PMID- 26464258
OWN - NLM
STAT- MEDLINE
DCOM- 20160225
LR  - 20180608
IS  - 0895-3988 (Print)
IS  - 0895-3988 (Linking)
VI  - 28
IP  - 9
DP  - 2015 Sep
TI  - Assessing Adverse Effects of Aroclor 1254 on Perinatally Exposed Rat Offspring.
PG  - 687-90
LID - 10.3967/bes2015.097 [doi]
AB  - To assess the neurotoxic effects and redox responses of Aroclor 1254 (A1254) on 
      perinatally exposed rat offspring, A1254 was administered by gavage from 
      gestational day (GD) 6 to postnatal day (PND) 21. Neurobehavioral development, 
      antioxidant enzyme activities, lipid peroxidation (LPO), nitric oxide (NO), and 
      NO synthase (NOS) levels were analyzed in the offspring. Neurobehavioral 
      development analysis revealed delayed appearance of the righting reflex, negative 
      geotaxis, and cliff drop test responses in A1254 exposed group. Developmental 
      A1254 exposure also caused oxidative stress in the brain of PND 22 offspring via 
      reductions in the activity of SOD and GSH-Px, and by promoting a rise in the 
      levels of NO and NOS.
CI  - Copyright (c) 2015 The Editorial Board of Biomedical and Environmental Sciences. 
      Published by China CDC. All rights reserved.
FAU - Tang, Wei
AU  - Tang W
AD  - School of Environmental Science and Engineering, Shanghai Jiao Tong University, 
      Shanghai 200240, China.
FAU - Cheng, Jin Ping
AU  - Cheng JP
AD  - School of Environmental Science and Engineering, Shanghai Jiao Tong University, 
      Shanghai 200240, China.
FAU - Yang, Yi Chen
AU  - Yang YC
AD  - School of Environmental Science and Engineering, Shanghai Jiao Tong University, 
      Shanghai 200240, China.
FAU - Wang, Wen Hua
AU  - Wang WH
AD  - School of Environmental Science and Engineering, Shanghai Jiao Tong University, 
      Shanghai 200240, China.
LA  - eng
PT  - Letter
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Biomed Environ Sci
JT  - Biomedical and environmental sciences : BES
JID - 8909524
RN  - 11097-69-1 (Chlorodiphenyl (54% Chlorine))
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
SB  - IM
MH  - Aging/metabolism
MH  - Animals
MH  - Cerebral Cortex/drug effects/enzymology/metabolism
MH  - Chlorodiphenyl (54% Chlorine)/*toxicity
MH  - Female
MH  - Glutathione Peroxidase/metabolism
MH  - Kidney/drug effects/enzymology/metabolism
MH  - Lipid Peroxidation/drug effects
MH  - Liver/drug effects/enzymology/metabolism
MH  - Mice
MH  - Nervous System/*drug effects/growth & development/metabolism/physiopathology
MH  - Nervous System Diseases/*chemically induced
MH  - Nitric Oxide/metabolism
MH  - Nitric Oxide Synthase/metabolism
MH  - Oxidative Stress/drug effects
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*chemically induced
MH  - Random Allocation
MH  - Rats
MH  - Superoxide Dismutase/metabolism
EDAT- 2015/10/16 06:00
MHDA- 2016/02/26 06:00
CRDT- 2015/10/15 06:00
PHST- 2015/02/02 00:00 [received]
PHST- 2015/09/10 00:00 [accepted]
PHST- 2015/10/15 06:00 [entrez]
PHST- 2015/10/16 06:00 [pubmed]
PHST- 2016/02/26 06:00 [medline]
AID - S0895-3988(15)30096-9 [pii]
AID - 10.3967/bes2015.097 [doi]
PST - ppublish
SO  - Biomed Environ Sci. 2015 Sep;28(9):687-90. doi: 10.3967/bes2015.097.