PMID- 26460781
OWN - NLM
STAT- MEDLINE
DCOM- 20161019
LR  - 20220317
IS  - 1873-3360 (Electronic)
IS  - 0306-4530 (Linking)
VI  - 63
DP  - 2016 Jan
TI  - Determinants of brain-derived neurotrophic factor (BDNF) in umbilical cord and 
      maternal serum.
PG  - 191-7
LID - S0306-4530(15)00931-2 [pii]
LID - 10.1016/j.psyneuen.2015.09.028 [doi]
AB  - OBJECTIVE: Brain-derived neurotrophic factor (BDNF) plays a fundamental role in 
      brain development; additionally, it is involved in various aspects of cerebral 
      function, including neurodegenerative and psychiatric diseases. Involvement of 
      BDNF in parturition has not been investigated. The aim of our study was to 
      analyze determinants of umbilical cord BDNF (UC-BDNF) concentrations of healthy, 
      term newborns and their respective mothers. METHODS: This cross-sectional 
      prospective study was performed at a tertiary referral center. Maternal venous 
      blood samples were taken on admission to labor ward; newborn venous blood samples 
      were drawn from the umbilical cord (UC), before delivery of the placenta. 
      Analysis was performed with a commercially available immunoassay. Univariate 
      analyses and stepwise multivariate regression models were applied. RESULTS: 120 
      patients were recruited. UC-BDNF levels were lower than maternal serum 
      concentrations (median 641 ng/mL, IQR 506 vs. median 780 ng/mL, IQR 602). 
      Correlation between UC- and maternal BDNF was low (R=0.251, p=0.01). In 
      univariate analysis, mode of delivery (MoD), gestational age (GA), body mass 
      index at delivery, and gestational diabetes were determinants of UC-BDNF (MoD and 
      smoking for maternal BDNF, respectively). Stepwise multivariate regression 
      analysis revealed a model with MoD and GA as determinants for UC-BDNF (MoD for 
      maternal BDNF). CONCLUSIONS: MoD and GA at delivery are determinants of 
      circulating BDNF in the mother and newborn. We hypothesize that BDNF, like other 
      neuroendocrine factors, is involved in the neuroendocrine cascade of delivery. 
      Timing and mode of delivery may exert BDNF-induced effects on the cerebral 
      function of newborns and their mothers.
CI  - Copyright (c) 2015 Elsevier Ltd. All rights reserved.
FAU - Flock, A
AU  - Flock A
AD  - Department of Obstetrics and Prenatal Medicine, University Bonn Medical School, 
      Germany.
FAU - Weber, S K
AU  - Weber SK
AD  - Department of Obstetrics and Prenatal Medicine, University Bonn Medical School, 
      Germany.
FAU - Ferrari, N
AU  - Ferrari N
AD  - Department for Physical Activity in Public Health, Institute of Movement and 
      Neurosciences, German Sport University, Cologne, Germany.
FAU - Fietz, C
AU  - Fietz C
AD  - Department for Physical Activity in Public Health, Institute of Movement and 
      Neurosciences, German Sport University, Cologne, Germany.
FAU - Graf, C
AU  - Graf C
AD  - Department for Physical Activity in Public Health, Institute of Movement and 
      Neurosciences, German Sport University, Cologne, Germany.
FAU - Fimmers, R
AU  - Fimmers R
AD  - Institute for Medical Biometry, Informatics and Epidemiology, University Bonn 
      Medical School, Germany.
FAU - Gembruch, U
AU  - Gembruch U
AD  - Department of Obstetrics and Prenatal Medicine, University Bonn Medical School, 
      Germany.
FAU - Merz, W M
AU  - Merz WM
AD  - Department of Obstetrics and Prenatal Medicine, University Bonn Medical School, 
      Germany. Electronic address: waltraut.merz@ukb.uni-bonn.de.
LA  - eng
PT  - Journal Article
DEP - 20151020
PL  - England
TA  - Psychoneuroendocrinology
JT  - Psychoneuroendocrinology
JID - 7612148
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Cross-Sectional Studies
MH  - Delivery, Obstetric/methods
MH  - Female
MH  - Fetal Blood/*metabolism
MH  - Gestational Age
MH  - Humans
MH  - Infant, Newborn
MH  - Male
MH  - Mothers
MH  - Pregnancy/*blood
MH  - Umbilical Cord/metabolism
OTO - NOTNLM
OT  - BDNF
OT  - Delivery
OT  - Neurotrophin
OT  - Newborn
OT  - Pregnancy
OT  - Umbilical cord
EDAT- 2015/10/16 06:00
MHDA- 2016/12/30 06:00
CRDT- 2015/10/14 06:00
PHST- 2015/07/11 00:00 [received]
PHST- 2015/09/07 00:00 [revised]
PHST- 2015/09/28 00:00 [accepted]
PHST- 2015/10/14 06:00 [entrez]
PHST- 2015/10/16 06:00 [pubmed]
PHST- 2016/12/30 06:00 [medline]
AID - S0306-4530(15)00931-2 [pii]
AID - 10.1016/j.psyneuen.2015.09.028 [doi]
PST - ppublish
SO  - Psychoneuroendocrinology. 2016 Jan;63:191-7. doi: 10.1016/j.psyneuen.2015.09.028. 
      Epub 2015 Oct 20.