PMID- 26453826 OWN - NLM STAT- MEDLINE DCOM- 20161005 LR - 20161230 IS - 1096-1208 (Electronic) IS - 0882-4010 (Linking) VI - 89 DP - 2015 Dec TI - Subversion of mouse dendritic cell subset function by bacterial pathogens. PG - 140-9 LID - S0882-4010(15)00164-3 [pii] LID - 10.1016/j.micpath.2015.10.004 [doi] AB - Dendritic cells (DCs) play an important role as sentinels of the immune system in initiating and controlling the quality of adaptive immune responses. Located at entry points of the host they can sense and alert the body from dangers such as infection by pathogenic bacteria. Considering their strategic localization it is not surprising that DCs have evolved in a series of DC subtypes, which are well adapted to their microenvironment. Nowadays, the advent of the identification of specific DC subtypes has opened the way for the study of pathogen-DCs interactions and the involved mechanisms of these interactions. Due to key aspect of DCs, several bacterial pathogens have taken advantage of these cells and developed mechanisms to subvert DC function and thereby evade the immune system. This review brings recent insights into DC-pathogenic bacteria cross-talk using the mouse model of infection with an emphasis on DC subtypes. CI - Copyright (c) 2015 Elsevier Ltd. All rights reserved. FAU - Papadopoulos, Alexia AU - Papadopoulos A AD - Centre d'Immunologie de Marseille-Luminy, Aix Marseille Universite UM2, Inserm, U1104, CNRS UMR7280, 13288 Marseille, France. FAU - Gorvel, Jean-Pierre AU - Gorvel JP AD - Centre d'Immunologie de Marseille-Luminy, Aix Marseille Universite UM2, Inserm, U1104, CNRS UMR7280, 13288 Marseille, France. Electronic address: gorvel@ciml.univ-mrs.fr. LA - eng PT - Journal Article PT - Review DEP - 20151008 PL - England TA - Microb Pathog JT - Microbial pathogenesis JID - 8606191 SB - IM MH - Animals MH - Bacteria/*immunology MH - Dendritic Cells/*immunology MH - *Host-Pathogen Interactions MH - Immune Evasion MH - Mice OTO - NOTNLM OT - Bacteria OT - Cell activation OT - Dendritic cells OT - Immune response OT - Infection OT - Pathogenesis EDAT- 2015/10/11 06:00 MHDA- 2016/10/07 06:00 CRDT- 2015/10/11 06:00 PHST- 2015/07/22 00:00 [received] PHST- 2015/09/24 00:00 [revised] PHST- 2015/10/04 00:00 [accepted] PHST- 2015/10/11 06:00 [entrez] PHST- 2015/10/11 06:00 [pubmed] PHST- 2016/10/07 06:00 [medline] AID - S0882-4010(15)00164-3 [pii] AID - 10.1016/j.micpath.2015.10.004 [doi] PST - ppublish SO - Microb Pathog. 2015 Dec;89:140-9. doi: 10.1016/j.micpath.2015.10.004. Epub 2015 Oct 8.