PMID- 26468183
OWN - NLM
STAT- MEDLINE
DCOM- 20160119
LR  - 20181113
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 35
IP  - 41
DP  - 2015 Oct 14
TI  - Dysregulation of Mammalian Target of Rapamycin Signaling in Mouse Models of 
      Autism.
PG  - 13836-42
LID - 10.1523/JNEUROSCI.2656-15.2015 [doi]
AB  - The mammalian target of rapamycin (mTOR) is a central regulator of a diverse 
      array of cellular processes, including cell growth, proliferation, autophagy, 
      translation, and actin polymerization. Components of the mTOR cascade are present 
      at synapses and influence synaptic plasticity and spine morphogenesis. A 
      prevailing view is that the study of mTOR and its role in autism spectrum 
      disorders (ASDs) will elucidate the molecular mechanisms by which mTOR regulates 
      neuronal function under physiological and pathological conditions. Although many 
      ASDs arise as a result of mutations in genes with multiple molecular functions, 
      they appear to converge on common biological pathways that give rise to 
      autism-relevant behaviors. Dysregulation of mTOR signaling has been identified as 
      a phenotypic feature common to fragile X syndrome, tuberous sclerosis complex 1 
      and 2, neurofibromatosis 1, phosphatase and tensin homolog, and potentially Rett 
      syndrome. Below are a summary of topics covered in a symposium that presents 
      dysregulation of mTOR as a unifying theme in a subset of ASDs.
CI  - Copyright (c) 2015 the authors 0270-6474/15/3513836-07$15.00/0.
FAU - Huber, Kimberly M
AU  - Huber KM
AD  - Department of Neuroscience, University of Texas Southwestern Medical Center, 
      Dallas, Texas 75390.
FAU - Klann, Eric
AU  - Klann E
AD  - Center for Neural Science, New York University, New York, New York 10003.
FAU - Costa-Mattioli, Mauro
AU  - Costa-Mattioli M
AD  - Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, 
      and.
FAU - Zukin, R Suzanne
AU  - Zukin RS
AD  - Dominick P. Purpura Department of Neuroscience, Albert Einstein College of 
      Medicine, New York, New York 10461 suzanne.zukin@einstein.yu.edu.
LA  - eng
GR  - R01 MH096816/MH/NIMH NIH HHS/United States
GR  - R01 NS045711/NS/NINDS NIH HHS/United States
GR  - R01 NS047384/NS/NINDS NIH HHS/United States
GR  - R01 NS076708/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - W36ZG6FT64 (Sirolimus)
SB  - IM
MH  - Animals
MH  - Autistic Disorder/*metabolism/*pathology/physiopathology
MH  - *Disease Models, Animal
MH  - Humans
MH  - Models, Biological
MH  - Signal Transduction/*physiology
MH  - Sirolimus/*metabolism
PMC - PMC4604222
OTO - NOTNLM
OT  - Fragile X syndromes
OT  - mTOR signaling
OT  - mouse models of autism
OT  - protein synthesis pathway
EDAT- 2015/10/16 06:00
MHDA- 2016/01/20 06:00
PMCR- 2016/04/14
CRDT- 2015/10/16 06:00
PHST- 2015/10/16 06:00 [entrez]
PHST- 2015/10/16 06:00 [pubmed]
PHST- 2016/01/20 06:00 [medline]
PHST- 2016/04/14 00:00 [pmc-release]
AID - 35/41/13836 [pii]
AID - 2656-15 [pii]
AID - 10.1523/JNEUROSCI.2656-15.2015 [doi]
PST - ppublish
SO  - J Neurosci. 2015 Oct 14;35(41):13836-42. doi: 10.1523/JNEUROSCI.2656-15.2015.