PMID- 26462556
OWN - NLM
STAT- MEDLINE
DCOM- 20160815
LR  - 20220317
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 5
DP  - 2015 Oct 14
TI  - Quantitative assessment of common genetic variations in HLA-DP with hepatitis B 
      virus infection, clearance and hepatocellular carcinoma development.
PG  - 14933
LID - 10.1038/srep14933 [doi]
LID - 14933
AB  - Hepatitis B virus (HBV) infection is the predominant risk factor for chronic 
      hepatitis B (CHB), liver cirrhosis (LC) and hepatocellular carcinoma (HCC). 
      Recently, genome-wide association studies have identified human leukocyte antigen 
      (HLA)-DP polymorphisms (rs3077 and rs9277535) as a new chronic HBV infection 
      susceptibility locus. Since then, the relationship between HLA-DP polymorphisms 
      and various outcomes of HBV infection has been reported. However, the results 
      have been inconclusive. To derive a more precise estimation of the relationship 
      between HLA-DP polymorphisms and various outcomes of HBV infection, a 
      meta-analysis of 62,050 subjects from 29 case-control studies was performed. We 
      found that rs3077 and rs9277535 in HLA-DP significantly decreased HBV infection 
      risks and increased HBV clearance possibility in a dose-dependent manner. In the 
      subgroup analysis by ethnicity, study design and sample size, significant 
      associations were found for these polymorphisms in almost all comparisons. 
      Meanwhile, haplotype analyses of the two polymorphisms revealed a significant 
      association between the combination of these alleles and HBV infection outcomes. 
      However, no significant results were observed in HCC development. Our results 
      further confirm that genetic variants in the HLA-DP locus are strongly associated 
      with reduced HBV infection and increased the likelihood of spontaneous viral 
      clearance.
FAU - Yu, Lei
AU  - Yu L
AD  - The Affiliated Hospital, Guizhou Medical University, Beijing Road 9, Guiyang 
      550004, Guizhou, China.
FAU - Cheng, Yi-ju
AU  - Cheng YJ
AD  - The First Affiliated Hospital, Soochow University, Shizi Street 188, Suzhou 
      215006, Jiangsu, China.
FAU - Cheng, Ming-liang
AU  - Cheng ML
AD  - The Affiliated Hospital, Guizhou Medical University, Beijing Road 9, Guiyang 
      550004, Guizhou, China.
FAU - Yao, Yu-mei
AU  - Yao YM
AD  - The Affiliated Hospital, Guizhou Medical University, Beijing Road 9, Guiyang 
      550004, Guizhou, China.
FAU - Zhang, Quan
AU  - Zhang Q
AD  - The Affiliated Hospital, Guizhou Medical University, Beijing Road 9, Guiyang 
      550004, Guizhou, China.
FAU - Zhao, Xue-ke
AU  - Zhao XK
AD  - The Affiliated Hospital, Guizhou Medical University, Beijing Road 9, Guiyang 
      550004, Guizhou, China.
FAU - Liu, Hua-juan
AU  - Liu HJ
AD  - The Affiliated Hospital, Guizhou Medical University, Beijing Road 9, Guiyang 
      550004, Guizhou, China.
FAU - Hu, Ya-xin
AU  - Hu YX
AD  - The Affiliated Hospital, Guizhou Medical University, Beijing Road 9, Guiyang 
      550004, Guizhou, China.
FAU - Mu, Mao
AU  - Mu M
AD  - The Affiliated Hospital, Guizhou Medical University, Beijing Road 9, Guiyang 
      550004, Guizhou, China.
FAU - Wang, Bi
AU  - Wang B
AD  - The Affiliated Hospital, Guizhou Medical University, Beijing Road 9, Guiyang 
      550004, Guizhou, China.
AD  - Department of Eugenics and Genetics, Guiyang Maternal and Child Health-Care 
      Hospital, Ruijin South Road 63, Guiyang 550003, Guizhou, China.
FAU - Yang, Guo-zhen
AU  - Yang GZ
AD  - The Affiliated Hospital, Guizhou Medical University, Beijing Road 9, Guiyang 
      550004, Guizhou, China.
FAU - Zhu, Li-li
AU  - Zhu LL
AD  - The Affiliated Hospital, Guizhou Medical University, Beijing Road 9, Guiyang 
      550004, Guizhou, China.
FAU - Zhang, Shuai
AU  - Zhang S
AD  - The Affiliated Hospital, Guizhou Medical University, Beijing Road 9, Guiyang 
      550004, Guizhou, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Multicenter Study
DEP - 20151014
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (HLA-DP Antigens)
SB  - IM
MH  - Carcinoma, Hepatocellular/epidemiology/*genetics/virology
MH  - Causality
MH  - China/epidemiology
MH  - Comorbidity
MH  - Female
MH  - Genetic Predisposition to Disease/epidemiology/genetics
MH  - Genetic Variation/genetics
MH  - Genome-Wide Association Study
MH  - HLA-DP Antigens/*genetics
MH  - Hepatitis B/*epidemiology/*genetics/virology
MH  - Humans
MH  - Liver Neoplasms/*epidemiology/*genetics/virology
MH  - Male
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Precancerous Conditions
MH  - Prevalence
MH  - Risk Assessment
MH  - Virus Latency/genetics
PMC - PMC4604517
EDAT- 2015/10/16 06:00
MHDA- 2016/08/16 06:00
PMCR- 2015/10/14
CRDT- 2015/10/15 06:00
PHST- 2015/03/19 00:00 [received]
PHST- 2015/09/11 00:00 [accepted]
PHST- 2015/10/15 06:00 [entrez]
PHST- 2015/10/16 06:00 [pubmed]
PHST- 2016/08/16 06:00 [medline]
PHST- 2015/10/14 00:00 [pmc-release]
AID - srep14933 [pii]
AID - 10.1038/srep14933 [doi]
PST - epublish
SO  - Sci Rep. 2015 Oct 14;5:14933. doi: 10.1038/srep14933.