PMID- 26469919
OWN - NLM
STAT- MEDLINE
DCOM- 20160119
LR  - 20221005
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 94
IP  - 41
DP  - 2015 Oct
TI  - A Pediatric Acute Promyelocytic Leukemia With a Rare Karyotype of 
      ider(17)(q10)t(15;17) and Favorable Outcome: A Case Report.
PG  - e1778
LID - 10.1097/MD.0000000000001778 [doi]
LID - e1778
AB  - Acute promyelocytic leukemia (APL) is a specific malignant hematological disorder 
      with a diagnostic hallmark of chromosome translocation t(15;17)(q22;q21). As a 
      very rare secondary cytogenetic aberration in pediatric APL, ider(17q) 
      (q10)t(15;17) was suggested to be a poor prognostic factor based on previous case 
      reports.Here, we report a pediatric APL case with a rare karyotype of 
      ider(17)(q10)t(15;17). Bone marrow aspiration, immunophenotyping, molecular 
      biology, cytogenetic, and fluorescence in situ hybridization (FISH) analyses were 
      performed at initial diagnosis and during the treatment.A 6-year-old boy was 
      brought to our hospital with the chief complaint of bleeding gums twice and 
      intermittent fever for 3 days in January 2013. He was diagnosed as low-risk APL 
      according to the 2012 NCCN guideline on APL, with the expression of PML-RARA 
      (bcr3 subtype) and the karyotype of 46,XY, 
      der(15)t(15;17)(q22;q21),ider(17)(q10)t(15;17), which was further verified by 
      FISH. The patient was treated through combination all-trans retinoic acid (ATRA) 
      and arsenic with daunorubicin according to the 2012 NCCN guideline for APL. 
      Continuous hematological completed remission (HCR) and major molecular remission 
      (MMR) were achieved with normal karyotype for >28 months after induction 
      chemotherapy.Different from previously reported cases, this pediatric APL patient 
      with ider(17)(q10)t(15;17) displays favorable clinical outcomes, which might be 
      related to the low-risk classification and arsenic treatment during the 
      treatment. It suggests that ider(17)(q10)t(15;17) may not be the sole determinant 
      for worse outcomes in pediatric APL and implies that more contributed factors 
      should be considered for pediatric APL prognosis.
FAU - He, Yanli
AU  - He Y
AD  - From the Center for Stem Cell Research and Application, Institute of Hematology, 
      Union Hospital, Tongji Medical College, Huazhong University of Science and 
      Technology (YH, KL, XC, WD, JL, YH, WL, XL, JZ); Department of Clinical 
      Laboratory, Union Hospital, Tongji Medical College, Huazhong University of 
      Science and Technology (PW); Department of Pediatric, Union Hospital, Tongji 
      Medical College, Huazhong University of Science and Technology (YB, RJ); and 
      Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China (MZ).
FAU - Wang, Ping
AU  - Wang P
FAU - Liang, Kaiwei
AU  - Liang K
FAU - Chen, Xiangjun
AU  - Chen X
FAU - Du, Wen
AU  - Du W
FAU - Li, Juan
AU  - Li J
FAU - Hu, Yanjie
AU  - Hu Y
FAU - Bai, Yan
AU  - Bai Y
FAU - Liu, Wei
AU  - Liu W
FAU - Li, Xiaoqing
AU  - Li X
FAU - Jin, Runming
AU  - Jin R
FAU - Zhang, Min
AU  - Zhang M
FAU - Zheng, Jine
AU  - Zheng J
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
SB  - IM
MH  - Antineoplastic Combined Chemotherapy Protocols/therapeutic use
MH  - Child
MH  - Chromosome Aberrations
MH  - *Chromosomes, Human, Pair 15
MH  - *Chromosomes, Human, Pair 17
MH  - Humans
MH  - Immunophenotyping
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Leukemia, Promyelocytic, Acute/drug therapy/*genetics
MH  - Male
MH  - Polymerase Chain Reaction
MH  - Translocation, Genetic
PMC - PMC4616798
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2015/10/16 06:00
MHDA- 2016/01/20 06:00
PMCR- 2015/10/16
CRDT- 2015/10/16 06:00
PHST- 2015/10/16 06:00 [entrez]
PHST- 2015/10/16 06:00 [pubmed]
PHST- 2016/01/20 06:00 [medline]
PHST- 2015/10/16 00:00 [pmc-release]
AID - 00005792-201510020-00031 [pii]
AID - 10.1097/MD.0000000000001778 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2015 Oct;94(41):e1778. doi: 10.1097/MD.0000000000001778.