PMID- 26464329
OWN - NLM
STAT- MEDLINE
DCOM- 20160617
LR  - 20181202
IS  - 1361-6560 (Electronic)
IS  - 0031-9155 (Linking)
VI  - 60
IP  - 21
DP  - 2015 Nov 7
TI  - Quantitative representation and description of intravoxel fiber complexity in 
      HARDI.
PG  - 8417-36
LID - 10.1088/0031-9155/60/21/8417 [doi]
AB  - Diffusion tensor imaging and high angular resolution diffusion imaging are often 
      used to analyze the fiber complexity of tissues. In these imaging techniques, the 
      most commonly calculated metric is anisotropy, such as fractional anisotropy 
      (FA), generalized anisotropy (GA), and generalized fractional anisotropy (GFA). 
      The basic idea underlying these metrics is to compute the deviation from free or 
      spherical diffusion. However, in many cases, the question is not really to know 
      whether it concerns spherical diffusion. Instead, the main concern is to describe 
      and quantify fiber complexity such as fiber crossing in a voxel. In this context, 
      it would be more direct and effective to compute the deviation from a single 
      fiber bundle instead of a sphere. We propose a new metric, called PEAM (PEAnut 
      Metric), which is based on computing the deviation of orientation diffusion 
      functions (ODFs) from a single fiber bundle ODF represented by a peanut. As an 
      example, the proposed PEAM metric is used to classify intravoxel fiber 
      configurations. The results on simulated data, physical phantom data and real 
      brain data consistently showed that the proposed PEAM provides greater accuracy 
      than FA, GA and GFA and enables parallel and complex fibers to be better 
      distinguished.
FAU - Sun, Chang-yu
AU  - Sun CY
AD  - CREATIS, CNRS UMR 5220, Inserm U1044, INSA of Lyon, University of Lyon, 
      Villeurbanne 69100, France. CNRS LIA Metislab, Harbin Institute of Technology, 
      Harbin 150001, People's Republic of China.
FAU - Chu, Chun-yu
AU  - Chu CY
FAU - Liu, Wan-yu
AU  - Liu WY
FAU - Hsu, Edward W
AU  - Hsu EW
FAU - Korenberg, Julie R
AU  - Korenberg JR
FAU - Zhu, Yue-min
AU  - Zhu YM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151014
PL  - England
TA  - Phys Med Biol
JT  - Physics in medicine and biology
JID - 0401220
SB  - IM
MH  - *Algorithms
MH  - Anisotropy
MH  - Diffusion Magnetic Resonance Imaging/*methods
MH  - Diffusion Tensor Imaging/*methods
EDAT- 2015/10/16 06:00
MHDA- 2016/06/18 06:00
CRDT- 2015/10/15 06:00
PHST- 2015/10/15 06:00 [entrez]
PHST- 2015/10/16 06:00 [pubmed]
PHST- 2016/06/18 06:00 [medline]
AID - 10.1088/0031-9155/60/21/8417 [doi]
PST - ppublish
SO  - Phys Med Biol. 2015 Nov 7;60(21):8417-36. doi: 10.1088/0031-9155/60/21/8417. Epub 
      2015 Oct 14.