PMID- 26458424
OWN - NLM
STAT- MEDLINE
DCOM- 20160218
LR  - 20151013
IS  - 0485-1439 (Print)
IS  - 0485-1439 (Linking)
VI  - 56
IP  - 10
DP  - 2015 Oct
TI  - [Recent progress in leukemic stem cell research for childhood leukemia].
PG  - 1871-81
LID - 10.11406/rinketsu.56.1871 [doi]
AB  - Leukemic stem cells (LSCs) were originally identified in acute myeloid leukemia 
      (AML) cases by using xenograft models, as a distinct cell population that can 
      initiate leukemia in immunodeficient mice. Since then, many efforts have been 
      made to clarify the identities of LSCs and other cancer stem cells in various 
      cancer types, to both understand their biology and determine the most suitable 
      targets for anti-cancer therapies. LSCs were identified as existing in the 
      immature CD34+CD38- leukemic population in most AML cases, and these cells were 
      found to share some features with normal hematopoietic stem cells. On the other 
      hand, recent studies have shown that in childhood acute lymphoblastic leukemia 
      (ALL), LSCs exist among B-lineage-committed progenitors expressing CD19. In 
      contrast to AML, in which LSCs generate leukemic cells in a hierarchical order 
      with LSCs at the top, leukemia propagation in childhood ALL is better explained 
      by a stochastic model. In B-precursor ALL, LSCs form via acquisition of 
      additional genetic change(s) in CD19+ B-lineage progenitor cells with 
      self-renewing capacity. These LSCs possess a growth advantage and the capacity to 
      produce progeny with the same ability as the LSCs. Identification of genetic and 
      cellular targets in leukemic transformation is necessary to develop improved 
      anti-cancer therapies.
FAU - Eguchi, Mariko
AU  - Eguchi M
AD  - Department of Pediatrics, Ehime University Graduate School of Medicine.
FAU - Eguchi-Ishimae, Minenori
AU  - Eguchi-Ishimae M
FAU - Ishii, Eiichi
AU  - Ishii E
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Rinsho Ketsueki
JT  - [Rinsho ketsueki] The Japanese journal of clinical hematology
JID - 2984782R
SB  - IM
MH  - Age of Onset
MH  - Animals
MH  - Cell Transformation, Neoplastic
MH  - Child
MH  - Humans
MH  - *Leukemia/genetics/metabolism
MH  - *Neoplastic Stem Cells/metabolism
MH  - Stem Cell Research
EDAT- 2015/10/16 06:00
MHDA- 2016/02/19 06:00
CRDT- 2015/10/14 06:00
PHST- 2015/10/14 06:00 [entrez]
PHST- 2015/10/16 06:00 [pubmed]
PHST- 2016/02/19 06:00 [medline]
AID - 10.11406/rinketsu.56.1871 [doi]
PST - ppublish
SO  - Rinsho Ketsueki. 2015 Oct;56(10):1871-81. doi: 10.11406/rinketsu.56.1871.