PMID- 26455726
OWN - NLM
STAT- MEDLINE
DCOM- 20160520
LR  - 20240324
IS  - 2041-1723 (Electronic)
IS  - 2041-1723 (Linking)
VI  - 6
DP  - 2015 Oct 12
TI  - A biosynthetic model of cytochrome c oxidase as an electrocatalyst for oxygen 
      reduction.
PG  - 8467
LID - 10.1038/ncomms9467 [doi]
LID - 8467
AB  - Creating an artificial functional mimic of the mitochondrial enzyme cytochrome c 
      oxidase (CcO) has been a long-term goal of the scientific community as such a 
      mimic will not only add to our fundamental understanding of how CcO works but may 
      also pave the way for efficient electrocatalysts for oxygen reduction in 
      hydrogen/oxygen fuel cells. Here we develop an electrocatalyst for reducing 
      oxygen to water under ambient conditions. We use site-directed mutants of 
      myoglobin, where both the distal Cu and the redox-active tyrosine residue present 
      in CcO are modelled. In situ Raman spectroscopy shows that this catalyst features 
      very fast electron transfer rates, facile oxygen binding and O-O bond lysis. An 
      electron transfer shunt from the electrode circumvents the slow dissociation of a 
      ferric hydroxide species, which slows down native CcO (bovine 500 s(-1)), 
      allowing electrocatalytic oxygen reduction rates of 5,000 s(-1) for these 
      biosynthetic models.
FAU - Mukherjee, Sohini
AU  - Mukherjee S
AD  - Department of Inorganic Chemistry, Indian Association for the Cultivation of 
      Science, 2A&2B Raja SC Mullick Road, Jadavpur Kolkata 700032, India.
FAU - Mukherjee, Arnab
AU  - Mukherjee A
AD  - Department of Chemistry, University of Illinois at Urbana-Champaign, Champaign, 
      Illinois 61801, USA.
FAU - Bhagi-Damodaran, Ambika
AU  - Bhagi-Damodaran A
AD  - Department of Chemistry, University of Illinois at Urbana-Champaign, Champaign, 
      Illinois 61801, USA.
FAU - Mukherjee, Manjistha
AU  - Mukherjee M
AD  - Department of Inorganic Chemistry, Indian Association for the Cultivation of 
      Science, 2A&2B Raja SC Mullick Road, Jadavpur Kolkata 700032, India.
FAU - Lu, Yi
AU  - Lu Y
AD  - Department of Chemistry, University of Illinois at Urbana-Champaign, Champaign, 
      Illinois 61801, USA.
FAU - Dey, Abhishek
AU  - Dey A
AUID- ORCID: 0000-0002-9166-3349
AD  - Department of Inorganic Chemistry, Indian Association for the Cultivation of 
      Science, 2A&2B Raja SC Mullick Road, Jadavpur Kolkata 700032, India.
LA  - eng
GR  - R01 GM062211/GM/NIGMS NIH HHS/United States
GR  - GM062211/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20151012
PL  - England
TA  - Nat Commun
JT  - Nature communications
JID - 101528555
RN  - 7440-57-5 (Gold)
RN  - EC 1.9.3.1 (Electron Transport Complex IV)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Catalysis
MH  - Electrodes
MH  - Electron Transport Complex IV/*chemistry
MH  - Gold
MH  - Oxidation-Reduction
MH  - Oxygen/*chemistry
MH  - Photoelectron Spectroscopy
MH  - Spectrum Analysis, Raman
PMC - PMC4633646
EDAT- 2015/10/13 06:00
MHDA- 2016/05/21 06:00
PMCR- 2015/11/05
CRDT- 2015/10/13 06:00
PHST- 2014/12/15 00:00 [received]
PHST- 2015/08/24 00:00 [accepted]
PHST- 2015/10/13 06:00 [entrez]
PHST- 2015/10/13 06:00 [pubmed]
PHST- 2016/05/21 06:00 [medline]
PHST- 2015/11/05 00:00 [pmc-release]
AID - ncomms9467 [pii]
AID - 10.1038/ncomms9467 [doi]
PST - epublish
SO  - Nat Commun. 2015 Oct 12;6:8467. doi: 10.1038/ncomms9467.