PMID- 26456932 OWN - NLM STAT- MEDLINE DCOM- 20180911 LR - 20181201 IS - 1751-7893 (Electronic) IS - 1751-7885 (Print) IS - 1751-7885 (Linking) VI - 11 IP - 6 DP - 2017 Dec TI - Anxiety in youth at clinical high risk for psychosis. PG - 480-487 LID - 10.1111/eip.12274 [doi] AB - AIM: High rates of anxiety have been observed in youth at clinical high risk (CHR) of developing psychosis. In CHR, anxiety often co-occurs with depression, and there is inconsistent evidence on anxiety in relation to transition to psychosis. The aim of this study was to examine: (i) the prevalence of anxiety disorders in individuals at CHR; (ii) clinical differences between those with and without anxiety; and (iii) the association of baseline anxiety with later transition to psychosis. METHODS: The sample consisted of 765 CHR individuals and 280 healthy controls. CHR status was determined with the Structured Interview of Prodromal Syndromes, mood and anxiety diagnoses with the Structured Clinical Interview for DSM-IV Disorders, and severity of anxiety with the Social Interaction Anxiety Scale and Self-Rating Anxiety Scale. RESULTS: In the CHR sample, 51% met criteria for an anxiety disorder. CHR participants had significantly more anxiety diagnoses and severity than healthy controls. Anxiety was correlated to attenuated psychotic and negative symptoms in CHR and those with an anxiety disorder demonstrated more suspiciousness. CHR participants with obsessive-compulsive disorder (OCD) exhibited more severe symptomatology than those without OCD. An initial presentation of anxiety did not differ between those who did or did not transition to psychosis. CONCLUSIONS: In this large sample of individuals at CHR, anxiety is common and associated with more severe attenuated psychotic symptoms. Treatment not only to prevent or delay transition to psychosis but also to address presenting concerns, such as anxiety, is warranted. CI - (c) 2015 Wiley Publishing Asia Pty Ltd. FAU - McAusland, Laina AU - McAusland L AD - Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada. FAU - Buchy, Lisa AU - Buchy L AD - Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada. FAU - Cadenhead, Kristin S AU - Cadenhead KS AD - Department of Psychiatry, UC San Diego, La Jolla, California, USA. FAU - Cannon, Tyrone D AU - Cannon TD AD - Department of Psychology, Yale University, New Haven, Connecticut, USA. FAU - Cornblatt, Barbara A AU - Cornblatt BA AD - Department of Psychiatry, Zucker Hillside Hospital, Long Island, New York, USA. FAU - Heinssen, Robert AU - Heinssen R AD - Division of Services and Intervention Research, National Institute of Mental Health, Bethesda, Maryland, USA. FAU - McGlashan, Thomas H AU - McGlashan TH AD - Department of Psychiatry, Yale University, New Haven, Connecticut, USA. FAU - Perkins, Diana O AU - Perkins DO AD - Department of Psychiatry, University of North Carolina, Chapel Hill, North Carolina, USA. FAU - Seidman, Larry J AU - Seidman LJ AD - Department of Psychiatry, Harvard Medical School at Beth Israel Deaconess Medical Center and Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Tsuang, Ming T AU - Tsuang MT AD - Department of Psychiatry, UC San Diego, La Jolla, California, USA. FAU - Walker, Elaine F AU - Walker EF AD - Departments of Psychology and Psychiatry, Emory University, Atlanta, Georgia, USA. FAU - Woods, Scott W AU - Woods SW AD - Department of Psychiatry, Yale University, New Haven, Connecticut, USA. FAU - Bearden, Carrie E AU - Bearden CE AD - Departments of Psychiatry and Biobehavioral Sciences and Psychology, UCLA, Los Angeles, California, USA. FAU - Mathalon, Daniel H AU - Mathalon DH AD - Department of Psychiatry, UCSF, SFVA Medical Center, San Francisco, California, USA. FAU - Addington, Jean AU - Addington J AD - Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada. LA - eng GR - U01 MH082022/MH/NIMH NIH HHS/United States GR - U01 MH081984/MH/NIMH NIH HHS/United States GR - UL1 TR001863/TR/NCATS NIH HHS/United States GR - U01 MH081902/MH/NIMH NIH HHS/United States GR - P50 MH080272/MH/NIMH NIH HHS/United States GR - U01 MH081988/MH/NIMH NIH HHS/United States GR - P50 MH066286/MH/NIMH NIH HHS/United States GR - U01 MH076989/MH/NIMH NIH HHS/United States GR - K24 MH076191/MH/NIMH NIH HHS/United States GR - R01 MH060720/MH/NIMH NIH HHS/United States GR - U01 MH081928/MH/NIMH NIH HHS/United States GR - U01 MH081857/MH/NIMH NIH HHS/United States GR - U01 MH082004/MH/NIMH NIH HHS/United States GR - U01 MH081944/MH/NIMH NIH HHS/United States PT - Journal Article PT - Multicenter Study DEP - 20151012 PL - Australia TA - Early Interv Psychiatry JT - Early intervention in psychiatry JID - 101320027 SB - IM MH - Adolescent MH - Anxiety Disorders/*epidemiology MH - Case-Control Studies MH - Comorbidity MH - Female MH - Humans MH - Male MH - Prodromal Symptoms MH - Psychotic Disorders/diagnosis/*epidemiology MH - United States/epidemiology MH - Young Adult PMC - PMC4912451 MID - NIHMS717415 OTO - NOTNLM OT - anxiety OT - clinical high risk OT - obsessive-compulsive disorder OT - social phobia OT - suspiciousness EDAT- 2015/10/13 06:00 MHDA- 2018/09/12 06:00 PMCR- 2018/12/01 CRDT- 2015/10/13 06:00 PHST- 2015/02/23 00:00 [received] PHST- 2015/08/17 00:00 [accepted] PHST- 2015/10/13 06:00 [pubmed] PHST- 2018/09/12 06:00 [medline] PHST- 2015/10/13 06:00 [entrez] PHST- 2018/12/01 00:00 [pmc-release] AID - 10.1111/eip.12274 [doi] PST - ppublish SO - Early Interv Psychiatry. 2017 Dec;11(6):480-487. doi: 10.1111/eip.12274. Epub 2015 Oct 12.