PMID- 26466692
OWN - NLM
STAT- MEDLINE
DCOM- 20160427
LR  - 20181202
IS  - 1349-7235 (Electronic)
IS  - 0918-2918 (Linking)
VI  - 54
IP  - 20
DP  - 2015
TI  - Angiotensin-converting enzyme inhibitor-induced angioedema and hereditary 
      angioedema: a comparison study of attack severity.
PG  - 2583-8
LID - 10.2169/internalmedicine.54.4181 [doi]
AB  - Objective There appears to be differences in the clinical presentation of 
      hereditary angioedema (HAE) and angiotensin-converting enzyme inhibitor-induced 
      (ACE-I) angioedema (AE). The aim of this study was to compare the clinical 
      characteristics of these two AE forms. Methods We conducted a retrospective study 
      of consecutive patients with HAE or ACE-I AE. The attack characteristics 
      experienced by the patients were compared by a logistic regression analysis using 
      generalized estimating equations. Results A total of 56 patients were included in 
      this study (ACE-I AE, n=25; HAE, n=31). A total of 534 attacks were documented. 
      Severe attacks were more common in the patients who had an acute episode of ACE-I 
      AE than HAE. Swelling of the tongue, lips and larynx were significantly 
      associated with ACE-I AE [OR: 8.70 (95% CI, 1.04-73.70), OR: 20.4 (95% CI, 
      4.9-84.2) and OR: 7.50 (95% CI, 1.20-48.30), respectively]. Conclusion Swelling 
      of the tongue, lips and larynx are significantly more frequent in drug-induced AE 
      than HAE.
FAU - Javaud, Nicolas
AU  - Javaud N
AD  - Emergency Department, Angioedema Reference Center (CReAk), Public Assistance 
      Hospital of Paris, University Hospital of Jean Verdier, France.
FAU - Charpentier, Stephane
AU  - Charpentier S
FAU - Lapostolle, Frederic
AU  - Lapostolle F
FAU - Lekouara, Hakim
AU  - Lekouara H
FAU - Boubaya, Marouane
AU  - Boubaya M
FAU - Lenoir, Gilles
AU  - Lenoir G
FAU - Mekinian, Arsene
AU  - Mekinian A
FAU - Adnet, Frederic
AU  - Adnet F
FAU - Fain, Olivier
AU  - Fain O
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20151015
PL  - Japan
TA  - Intern Med
JT  - Internal medicine (Tokyo, Japan)
JID - 9204241
RN  - 0 (Angiotensin-Converting Enzyme Inhibitors)
RN  - 0 (Immunosuppressive Agents)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Angioedema/chemically induced/diagnosis/*pathology
MH  - Angioedemas, Hereditary/diagnosis/*pathology
MH  - Angiotensin-Converting Enzyme Inhibitors/administration & dosage/*adverse effects
MH  - Female
MH  - Humans
MH  - Immunosuppressive Agents/adverse effects
MH  - Larynx/drug effects/*pathology
MH  - Lip/drug effects/*pathology
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Severity of Illness Index
MH  - Tongue/drug effects/*pathology
MH  - Young Adult
EDAT- 2015/10/16 06:00
MHDA- 2016/04/28 06:00
CRDT- 2015/10/16 06:00
PHST- 2015/10/16 06:00 [entrez]
PHST- 2015/10/16 06:00 [pubmed]
PHST- 2016/04/28 06:00 [medline]
AID - 10.2169/internalmedicine.54.4181 [doi]
PST - ppublish
SO  - Intern Med. 2015;54(20):2583-8. doi: 10.2169/internalmedicine.54.4181. Epub 2015 
      Oct 15.