PMID- 26462261
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151014
LR  - 20181113
IS  - 2054-4774 (Print)
IS  - 2054-4774 (Electronic)
IS  - 2054-4774 (Linking)
VI  - 1
IP  - 1
DP  - 2014
TI  - Does long-term use of proton pump inhibitors cause hypomagnesaemia in Japanese 
      outpatients?
PG  - e000003
LID - 10.1136/bmjgast-2014-000003 [doi]
LID - e000003
AB  - AIM: Hypomagnesaemia has been reported associated with long-term proton pump 
      inhibitor (PPI) treatment. However, there have been no studies in Japanese 
      patients. We therefore assessed the effects of long-term PPI use on serum 
      magnesium concentrations in Japanese patients. METHODS: Data from 481 outpatients 
      who visited our centre in October and November 2011 were reviewed to determine 
      their underlying diseases, oral medications, including PPIs, and serum magnesium 
      concentrations. The association between PPI use and serum Mg concentrations was 
      assessed by multiple linear regression analysis. RESULTS: Serum magnesium 
      concentrations were significantly lower in PPI users (n=199) than in PPI 
      non-users (n=282; 1.86+/-0.21 vs 1.91+/-0.19 mg/dL, p<0.01). Multiple linear 
      regression analysis showed that the presence or absence of cirrhosis and PPI use 
      was a significant predictor of magnesium concentration. In evaluating magnesium 
      concentrations among PPI users and non-users with and without cirrhosis, we found 
      that mean serum magnesium concentrations in patients with cirrhosis were 
      significantly lower in PPI users than non-users (1.78+/-0.22 vs 1.87+/-0.22 mg/dL, 
      p=0.03). CONCLUSIONS: Outpatients receiving long-term PPI treatment had 
      significantly lower serum magnesium concentrations than those not treated with 
      PPI. To the best of our knowledge, this study is the first to show 
      hypomagnesaemia in Japanese patients with cirrhosis receiving long-term PPI 
      treatment.
FAU - Takeda, Yasuhito
AU  - Takeda Y
AD  - Department of Gastroenterology , Ishikawa Prefectural Central Hospital , Ishikawa 
      , Japan.
FAU - Doyama, Hisashi
AU  - Doyama H
AD  - Department of Gastroenterology , Ishikawa Prefectural Central Hospital , Ishikawa 
      , Japan.
FAU - Tsuji, Kunihiro
AU  - Tsuji K
AD  - Department of Gastroenterology , Ishikawa Prefectural Central Hospital , Ishikawa 
      , Japan.
FAU - Yamada, Shinya
AU  - Yamada S
AD  - Department of Gastroenterology , Ishikawa Prefectural Central Hospital , Ishikawa 
      , Japan.
FAU - Takemura, Kenichi
AU  - Takemura K
AD  - Department of Gastroenterology , Ishikawa Prefectural Central Hospital , Ishikawa 
      , Japan.
LA  - eng
PT  - Journal Article
DEP - 20150206
PL  - England
TA  - BMJ Open Gastroenterol
JT  - BMJ open gastroenterology
JID - 101660690
PMC - PMC4533322
OTO - NOTNLM
OT  - LIVER CIRRHOSIS
OT  - PROTON PUMP INHIBITION
OT  - SMALL INTESTINE
EDAT- 2014/01/01 00:00
MHDA- 2014/01/01 00:01
PMCR- 2015/02/06
CRDT- 2015/10/14 06:00
PHST- 2014/04/14 00:00 [received]
PHST- 2014/09/10 00:00 [revised]
PHST- 2014/09/19 00:00 [accepted]
PHST- 2015/10/14 06:00 [entrez]
PHST- 2014/01/01 00:00 [pubmed]
PHST- 2014/01/01 00:01 [medline]
PHST- 2015/02/06 00:00 [pmc-release]
AID - bmjgast-2014-000003 [pii]
AID - 10.1136/bmjgast-2014-000003 [doi]
PST - epublish
SO  - BMJ Open Gastroenterol. 2015 Feb 6;1(1):e000003. doi: 
      10.1136/bmjgast-2014-000003. eCollection 2014.