PMID- 26462158
OWN - NLM
STAT- MEDLINE
DCOM- 20160926
LR  - 20181113
IS  - 1949-2553 (Electronic)
IS  - 1949-2553 (Linking)
VI  - 6
IP  - 39
DP  - 2015 Dec 8
TI  - Decoding Warburg's hypothesis: tumor-related mutations in the mitochondrial 
      respiratory chain.
PG  - 41582-99
LID - 10.18632/oncotarget.6057 [doi]
AB  - Otto Warburg observed that cancer cells derived their energy from aerobic 
      glycolysis by converting glucose to lactate. This mechanism is in opposition to 
      the higher energy requirements of cancer cells because oxidative phosphorylation 
      (OxPhos) produces more ATP from glucose. Warburg hypothesized that this 
      phenomenon occurs due to the malfunction of mitochondria in cancer cells. The 
      rediscovery of Warburg's hypothesis coincided with the discovery of mitochondrial 
      tumor suppressor genes that may conform to Warburg's hypothesis along with the 
      demonstrated negative impact of HIF-1 on PDH activity and the activation of HIF-1 
      by oncogenic signals such as activated AKT. This work summarizes the alterations 
      in mitochondrial respiratory chain proteins that have been identified and their 
      involvement in cancer. Also discussed is the fact that most of the mitochondrial 
      mutations have been found in homoplasmy, indicating a positive selection during 
      tumor evolution, thereby supporting their causal role.
FAU - Garcia-Heredia, Jose M
AU  - Garcia-Heredia JM
AD  - Instituto de Biomedicina de Sevilla (IBIS), HUVR/CSIC/Universidad de Sevilla, 
      Sevilla, Spain.
AD  - Departamento de Bioquimica Vegetal y Biologia Molecular, Facultad de Biologia, 
      Sevilla, Spain.
FAU - Carnero, Amancio
AU  - Carnero A
AD  - Instituto de Biomedicina de Sevilla (IBIS), HUVR/CSIC/Universidad de Sevilla, 
      Sevilla, Spain.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Oncotarget
JT  - Oncotarget
JID - 101532965
RN  - 0 (Electron Transport Chain Complex Proteins)
RN  - 0 (Mitochondrial Proteins)
SB  - IM
MH  - Animals
MH  - Cell Transformation, Neoplastic/*genetics/metabolism/pathology
MH  - Electron Transport Chain Complex Proteins/*genetics/metabolism
MH  - Energy Metabolism/*genetics
MH  - Genetic Predisposition to Disease
MH  - Glycolysis/genetics
MH  - Humans
MH  - Mitochondria/*metabolism/pathology
MH  - Mitochondrial Proteins/*genetics/metabolism
MH  - *Mutation
MH  - Neoplasms/*genetics/metabolism/pathology
MH  - Oxidative Phosphorylation
MH  - Phenotype
MH  - Risk Factors
PMC - PMC4747175
OTO - NOTNLM
OT  - Warburg's hypothesis
OT  - cancer
OT  - metabolic switch
OT  - mitochondrial respiration
OT  - mitochondrial respiratory chain
COIS- CONFLICTS OF INTERESTS The authors declare no conflicts of interest
EDAT- 2015/10/16 06:00
MHDA- 2016/09/27 06:00
PMCR- 2015/12/08
CRDT- 2015/10/14 06:00
PHST- 2015/07/06 00:00 [received]
PHST- 2015/09/23 00:00 [accepted]
PHST- 2015/10/14 06:00 [entrez]
PHST- 2015/10/16 06:00 [pubmed]
PHST- 2016/09/27 06:00 [medline]
PHST- 2015/12/08 00:00 [pmc-release]
AID - 6057 [pii]
AID - 10.18632/oncotarget.6057 [doi]
PST - ppublish
SO  - Oncotarget. 2015 Dec 8;6(39):41582-99. doi: 10.18632/oncotarget.6057.