PMID- 26455459
OWN - NLM
STAT- MEDLINE
DCOM- 20180411
LR  - 20220330
IS  - 1873-5118 (Electronic)
IS  - 0301-0082 (Linking)
VI  - 155
DP  - 2017 Aug
TI  - Amphetamine-related drugs neurotoxicity in humans and in experimental animals: 
      Main mechanisms.
PG  - 149-170
LID - S0301-0082(15)00100-8 [pii]
LID - 10.1016/j.pneurobio.2015.09.011 [doi]
AB  - Amphetamine-related drugs, such as 3,4-methylenedioxymethamphetamine (MDMA) and 
      methamphetamine (METH), are popular recreational psychostimulants. Several 
      preclinical studies have demonstrated that, besides having the potential for 
      abuse, amphetamine-related drugs may also elicit neurotoxic and neuroinflammatory 
      effects. The neurotoxic potentials of MDMA and METH to dopaminergic and 
      serotonergic neurons have been clearly demonstrated in both rodents and non-human 
      primates. This review summarizes the species-specific cellular and molecular 
      mechanisms involved in MDMA and METH-mediated neurotoxic and neuroinflammatory 
      effects, along with the most important behavioral changes elicited by these 
      substances in experimental animals and humans. Emphasis is placed on the 
      neuropsychological and neurological consequences associated with the neuronal 
      damage. Moreover, we point out the gap in our knowledge and the need for 
      developing appropriate therapeutic strategies to manage the neurological problems 
      associated with amphetamine-related drug abuse.
CI  - Copyright (c) 2015 Elsevier Ltd. All rights reserved.
FAU - Moratalla, Rosario
AU  - Moratalla R
AD  - Instituto Cajal, Consejo Superior de Investigaciones Cientificas, CSIC, Madrid, 
      Spain; CIBERNED, ISCIII, Madrid, Spain. Electronic address: 
      moratalla@cajal.csic.es.
FAU - Khairnar, Amit
AU  - Khairnar A
AD  - Applied Neuroscience Research Group, CEITEC - Central European Institute of 
      Technology, Masaryk University, Brno, Czech Republic.
FAU - Simola, Nicola
AU  - Simola N
AD  - Department of Biomedical Sciences, Section of Neuropsychopharmacology, University 
      of Cagliari, Via Ospedale 72, 09124 Cagliari, Italy.
FAU - Granado, Noelia
AU  - Granado N
AD  - Instituto Cajal, Consejo Superior de Investigaciones Cientificas, CSIC, Madrid, 
      Spain; CIBERNED, ISCIII, Madrid, Spain.
FAU - Garcia-Montes, Jose Ruben
AU  - Garcia-Montes JR
AD  - Instituto Cajal, Consejo Superior de Investigaciones Cientificas, CSIC, Madrid, 
      Spain; CIBERNED, ISCIII, Madrid, Spain.
FAU - Porceddu, Pier Francesca
AU  - Porceddu PF
AD  - Department of Biomedical Sciences, Section of Neuropsychopharmacology, University 
      of Cagliari, Via Ospedale 72, 09124 Cagliari, Italy.
FAU - Tizabi, Yousef
AU  - Tizabi Y
AD  - Department of Pharmacology, Howard University College of Medicine, Washington, 
      DC, USA.
FAU - Costa, Giulia
AU  - Costa G
AD  - Department of Biomedical Sciences, Section of Neuropsychopharmacology, University 
      of Cagliari, Via Ospedale 72, 09124 Cagliari, Italy.
FAU - Morelli, Micaela
AU  - Morelli M
AD  - Department of Biomedical Sciences, Section of Neuropsychopharmacology, University 
      of Cagliari, Via Ospedale 72, 09124 Cagliari, Italy; Centre of Excellence for 
      Neurobiology of Dependence, University of Cagliari, Cagliari, Italy; National 
      Research Council (CNR), Institute of Neuroscience, Cagliari, Italy.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20151009
PL  - England
TA  - Prog Neurobiol
JT  - Progress in neurobiology
JID - 0370121
RN  - 44RAL3456C (Methamphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Brain/*drug effects
MH  - Humans
MH  - Methamphetamine/*adverse effects
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*adverse effects
MH  - Neurotoxicity Syndromes/pathology
OTO - NOTNLM
OT  - 3,4-Methylenedioxymethamphetamine
OT  - Dopamine
OT  - Ecstasy
OT  - MDMA
OT  - METH
OT  - Methamphetamine
OT  - Mouse
OT  - Neurodegeneration
OT  - Neuroinflammation neurotoxicity
OT  - Non-human primate
OT  - Rat
EDAT- 2015/10/13 06:00
MHDA- 2018/04/12 06:00
CRDT- 2015/10/13 06:00
PHST- 2015/02/25 00:00 [received]
PHST- 2015/09/04 00:00 [revised]
PHST- 2015/09/15 00:00 [accepted]
PHST- 2015/10/13 06:00 [pubmed]
PHST- 2018/04/12 06:00 [medline]
PHST- 2015/10/13 06:00 [entrez]
AID - S0301-0082(15)00100-8 [pii]
AID - 10.1016/j.pneurobio.2015.09.011 [doi]
PST - ppublish
SO  - Prog Neurobiol. 2017 Aug;155:149-170. doi: 10.1016/j.pneurobio.2015.09.011. Epub 
      2015 Oct 9.