zota, Ami R
AU  - Zota AR
LA  - eng
GR  - R00 ES019881/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, N.I.H., Intramural
DEP - 20151009
PL  - United States
TA  - Environ Health Perspect
JT  - Environmental health perspectives
JID - 0330411
RN  - 0 (Benzofurans)
RN  - 0 (Dioxins)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Polychlorinated Dibenzodioxins)
RN  - 0 (Receptors, Aryl Hydrocarbon)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Benzofurans
MH  - Cross-Sectional Studies
MH  - Dioxins
MH  - Environmental Exposure/*statistics & numerical data
MH  - Environmental Pollutants/*toxicity
MH  - Humans
MH  - *Leukocytes
MH  - Nutrition Surveys
MH  - Polychlorinated Biphenyls/toxicity
MH  - Polychlorinated Dibenzodioxins
MH  - Receptors, Aryl Hydrocarbon
MH  - *Telomere
MH  - United States
PMC - PMC4858394
COIS- The authors declare that they have no competing financial interests, and that 
      their freedom to design, conduct, interpret, and publish research was not 
      compromised by any controlling sponsor.
EDAT- 2015/10/10 06:00
MHDA- 2017/09/20 06:00
PMCR- 2016/05/01
CRDT- 2015/10/10 06:00
PHST- 2015/05/07 00:00 [received]
PHST- 2015/10/05 00:00 [accepted]
PHST- 2015/10/10 06:00 [entrez]
PHST- 2015/10/10 06:00 [pubmed]
PHST- 2017/09/20 06:00 [medline]
PHST- 2016/05/01 00:00 [pmc-release]
AID - ehp.1510187 [pii]
AID - 10.1289/ehp.1510187 [doi]
PST - ppublish
SO  - Environ Health Perspect. 2016 May;124(5):651-8. doi: 10.1289/ehp.1510187. Epub 
      2015 Oct 9.