PMID- 26464952
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151014
LR  - 20220408
IS  - 2356-7708 (Print)
IS  - 2314-6966 (Electronic)
IS  - 2314-6966 (Linking)
VI  - 2015
DP  - 2015
TI  - An Antioxidant Dietary Supplement Improves Brain-Derived Neurotrophic Factor 
      Levels in Serum of Aged Dogs: Preliminary Results.
PG  - 412501
LID - 10.1155/2015/412501 [doi]
LID - 412501
AB  - Biological aging is characterized by a progressive accumulation of oxidative 
      damage and decreased endogenous antioxidant defense mechanisms. The production of 
      oxidants by normal metabolism damages proteins, lipids, and nucleotides, which 
      may contribute to cognitive impairment. In this study 36 dogs were randomly 
      divided into four groups and fed croquettes of different compositions for 6 
      months. We monitored derivatives of reactive oxygen metabolites (dROMs) and 
      biological antioxidant potential (BAP) levels in dogs' plasma samples as well as 
      brain-derived neurotrophic factor (BDNF) serum levels at the beginning and at the 
      end of the dietary regime. Our results showed that a dietary regime, enriched 
      with antioxidants, induced a significant decrease of plasma levels of dROMs (p < 
      0.005) and a significant increase in BDNF serum levels (p < 0.005) after six 
      months. Thus, we hypothesized a possible role of the diet in modulating pro- and 
      antioxidant species as well as BDNF levels in plasma and serum, respectively. In 
      conclusion the proposed diet enriched with antioxidants might be considered a 
      valid alternative and a valuable strategy to counteract aging-related cognitive 
      decline in elderly dogs.
FAU - Sechi, Sara
AU  - Sechi S
AD  - Department of Veterinary Medicine, Pathology and Veterinary Clinic Section, Via 
      Vienna 2, 07100 Sassari, Italy.
FAU - Chiavolelli, Francesca
AU  - Chiavolelli F
AD  - SANYpet S.p.a., Research and Development Department, Via Austria 3, Bagnoli di 
      Sopra, 35023 Padua, Italy.
FAU - Spissu, Nicoletta
AU  - Spissu N
AD  - Department of Veterinary Medicine, Pathology and Veterinary Clinic Section, Via 
      Vienna 2, 07100 Sassari, Italy.
FAU - Di Cerbo, Alessandro
AU  - Di Cerbo A
AD  - School of Specialization in Clinical Biochemistry, "G. d'Annunzio" University, 
      Via dei Vestini 31, 66100 Chieti, Italy.
FAU - Canello, Sergio
AU  - Canello S
AD  - SANYpet S.p.a., Research and Development Department, Via Austria 3, Bagnoli di 
      Sopra, 35023 Padua, Italy.
FAU - Guidetti, Gianandrea
AU  - Guidetti G
AD  - SANYpet S.p.a., Research and Development Department, Via Austria 3, Bagnoli di 
      Sopra, 35023 Padua, Italy.
FAU - Fiore, Filippo
AU  - Fiore F
AD  - Department of Veterinary Medicine, Pathology and Veterinary Clinic Section, Via 
      Vienna 2, 07100 Sassari, Italy.
FAU - Cocco, Raffaella
AU  - Cocco R
AD  - Department of Veterinary Medicine, Pathology and Veterinary Clinic Section, Via 
      Vienna 2, 07100 Sassari, Italy.
LA  - eng
PT  - Journal Article
DEP - 20150623
PL  - United States
TA  - J Vet Med
JT  - Journal of veterinary medicine
JID - 101627989
PMC - PMC4590864
EDAT- 2015/10/16 06:00
MHDA- 2015/10/16 06:01
PMCR- 2015/06/23
CRDT- 2015/10/15 06:00
PHST- 2015/03/23 00:00 [received]
PHST- 2015/06/01 00:00 [revised]
PHST- 2015/06/07 00:00 [accepted]
PHST- 2015/10/15 06:00 [entrez]
PHST- 2015/10/16 06:00 [pubmed]
PHST- 2015/10/16 06:01 [medline]
PHST- 2015/06/23 00:00 [pmc-release]
AID - 10.1155/2015/412501 [doi]
PST - ppublish
SO  - J Vet Med. 2015;2015:412501. doi: 10.1155/2015/412501. Epub 2015 Jun 23.