PMID- 26457539
OWN - NLM
STAT- MEDLINE
DCOM- 20160105
LR  - 20220316
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 56
IP  - 11
DP  - 2015 Oct
TI  - Choroidal Thickness Evaluation Before and After Hemodialysis in Patients With and 
      Without Diabetes.
PG  - 6534-41
LID - 10.1167/iovs.15-16719 [doi]
AB  - PURPOSE: We evaluated the effect of hemodialysis on the choroidal thickness in 
      patients with and without diabetes who have end-stage kidney disease (ESKD). 
      METHODS: Forty-one patients with ESKD were recruited and divided into two groups: 
      those with ESKD due to diabetic nephropathy (DM group, 37 eyes of 20 patients) 
      and those with nondiabetic ESKD (NDM group, 40 eyes of 21 patients). Using 
      spectral-domain optical coherence tomography (SD-OCT), the subfoveal choroidal 
      thickness (SCT) was measured before and after hemodialysis, and the change ratio 
      (DeltaSCT [%]) was calculated. RESULTS: The SCT decreased in all eyes after 
      hemodialysis. The DeltaSCT value in the DM group (-12.6 +/- 2.7%) was significantly (P 
      = 0.00027) larger than that in the NDM group (-6.9 +/- 2.3%). Moreover, the DeltaSCT 
      per body fluid removal (BFR [L]) in the DM group was significantly (P = 0.013) 
      greater than in the NDM group. In the DM group, the mean DeltaSCT in the eyes treated 
      with panretinal photocoagulation (PRP; n = 19) was significantly (P = 0.035) 
      larger than that in eyes not treated with PRP (n = 18). The relationship between 
      the DeltaSCT and BFR was not significant (R(2) = 0.0038, P = 0.80) in the DM group but 
      was significant (R(2) = 0.54, P = 0.00013) in the NDM group. CONCLUSIONS: The 
      current results may reflect that systemic fluid accumulation has a greater effect 
      on the diabetic choroid, probably due to damage to the choroidal vasculature, in 
      patients with ESKD.
FAU - Ishibazawa, Akihiro
AU  - Ishibazawa A
AD  - Department of Ophthalmology Asahikawa Medical University, Asahikawa, Japan 
      2Department of Ophthalmology, Nayoro City General Hospital, Nayoro, Japan.
FAU - Nagaoka, Taiji
AU  - Nagaoka T
AD  - Department of Ophthalmology Asahikawa Medical University, Asahikawa, Japan.
FAU - Minami, Yoshiro
AU  - Minami Y
AD  - Department of Ophthalmology, Nayoro City General Hospital, Nayoro, Japan.
FAU - Kitahara, Manabu
AU  - Kitahara M
AD  - Department of Urology, Nayoro City General Hospital, Nayoro, Japan.
FAU - Yamashita, Takanori
AU  - Yamashita T
AD  - Department of Urology, Nayoro City General Hospital, Nayoro, Japan.
FAU - Yoshida, Akitoshi
AU  - Yoshida A
AD  - Department of Ophthalmology Asahikawa Medical University, Asahikawa, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Aged
MH  - Choroid/*pathology
MH  - Choroid Diseases/*diagnosis/etiology
MH  - Diabetic Nephropathies/complications/*therapy
MH  - Female
MH  - Fluorescein Angiography
MH  - Fundus Oculi
MH  - Humans
MH  - Kidney Failure, Chronic/complications/therapy
MH  - Male
MH  - *Renal Dialysis
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence/*methods
MH  - Visual Acuity
EDAT- 2015/10/13 06:00
MHDA- 2016/01/06 06:00
CRDT- 2015/10/13 06:00
PHST- 2015/10/13 06:00 [entrez]
PHST- 2015/10/13 06:00 [pubmed]
PHST- 2016/01/06 06:00 [medline]
AID - 2461803 [pii]
AID - 10.1167/iovs.15-16719 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2015 Oct;56(11):6534-41. doi: 10.1167/iovs.15-16719.