PMID- 26467370
OWN - NLM
STAT- MEDLINE
DCOM- 20161219
LR  - 20191210
IS  - 2149-2271 (Electronic)
IS  - 2149-2263 (Print)
IS  - 2149-2263 (Linking)
VI  - 16
IP  - 2
DP  - 2016 Feb
TI  - Diagnostic performance of late gadolinium enhancement in the assessment of acute 
      cellular rejection after heart transplantation.
PG  - 113-8
LID - 10.5152/AnatolJCardiol.2015.5961 [doi]
AB  - OBJECTIVE: Allograft rejection is still an important cause of morbidity and 
      mortality after heart transplantation (HTx). Many techniques in cardiac magnetic 
      resonance imaging (CMR) were investigated to diagnose acute cellular rejection 
      (ACR). However, there is not enough information about late gadolinium enhancement 
      (LGE) in the myocardium and ACR. METHODS: We prospectively analyzed our 
      consecutive 41 heart transplant recipients who were admitted for routine 
      endomyocardial biopsies. CMR was performed maximum 6 h before the scheduled 
      endomyocardial biopsy. Correlation between LGE in the myocardium and ACR was 
      investigated. RESULTS: Twenty-seven patients showed no rejection, and nine of 
      them had LGE in the myocardium. Fourteen patients had LGE in the left ventricle 
      (LV), and two patients had LGE also in the right ventricle (RV). There was no 
      correlation between LGE and ACR (p=0.879). There was no difference in the left 
      ventricular ejection fraction (LVEF), right ventricular fractional area change 
      (RVFAC), and cardiac ischemic time between the groups (p=0.825, p=0.370, and 
      p=0.419, respectively). LGE in the myocardium could be due to previous rejection 
      episodes; therefore, all patients were retrospectively searched for previous 
      rejection grades and number of episodes. Thirty-eight of the 41 patients had a 
      history of one ACR episode, but none of them had a statistically significant 
      correlation with LGE (for grade 1R, p=0.964 and grade 3R, p=1) There was also no 
      correlation between number of rejection episodes history and LGE. CONCLUSION: LGE 
      is not suitable to detect ACR in heart transplant patients. LGE and the history 
      of ACR have no correlation.
FAU - Simsek, Evrim
AU  - Simsek E
AD  - Department of Cardiology, Faculty of Medicine, Ege University; Izmir-Turkey. 
      drevrimsimsek@gmail.com.
FAU - Nalbantgil, Sanem
AU  - Nalbantgil S
FAU - Ceylan, Naim
AU  - Ceylan N
FAU - Zoghi, Mehdi
AU  - Zoghi M
FAU - Kemal, Hatice Soner
AU  - Kemal HS
FAU - Engin, Cagatay
AU  - Engin C
FAU - Yagdi, Tahir
AU  - Yagdi T
FAU - Ozbaran, Mustafa
AU  - Ozbaran M
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20150618
PL  - Turkey
TA  - Anatol J Cardiol
JT  - Anatolian journal of cardiology
JID - 101652981
RN  - 0 (Contrast Media)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Adult
MH  - Contrast Media/*administration & dosage
MH  - Female
MH  - Gadolinium DTPA/*administration & dosage
MH  - Graft Rejection/*diagnostic imaging
MH  - *Heart Transplantation
MH  - Humans
MH  - Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Predictive Value of Tests
MH  - Prospective Studies
PMC - PMC5336724
COIS- Conflict of interest: None declared.
EDAT- 2015/10/16 06:00
MHDA- 2016/12/20 06:00
PMCR- 2016/02/01
CRDT- 2015/10/16 06:00
PHST- 2015/10/16 06:00 [entrez]
PHST- 2015/10/16 06:00 [pubmed]
PHST- 2016/12/20 06:00 [medline]
PHST- 2016/02/01 00:00 [pmc-release]
AID - AJC-16-113 [pii]
AID - 10.5152/AnatolJCardiol.2015.5961 [doi]
PST - ppublish
SO  - Anatol J Cardiol. 2016 Feb;16(2):113-8. doi: 10.5152/AnatolJCardiol.2015.5961. 
      Epub 2015 Jun 18.