PMID- 26472267
OWN - NLM
STAT- MEDLINE
DCOM- 20161013
LR  - 20220331
IS  - 1651-2251 (Electronic)
IS  - 0001-6489 (Linking)
VI  - 136
IP  - 2
DP  - 2016
TI  - Estimation of the efficacy of chemo-radiotherapy on tumor regression in the 
      patients with laryngeal cancer via computerized tomography using the Cavalieri 
      method.
PG  - 164-7
LID - 10.3109/00016489.2015.1096958 [doi]
AB  - CONCLUSION: Calculating tumor volume using the Cavalieri method in laryngeal 
      tumors before and after treatment may be useful to optimize the treatment and to 
      minimize the side-effects of radiotherapy. PURPOSE: This study aimed to estimate 
      the pre-treatment and post-treatment tumor volumes of the patients to whom 
      radiotherapy or radio-chemotherapy was applied as a treatment using Cavalieri's 
      Principle as a stereological method and to assess tumor regression rates in the 
      patients with Laryngeal Squamous Cell Carcinoma (LSCC) statistically. MATERIALS 
      AND METHOD: Sixteen patients (eight patients with stage T3 and eight patients 
      with stage T4) diagnosed with LCCC bearing the appropriate characteristics to 
      criteria in the otorhinolaryngology clinic were included. Patients had 
      computerized tomography (CT) scans in the axial plane before treatment and 2 
      months after the treatment. Pre-treatment and post-treatment tumor volumes on CT 
      images were calculated using Cavalieri's principle as a stereological method and 
      then compared. FINDINGS: Average tumor volumes in patients with stage T3 before 
      and after treatment were 10.12 +/- 3.58 cm(3) and 1.33 +/- 1.74 cm(3), respectively 
      (p = 0.008). These volumes were 11.92 +/- 4.61 cm(3) and 2.17 +/- 2.34 cm(3) 
      (p = 0.008) for patients with stage T4, respectively. Post-treatment tumor 
      volumes were statistically reduced compared to pre-treatment volumes in all 
      stages.
FAU - Bingol, Fatih
AU  - Bingol F
AD  - a Department of Otorhinolaryngology , Ataturk University, School of Medicine , 
      Erzurum , Turkey ;
FAU - Yoruk, Ozgur
AU  - Yoruk O
AD  - a Department of Otorhinolaryngology , Ataturk University, School of Medicine , 
      Erzurum , Turkey ;
FAU - Bingol, Buket Ozel
AU  - Bingol BO
AD  - a Department of Otorhinolaryngology , Ataturk University, School of Medicine , 
      Erzurum , Turkey ;
FAU - Erdemci, Burak
AU  - Erdemci B
AD  - b Department of Radiation Oncology , Ataturk University, School of Medicine , 
      Erzurum , Turkey.
FAU - Ozkan, Ozalkan
AU  - Ozkan O
AD  - a Department of Otorhinolaryngology , Ataturk University, School of Medicine , 
      Erzurum , Turkey ;
FAU - Mazlumoglu, Muhammet Recai
AU  - Mazlumoglu MR
AD  - a Department of Otorhinolaryngology , Ataturk University, School of Medicine , 
      Erzurum , Turkey ;
LA  - eng
PT  - Journal Article
DEP - 20151015
PL  - England
TA  - Acta Otolaryngol
JT  - Acta oto-laryngologica
JID - 0370354
SB  - IM
MH  - Carcinoma, Squamous Cell/diagnostic imaging/pathology/*therapy
MH  - Chemoradiotherapy
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Laryngeal Neoplasms/diagnostic imaging/pathology/*therapy
MH  - Male
MH  - Middle Aged
MH  - *Models, Theoretical
MH  - Neoplasm Staging/*methods
MH  - Time Factors
MH  - Tomography, X-Ray Computed/methods
MH  - Treatment Outcome
MH  - Tumor Burden
OTO - NOTNLM
OT  - Cavalieri
OT  - Laryngeal squamous cell carcinoma
OT  - radiotherapy
OT  - stereology
EDAT- 2015/10/17 06:00
MHDA- 2016/10/14 06:00
CRDT- 2015/10/17 06:00
PHST- 2015/10/17 06:00 [entrez]
PHST- 2015/10/17 06:00 [pubmed]
PHST- 2016/10/14 06:00 [medline]
AID - 10.3109/00016489.2015.1096958 [doi]
PST - ppublish
SO  - Acta Otolaryngol. 2016;136(2):164-7. doi: 10.3109/00016489.2015.1096958. Epub 
      2015 Oct 15.