PMID- 26455486
OWN - NLM
STAT- MEDLINE
DCOM- 20180131
LR  - 20220331
IS  - 1995-9133 (Electronic)
IS  - 1684-1182 (Linking)
VI  - 50
IP  - 4
DP  - 2017 Aug
TI  - Time-to-positivity of blood culture: An independent prognostic factor of 
      monomicrobial Pseudomonas aeruginosa bacteremia.
PG  - 486-493
LID - S1684-1182(15)00837-3 [pii]
LID - 10.1016/j.jmii.2015.08.014 [doi]
AB  - BACKGROUND/PURPOSE: Pseudomonas aeruginosa bacteremia is an important cause of 
      nosocomial infections with high morbidity and mortality. Time-to-positivity (TTP) 
      of blood cultures is considered to be a predictor of the clinical outcome for 
      bacteremia. The aim of the study is to investigate the relationship between TTP 
      and clinical outcomes in patients with monomicrobial P. aeruginosa bacteremia. 
      METHODS: From January 2013 to June 2014, a retrospective cohort study was 
      conducted in a 1200-bed tertiary care hospital. The cases of monomicrobial P. 
      aeruginosa bacteremia were studied. TTP and clinical parameters were determined 
      and analyzed. RESULTS: In 139 cases of P. aeruginosa bacteremia, TTP </= 13 hours 
      was associated with higher Pitt bacteremia scores (5.3 +/- 4.2 vs. 2.3 +/- 2.8, 
      p < 0.001), severe sepsis (66.1% vs. 35.0%, p < 0.001), higher 30-day mortality 
      rate (54.2% vs. 15.0%, p < 0.001), longer hospitalization in the survivors 
      (25.6 +/- 48.5 days vs. 16.3 +/- 15.3 days, p = 0.16), and more admission to 
      intensive care unit (27.2% vs. 16.3%, p = 0.14). Risk factors for 30-day 
      mortality in the univariate analysis included corticosteroid exposure, primary 
      bacteremia, concurrent pneumonia, a high Pitt bacteremia score, severe sepsis, 
      and TTP </= 13 hours. In the multivariate analysis, primary bacteremia, a pulmonary 
      origin of bacteremia, severe sepsis, and TTP </= 13 hours were independent risk 
      factors for 30-day mortality. CONCLUSION: In cases of monomicrobial P. aeruginosa 
      bacteremia, a short TTP (</= 13 hours) provides prognostic information, in addition 
      to clinical parameters.
CI  - Copyright (c) 2015. Published by Elsevier B.V.
FAU - Tang, Poh-Chang
AU  - Tang PC
AD  - Division of Infectious Diseases, Department of Internal Medicine, National Cheng 
      Kung University Hospital, Tainan, Taiwan; Division of Infectious Diseases, 
      Department of Internal Medicine, Tainan Municipal Hospital, Tainan, Taiwan.
FAU - Lee, Ching-Chi
AU  - Lee CC
AD  - Division of Infectious Diseases, Department of Internal Medicine, National Cheng 
      Kung University Hospital, Tainan, Taiwan; Center for Infection Control, National 
      Cheng Kung University Hospital, Tainan, Taiwan.
FAU - Li, Chia-Wen
AU  - Li CW
AD  - Division of Infectious Diseases, Department of Internal Medicine, National Cheng 
      Kung University Hospital, Tainan, Taiwan; Center for Infection Control, National 
      Cheng Kung University Hospital, Tainan, Taiwan.
FAU - Li, Ming-Chi
AU  - Li MC
AD  - Division of Infectious Diseases, Department of Internal Medicine, National Cheng 
      Kung University Hospital, Tainan, Taiwan; Center for Infection Control, National 
      Cheng Kung University Hospital, Tainan, Taiwan.
FAU - Ko, Wen-Chien
AU  - Ko WC
AD  - Division of Infectious Diseases, Department of Internal Medicine, National Cheng 
      Kung University Hospital, Tainan, Taiwan; Center for Infection Control, National 
      Cheng Kung University Hospital, Tainan, Taiwan. Electronic address: 
      winston3415@gmail.com.
FAU - Lee, Nan-Yao
AU  - Lee NY
AD  - Division of Infectious Diseases, Department of Internal Medicine, National Cheng 
      Kung University Hospital, Tainan, Taiwan; Center for Infection Control, National 
      Cheng Kung University Hospital, Tainan, Taiwan. Electronic address: 
      nanyao@mail.ncku.edu.tw.
LA  - eng
PT  - Journal Article
DEP - 20150909
PL  - England
TA  - J Microbiol Immunol Infect
JT  - Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi
JID - 100956211
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Bacteremia/*diagnosis/microbiology
MH  - Blood/*microbiology
MH  - Blood Culture/*methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Pseudomonas Infections/*diagnosis/microbiology
MH  - Pseudomonas aeruginosa/*isolation & purification
MH  - Retrospective Studies
MH  - Tertiary Care Centers
MH  - Time Factors
MH  - Young Adult
OTO - NOTNLM
OT  - Pseudomonas aeruginosa
OT  - bacteremia
OT  - time-to-positivity
EDAT- 2015/10/13 06:00
MHDA- 2018/02/01 06:00
CRDT- 2015/10/13 06:00
PHST- 2015/04/30 00:00 [received]
PHST- 2015/08/13 00:00 [revised]
PHST- 2015/08/28 00:00 [accepted]
PHST- 2015/10/13 06:00 [pubmed]
PHST- 2018/02/01 06:00 [medline]
PHST- 2015/10/13 06:00 [entrez]
AID - S1684-1182(15)00837-3 [pii]
AID - 10.1016/j.jmii.2015.08.014 [doi]
PST - ppublish
SO  - J Microbiol Immunol Infect. 2017 Aug;50(4):486-493. doi: 
      10.1016/j.jmii.2015.08.014. Epub 2015 Sep 9.