PMID- 26458453
OWN - NLM
STAT- MEDLINE
DCOM- 20160218
LR  - 20151013
IS  - 0485-1439 (Print)
IS  - 0485-1439 (Linking)
VI  - 56
IP  - 10
DP  - 2015 Oct
TI  - [Basic understanding of the HLA system in allogeneic hematopoietic cell 
      transplantation].
PG  - 2134-43
LID - 10.11406/rinketsu.56.2134 [doi]
AB  - Human immune responses are principally characterized by the human leukocyte 
      antigen (HLA) system, a diverse set of cell surface molecules encoded by the 
      major histocompatibility complex gene cluster on the short arm of chromosome 6. 
      Among various members of the HLA family, the best characterized are the classic 
      highly polymorphic class I and class II molecules that are responsible for 
      antigen presentation to T cells and regulation of NK cell functions. In 
      allogeneic hematopoietic cell transplantation, sophisticated approaches to 
      donor-recipient allele-level matching at 3 class I (HLA-A/B/C) and 3 class II 
      (HLA-DRB1/DQB1/DPB1) loci have been proven to lower the risk of immunologic 
      complications such as graft failure and graft-versus-host disease, and possibly 
      to confer effective graft-versus-malignancy effects. Future areas of research 
      include clarifying the role of relatively non-polymorphic non-classical HLA 
      molecules (HLA-E/F/G, HLA-DM/DO) and polymorphic/non-polymorphic class I-related 
      molecules (MICA, MICB, HFE, MR1, CD1, FcRn) in the immune regulation that follows 
      hematopoietic cell transplantation.
FAU - Ichinohe, Tatsuo
AU  - Ichinohe T
AD  - Department of Hematology and Oncology, Hiroshima University Hospital.
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Rinsho Ketsueki
JT  - [Rinsho ketsueki] The Japanese journal of clinical hematology
JID - 2984782R
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Genetic Loci
MH  - HLA Antigens/chemistry/genetics/*immunology
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Humans
MH  - Transplantation, Homologous
EDAT- 2015/10/16 06:00
MHDA- 2016/02/19 06:00
CRDT- 2015/10/14 06:00
PHST- 2015/10/14 06:00 [entrez]
PHST- 2015/10/16 06:00 [pubmed]
PHST- 2016/02/19 06:00 [medline]
AID - 10.11406/rinketsu.56.2134 [doi]
PST - ppublish
SO  - Rinsho Ketsueki. 2015 Oct;56(10):2134-43. doi: 10.11406/rinketsu.56.2134.