PMID- 26456009
OWN - NLM
STAT- MEDLINE
DCOM- 20160418
LR  - 20220409
IS  - 1096-9896 (Electronic)
IS  - 0022-3417 (Linking)
VI  - 238
IP  - 2
DP  - 2016 Jan
TI  - Model systems of human papillomavirus-associated disease.
PG  - 166-79
LID - 10.1002/path.4656 [doi]
AB  - Human papillomaviruses (HPVs) cause a range of serious diseases, including the 
      vast majority of cervical cancers, most anal cancers and around half of head and 
      neck cancers. They are also responsible for troublesome benign epithelial 
      lesions, including genital warts and laryngeal papillomas, and in some 
      individuals HPVs lead to recurrent respiratory papillomatosis and other 
      difficult-to-manage diseases. As a result, there is a great need for model 
      systems that accurately mimic papillomavirus infections in humans. This is 
      complicated by the diverse variety of HPVs, which now number over 200 types, and 
      the different strategies they have evolved to persist in the population. The most 
      well-developed models involve the culture of HPV-containing keratinocytes in 
      organotypic raft culture, an approach which appears to accurately mimic the life 
      cycle of several of the high-risk cancer-associated HPV types. Included amongst 
      these are HPV16 and 18, which cause the majority of cervical cancers. The 
      low-risk HPV types persist less well in tissue-culture models, and our ability to 
      study the productive life cycle of these viruses is more limited. Although 
      ongoing research is likely to improve this situation, animal models of 
      papillomavirus disease can provide considerable basic information as to how 
      lesions form, regress and can be controlled by the immune system. The best 
      studied are cottontail rabbit papillomavirus, rabbit oral papillomavirus and, 
      more recently, mouse papillomavirus (MmuPV), the last of which is providing 
      exciting new insights into viral tropisms and immune control. In addition, 
      transgenic models of disease have helped us to understand the consequences of 
      persistent viral gene expression and the importance of co-factors such as 
      hormones and UV irradiation in the development of neoplasia and cancer. It is 
      hoped that such disease models will eventually lead us to better understanding 
      and better treatments for human disease.
CI  - Copyright (c) 2015 Pathological Society of Great Britain and Ireland. Published by 
      John Wiley & Sons, Ltd.
FAU - Doorbar, John
AU  - Doorbar J
AD  - Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, 
      UK.
LA  - eng
GR  - MC_PC_13050/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20151210
PL  - England
TA  - J Pathol
JT  - The Journal of pathology
JID - 0204634
RN  - 0 (Papillomavirus Vaccines)
SB  - IM
MH  - Animals
MH  - Animals, Genetically Modified
MH  - Carcinogenesis
MH  - Cell Culture Techniques
MH  - *Disease Models, Animal
MH  - Disease Progression
MH  - Forecasting
MH  - Humans
MH  - In Vitro Techniques
MH  - Mice
MH  - Neoplasms/*virology
MH  - *Papillomaviridae
MH  - Papillomavirus Infections/*complications/prevention & control
MH  - Papillomavirus Vaccines
MH  - Rabbits
MH  - Risk Factors
MH  - Tumor Virus Infections/prevention & control/virology
OTO - NOTNLM
OT  - HPV
OT  - animal models
OT  - epithelium
OT  - organotypic rafts
OT  - papillomaviruses
EDAT- 2015/10/13 06:00
MHDA- 2016/04/19 06:00
CRDT- 2015/10/13 06:00
PHST- 2015/09/30 00:00 [received]
PHST- 2015/09/30 00:00 [revised]
PHST- 2015/10/07 00:00 [accepted]
PHST- 2015/10/13 06:00 [entrez]
PHST- 2015/10/13 06:00 [pubmed]
PHST- 2016/04/19 06:00 [medline]
AID - 10.1002/path.4656 [doi]
PST - ppublish
SO  - J Pathol. 2016 Jan;238(2):166-79. doi: 10.1002/path.4656. Epub 2015 Dec 10.