PMID- 26453024
OWN - NLM
STAT- MEDLINE
DCOM- 20161005
LR  - 20191113
IS  - 2212-3334 (Electronic)
IS  - 1872-2148 (Linking)
VI  - 9
IP  - 2
DP  - 2015
TI  - Biology and Regulatory Roles of Nuclear Lamins in Cellular Function and 
      Dysfunction.
PG  - 111-20
AB  - Nuclear lamins, namely lamins A, B and C, surround the nucleoplasmic contents in 
      a meshlike network called the nuclear lamina. These intermediate filaments 
      provide a structural framework to the nuclear envelope (NE), play a role in 
      arrangement of the chromatin within the nucleus, in DNA replication and also 
      participate in DNA damage repair. In order for lamins to be involved in these 
      important nuclear processes and to be functionally active, they undergo a series 
      of post-translational modifications (farnesylation, endoproteolytic cleavage, 
      carboxylmethylation etc.), of which farnesylation is the most studied. Improper 
      farnesylation of lamin proteins, especially lamin A, leads to a number of 
      diseases affecting the striated muscle (e.g. Emery- Dreifuss Muscular Dystrophy, 
      Dilated Cardiomyopathy), adipose tissue (e.g. Dunnigan-type familial partial 
      lipodystrophy) and could result in abnormal senescence and growth deformities 
      (e.g. Progeria syndrome); these are referred to as laminopathies. Despite the 
      existing literature and evidence regarding functions of lamins and diseases 
      associated with abnormal lamin processing, a lot remains to be understood in 
      regards to lamin biology and their role as potential therapeutic targets. In this 
      brief review, we have attempted to summarize the roles of lamins in physiology 
      and pathology of the cell and in type 2 diabetes mellitus [T2DM] and also 
      enlisted patents on methods, systems and devices developed for improving 
      pancreatic beta cell function in diabetes mellitus.
FAU - Khadija, Syeda G
AU  - Khadija SG
FAU - Chen, Fei
AU  - Chen F
FAU - Hadden, Timothy
AU  - Hadden T
FAU - Commissaris, Randall L
AU  - Commissaris RL
FAU - Kowluru, Anjaneyulu
AU  - Kowluru A
AD  - B4237, Research Service, John D. Dingell VA Medical Center, 4646 John R, Detroit, 
      MI 48201; USA. akowluru@med.wayne.edu.
LA  - eng
GR  - DK94201/DK/NIDDK NIH HHS/United States
GR  - EY022230/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Review
PL  - United Arab Emirates
TA  - Recent Pat Endocr Metab Immune Drug Discov
JT  - Recent patents on endocrine, metabolic & immune drug discovery
JID - 101299743
RN  - 0 (Chromatin)
RN  - 0 (Lamins)
SB  - IM
MH  - Animals
MH  - Chromatin/chemistry
MH  - DNA Replication
MH  - Endoplasmic Reticulum Stress
MH  - Humans
MH  - Insulin-Secreting Cells/physiology
MH  - Lamins/*physiology
MH  - Mutation
MH  - Nuclear Envelope/physiology
MH  - Prenylation
EDAT- 2015/10/11 06:00
MHDA- 2016/10/07 06:00
CRDT- 2015/10/11 06:00
PHST- 2015/09/08 00:00 [received]
PHST- 2015/10/01 00:00 [revised]
PHST- 2015/10/09 00:00 [accepted]
PHST- 2015/10/11 06:00 [entrez]
PHST- 2015/10/11 06:00 [pubmed]
PHST- 2016/10/07 06:00 [medline]
AID - EMI-EPUB-70976 [pii]
AID - 10.2174/1872214809666151009120402 [doi]
PST - ppublish
SO  - Recent Pat Endocr Metab Immune Drug Discov. 2015;9(2):111-20. doi: 
      10.2174/1872214809666151009120402.