PMID- 26465365
OWN - NLM
STAT- MEDLINE
DCOM- 20160329
LR  - 20181113
IS  - 1678-9946 (Electronic)
IS  - 0036-4665 (Print)
IS  - 0036-4665 (Linking)
VI  - 57 Suppl 19
IP  - Suppl 19
DP  - 2015 Sep
TI  - PARACOCCIDIOIDOMYCOSIS: CHALLENGES IN THE DEVELOPMENT OF A VACCINE AGAINST AN 
      ENDEMIC MYCOSIS IN THE AMERICAS.
PG  - 21-4
LID - S0036-46652015000800021 [pii]
LID - 10.1590/S0036-46652015000700005 [doi]
AB  - Paracoccidioidomycosis (PCM), caused by Paracoccidioides spp, is an important 
      endemic mycosis in Latin America. There are two recognized Paracoccidioides 
      species, P. brasiliensis and P. lutzii, based on phylogenetic differences; 
      however, the pathogenesis and disease manifestations of both are 
      indistinguishable at present. Approximately 1,853 (~51,2%) of 3,583 confirmed 
      deaths in Brazil due to systemic mycoses from 1996-2006 were caused by PCM. 
      Antifungal treatment is required for patients with PCM. The initial treatment 
      lasts from two to six months and sulfa derivatives, amphotericin B, azoles and 
      terbinafine are used in clinical practice; however, despite prolonged therapy, 
      relapses are still a problem. An effective Th1-biased cellular immune response is 
      essential to control the disease, which can be induced by exogenous antigens or 
      modulated by prophylactic or therapeutic vaccines. Stimulation of B cells or 
      passive transference of monoclonal antibodies are also important means that may 
      be used to improve the efficacy of paracoccidioidomycosis treatment in the 
      future. This review critically details major challenges facing the development of 
      a vaccine to combat PCM.
FAU - Taborda, Carlos P
AU  - Taborda CP
AD  - Universidade de Sao Paulo, Sao Paulo, SP, Brasil.
FAU - Uran, M E
AU  - Uran ME
AD  - Instituto de Medicina Tropical, Universidade de Sao Paulo, Sao Paulo, SP, Brasil.
FAU - Nosanchuk, J D
AU  - Nosanchuk JD
AD  - Departments of Medicine, Division of Infectious Diseases and Microbiology and 
      Immunology, Albert Einstein College of Medicine, Bronx, NY, U.S.A.
FAU - Travassos, L R
AU  - Travassos LR
AD  - Departmento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de 
      Sao Paulo, Sao Paulo, SP, Brasil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Brazil
TA  - Rev Inst Med Trop Sao Paulo
JT  - Revista do Instituto de Medicina Tropical de Sao Paulo
JID - 7507484
RN  - 0 (Antigens, Fungal)
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (Fungal Vaccines)
RN  - 0 (Glycoproteins)
RN  - 0 (P10 peptide, Paracoccidioides brasiliensis)
RN  - 0 (Peptide Fragments)
RN  - 0 (Vaccines, DNA)
RN  - 0 (tumor-associated antigen, gp43)
SB  - IM
MH  - Animals
MH  - Antigens, Fungal/*immunology
MH  - Antigens, Neoplasm/immunology
MH  - Fungal Vaccines/*immunology
MH  - Glycoproteins/immunology
MH  - Humans
MH  - Mice
MH  - Paracoccidioides/*immunology
MH  - Paracoccidioidomycosis/immunology/*therapy
MH  - Peptide Fragments/immunology
MH  - Vaccines, DNA/*immunology
PMC - PMC4711196
EDAT- 2015/10/16 06:00
MHDA- 2016/03/30 06:00
PMCR- 2015/09/01
CRDT- 2015/10/15 06:00
PHST- 2015/10/15 06:00 [entrez]
PHST- 2015/10/16 06:00 [pubmed]
PHST- 2016/03/30 06:00 [medline]
PHST- 2015/09/01 00:00 [pmc-release]
AID - S0036-46652015000800021 [pii]
AID - 10.1590/S0036-46652015000700005 [doi]
PST - ppublish
SO  - Rev Inst Med Trop Sao Paulo. 2015 Sep;57 Suppl 19(Suppl 19):21-4. doi: 
      10.1590/S0036-46652015000700005.