PMID- 26453801
OWN - NLM
STAT- MEDLINE
DCOM- 20160630
LR  - 20221207
IS  - 1873-5487 (Electronic)
IS  - 0188-4409 (Linking)
VI  - 46
IP  - 7
DP  - 2015 Oct
TI  - Vitamin D Receptor Genetic Polymorphism Is Significantly Associated with Risk of 
      Type 2 Diabetes Mellitus in Chinese Han Population.
PG  - 572-9
LID - S0188-4409(15)00249-0 [pii]
LID - 10.1016/j.arcmed.2015.09.006 [doi]
AB  - BACKGROUND AND AIMS: We investigated the effect of vitamin D receptor (VDR) gene 
      polymorphism on the risk of type 2 diabetes mellitus (T2DM) in a Chinese Han 
      population. METHODS: Three tagSNPs (rs11574129, rs2228570 and rs739837) were 
      genotyped using TaqMan assays in a case-control study including 669 cases with 
      T2DM, 1084 individuals with impaired fasting glucose (IFG) and 1,961 controls 
      with normal fasting glucose. Multiple logistic regression was applied to analyze 
      the association of SNPs and the risk of diabetes by adjusting for covariates 
      including age, sex, body mass index (BMI) and smoking. General linear model (GLM) 
      was applied to compare fasting blood glucose levels between genotypes and 
      adjusted for confounding factors. RESULTS: The results showed that rs739837 was 
      significantly associated with increased risk of T2DM in additive model (OR = 
      1.166, 95% CI 1.017-1.337, p = 0.028) and dominant (OR = 1.166, 95% CI 
      1.017-1.337, p = 0.002) model. Stratified analysis showed that rs739837 and 
      rs2228570 were, respectively, correlated with T2DM in females and males. 
      Significant associations were found between three SNPs and T2DM in the population 
      <55 years of age. SNPs (rs739837, rs11574129) showed significant associations 
      with T2DM in the smoking population. Quantitative trait analysis indicated that 
      the CC group of rs2228570 has lower fasting glucose than TT/TC genotype group in 
      controls. CONCLUSIONS: This study provides further evidence that rs739837 in the 
      VDR gene is associated with increased risk of T2DM in a Chinese Han population.
CI  - Copyright (c) 2015 IMSS. Published by Elsevier Inc. All rights reserved.
FAU - Jia, Jian
AU  - Jia J
AD  - Department of Geriatric Medicine, The First Affiliated Hospital, Nanjing Medical 
      University, Nanjing, China.
FAU - Ding, Haixia
AU  - Ding H
AD  - Department of Geriatric Medicine, The First Affiliated Hospital, Nanjing Medical 
      University, Nanjing, China.
FAU - Yang, Keming
AU  - Yang K
AD  - Department of Geriatric Medicine, The First Affiliated Hospital, Nanjing Medical 
      University, Nanjing, China.
FAU - Mao, Lina
AU  - Mao L
AD  - Department of Geriatric Medicine, The First Affiliated Hospital, Nanjing Medical 
      University, Nanjing, China.
FAU - Zhao, Hailong
AU  - Zhao H
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Nanjing 
      Medical University, Nanjing, China.
FAU - Zhan, Yiyang
AU  - Zhan Y
AD  - Department of Geriatric Medicine, The First Affiliated Hospital, Nanjing Medical 
      University, Nanjing, China. Electronic address: yiyangzhan@sina.com.
FAU - Shen, Chong
AU  - Shen C
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Nanjing 
      Medical University, Nanjing, China. Electronic address: sc@njmu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151009
PL  - United States
TA  - Arch Med Res
JT  - Archives of medical research
JID - 9312706
RN  - 0 (Blood Glucose)
RN  - 0 (Receptors, Calcitriol)
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Asian People/genetics
MH  - Blood Glucose/genetics
MH  - Body Mass Index
MH  - Case-Control Studies
MH  - China/epidemiology
MH  - Diabetes Mellitus, Type 2/*epidemiology/*genetics
MH  - Female
MH  - Genetic Association Studies
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Phenotype
MH  - Polymorphism, Single Nucleotide
MH  - Prediabetic State/complications
MH  - Quantitative Trait Loci
MH  - Receptors, Calcitriol/*genetics
MH  - Sex Factors
OTO - NOTNLM
OT  - Impaired fasting glucose
OT  - Polymorphism
OT  - Type 2 diabetes mellitus
OT  - Vitamin D receptor
EDAT- 2015/10/11 06:00
MHDA- 2016/07/01 06:00
CRDT- 2015/10/11 06:00
PHST- 2015/04/25 00:00 [received]
PHST- 2015/09/30 00:00 [accepted]
PHST- 2015/10/11 06:00 [entrez]
PHST- 2015/10/11 06:00 [pubmed]
PHST- 2016/07/01 06:00 [medline]
AID - S0188-4409(15)00249-0 [pii]
AID - 10.1016/j.arcmed.2015.09.006 [doi]
PST - ppublish
SO  - Arch Med Res. 2015 Oct;46(7):572-9. doi: 10.1016/j.arcmed.2015.09.006. Epub 2015 
      Oct 9.