PMID- 26462756
OWN - NLM
STAT- MEDLINE
DCOM- 20160210
LR  - 20220410
IS  - 1471-0048 (Electronic)
IS  - 1471-003X (Linking)
VI  - 16
IP  - 11
DP  - 2015 Nov
TI  - Hippocampal insulin resistance and cognitive dysfunction.
PG  - 660-71
LID - 10.1038/nrn4019 [doi]
AB  - Clinical studies suggest a link between type 2 diabetes mellitus (T2DM) and 
      insulin resistance (IR) and cognitive dysfunction, but there are significant gaps 
      in our knowledge of the mechanisms underlying this relationship. Animal models of 
      IR help to bridge these gaps and point to hippocampal IR as a potential mediator 
      of cognitive dysfunction in T2DM, as well as in Alzheimer disease (AD). This 
      Review highlights these observations and discusses intervention studies which 
      suggest that the restoration of insulin activity in the hippocampus may be an 
      effective strategy to alleviate the cognitive decline associated with T2DM and 
      AD.
FAU - Biessels, Geert Jan
AU  - Biessels GJ
AD  - Department of Neurology, G03.232, Brain Center Rudolf Magnus, University Medical 
      Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands.
FAU - Reagan, Lawrence P
AU  - Reagan LP
AD  - Department of Pharmacology, Physiology and Neuroscience, University of South 
      Carolina School of Medicine, 6439 Garners Ferry Road, VA Building 1, Room D40, 
      Columbia, South Carolina 29208, USA.
AD  - Wm. Jennings Bryan Dorn Veterans Affairs Medical Center, 6439 Garners Ferry Road, 
      VA Building 9, Room 206, Columbia, South Carolina 29208, USA.
LA  - eng
GR  - I01 BX001804/BX/BLRD VA/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
DEP - 20151014
PL  - England
TA  - Nat Rev Neurosci
JT  - Nature reviews. Neuroscience
JID - 100962781
SB  - IM
MH  - Animals
MH  - Cognition Disorders/*metabolism/pathology/*psychology
MH  - Diabetes Mellitus, Type 2/*metabolism/pathology/*psychology
MH  - Disease Models, Animal
MH  - Hippocampus/*metabolism/pathology
MH  - Humans
MH  - Insulin Resistance/*physiology
EDAT- 2015/10/16 06:00
MHDA- 2016/02/11 06:00
CRDT- 2015/10/15 06:00
PHST- 2015/10/15 06:00 [entrez]
PHST- 2015/10/16 06:00 [pubmed]
PHST- 2016/02/11 06:00 [medline]
AID - nrn4019 [pii]
AID - 10.1038/nrn4019 [doi]
PST - ppublish
SO  - Nat Rev Neurosci. 2015 Nov;16(11):660-71. doi: 10.1038/nrn4019. Epub 2015 Oct 14.