PMID- 26454023
OWN - NLM
STAT- MEDLINE
DCOM- 20160913
LR  - 20151128
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Linking)
VI  - 311
DP  - 2015 Dec 17
TI  - Prenatal binge-like alcohol exposure alters brain and systemic responses to reach 
      sodium and water balance.
PG  - 92-104
LID - S0306-4522(15)00911-2 [pii]
LID - 10.1016/j.neuroscience.2015.10.004 [doi]
AB  - The aim of the present work is to analyze how prenatal binge-like ethanol 
      exposure to a moderate dose (2.0 g/kg; group Pre-EtOH) during gestational days 
      (GD) 17-20 affects hydroelectrolyte regulatory responses. This type of exposure 
      has been observed to increase ethanol consumption during adolescence (postnatal 
      day 30-32). In this study we analyzed basal brain neural activity and 
      basal-induced sodium appetite (SA) and renal response stimulated by sodium 
      depletion (SD) as well as voluntary ethanol consumption as a function of vehicle 
      or ethanol during late pregnancy. In adolescent offspring, SD was induced by 
      furosemide and a low-sodium diet treatment (FURO+LSD). Other animals were 
      analyzed in terms of immunohistochemical detection of Fra-like (Fra-LI-ir) 
      protein and serotonin (5HT) and/or vasopressin (AVP). The Pre-EtOH group 
      exhibited heightened voluntary ethanol intake and a reduction in sodium and water 
      intake induced by SD relative to controls. Basal Na and K concentrations in urine 
      were also reduced in Pre-EtOH animals while the induced renal response after FURO 
      treatment was similar across prenatal treatments. However, the correlation 
      between urine volume and water intake induced by FURO significantly varied across 
      these treatments. At the brain level of analysis, the number of basal Fra-LI-ir 
      was significantly increased in AVP magnocellular neurons of the paraventricular 
      nucleus (PVN) and in 5HT neurons in the dorsal raphe nucleus (DRN) in Pre-EtOH 
      pups. In the experimental group, we also observed a significant increase in 
      Fra-LI along the nucleus of the solitary tract (NTS) and in the central extended 
      amygdala nuclei. In summary, moderate Pre-EtOH exposure produces long-lasting 
      changes in brain organization, affecting basal activity of central extended 
      amygdala nuclei, AVP neurons and the inhibitory areas of SA such as the NTS and 
      the 5HT-DRN. These changes possibly modulate the above described variations in 
      basal-induced drinking behaviors and renal regulatory responses.
CI  - Copyright (c) 2015 IBRO. Published by Elsevier Ltd. All rights reserved.
FAU - Godino, A
AU  - Godino A
AD  - Instituto de Investigacion Medica Mercedes y Martin Ferreyra 
      (INIMEC-CONICET-Universidad Nacional de Cordoba), Casilla de Correo 389-5000, 
      Cordoba, Argentina. Electronic address: agodino@immf.uncor.edu.
FAU - Abate, P
AU  - Abate P
AD  - Instituto de Investigacion Medica Mercedes y Martin Ferreyra 
      (INIMEC-CONICET-Universidad Nacional de Cordoba), Casilla de Correo 389-5000, 
      Cordoba, Argentina; Facultad de Psicologia, Universidad Nacional de Cordoba, 
      Cordoba, Argentina.
FAU - Amigone, J L
AU  - Amigone JL
AD  - Seccion de Bioquimica Clinica, Hospital Privado, 16 Cordoba, Argentina.
FAU - Vivas, L
AU  - Vivas L
AD  - Instituto de Investigacion Medica Mercedes y Martin Ferreyra 
      (INIMEC-CONICET-Universidad Nacional de Cordoba), Casilla de Correo 389-5000, 
      Cordoba, Argentina; Facultad de Ciencias Exactas Fisicas y Naturales, Universidad 
      Nacional de Cordoba, Cordoba, Argentina.
FAU - Molina, J C
AU  - Molina JC
AD  - Instituto de Investigacion Medica Mercedes y Martin Ferreyra 
      (INIMEC-CONICET-Universidad Nacional de Cordoba), Casilla de Correo 389-5000, 
      Cordoba, Argentina; Facultad de Psicologia, Universidad Nacional de Cordoba, 
      Cordoba, Argentina.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151008
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Electrolytes)
RN  - 0 (Sodium, Dietary)
SB  - IM
MH  - Animals
MH  - *Binge Drinking
MH  - Brain/*metabolism/pathology
MH  - Disease Models, Animal
MH  - Drinking Behavior/physiology
MH  - Electrolytes/urine
MH  - Female
MH  - Immunohistochemistry
MH  - Male
MH  - Neurons/metabolism/pathology
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Random Allocation
MH  - Rats, Wistar
MH  - Sodium, Dietary
MH  - Water-Electrolyte Balance/*physiology
OTO - NOTNLM
OT  - prenatal ethanol exposure
OT  - serotonergic neurons
OT  - sodium balance
OT  - vasopressinergic neurons
EDAT- 2015/10/11 06:00
MHDA- 2016/09/14 06:00
CRDT- 2015/10/11 06:00
PHST- 2015/05/26 00:00 [received]
PHST- 2015/09/28 00:00 [revised]
PHST- 2015/10/02 00:00 [accepted]
PHST- 2015/10/11 06:00 [entrez]
PHST- 2015/10/11 06:00 [pubmed]
PHST- 2016/09/14 06:00 [medline]
AID - S0306-4522(15)00911-2 [pii]
AID - 10.1016/j.neuroscience.2015.10.004 [doi]
PST - ppublish
SO  - Neuroscience. 2015 Dec 17;311:92-104. doi: 10.1016/j.neuroscience.2015.10.004. 
      Epub 2015 Oct 8.