PMID- 26473291
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20220409
IS  - 1949-2553 (Electronic)
IS  - 1949-2553 (Linking)
VI  - 7
IP  - 3
DP  - 2016 Jan 19
TI  - Tolerability and efficacy of gamma knife radiosurgery on hepatocellular carcinoma 
      with portal vein tumor thrombosis.
PG  - 3614-22
LID - 10.18632/oncotarget.6118 [doi]
AB  - This is a retrospective study on the safety and efficacy of gamma knife 
      radiosurgery (GKR) in treating hepatocellular carcinoma (HCC) with portal vein 
      tumor thrombosis (PVTT). Patients with confirmed HCC and PVTT were allocated into 
      two groups based on the treatments they received (palliative or GKR). A total of 
      138 patients were included (74 in the palliative group, 64 in GKR group). No 
      significant differences in baseline characteristics existed between the two 
      groups. Treatment-related adverse events (AEs) were recorded and compared between 
      groups. The majority of AEs were mild to moderate and subsided naturally or after 
      medication. There was no AE-induced death. The influences of baseline 
      characteristics and treatment options on patients' OS were analyzed. The median 
      OS of patients in the palliative and GKR group were 3.0 months (95% CI: 
      2.719-3.281) and 6.1 months (95% CI: 4.706-7.494) respectively (p = 0.003). 
      Multivariate analysis revealed that GKR treatment, performance status 0-1, Child 
      A, smaller tumor diameter and monolobar distribution were significant favorable 
      prognosticators. Subgroup analyses showed OS benefit of GKR regardless of PVTT 
      location (main or branch of PVTT). In conclusion, GKR is well tolerated in 
      selected HCC-PVTT patients and can confer OS benefit, which needs validation in 
      future prospective studies.
FAU - Lu, Xiao-Jie
AU  - Lu XJ
AD  - Department of Gastroenterology, Shanghai East Hospital, Tongji University School 
      of Medicine, Shanghai, China.
FAU - Dong, Jing
AU  - Dong J
AD  - Outpatient Department, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang 
      Province, China.
FAU - Ji, Li-Juan
AU  - Ji LJ
AD  - Department of Rehabilitation, The Affiliated Huai'an Hospital of Xuzhou Medical 
      College and The Second People's Hospital of Huai'an, Huai'an, China.
FAU - Xiao, Li-Xin
AU  - Xiao LX
AD  - Department of Gamma Knife, The 411st Hospital of Chinese People's Liberation 
      Army, Shanghai, China.
FAU - Ling, Chang-Quan
AU  - Ling CQ
AD  - Changhai Hospital of Traditional Chinese Medicine, Second Military Medical 
      University, Shanghai, China.
FAU - Zhou, Jun
AU  - Zhou J
AD  - Department of Oncology and Hematology, Shanghai East Hospital, Tongji University 
      School of Medicine, Shanghai, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Oncotarget
JT  - Oncotarget
JID - 101532965
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Carcinoma, Hepatocellular/complications/pathology/*surgery
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Liver Neoplasms/complications/pathology/*surgery
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Portal Vein/pathology/*surgery
MH  - Prognosis
MH  - *Radiosurgery
MH  - Retrospective Studies
MH  - Survival Rate
MH  - Venous Thrombosis/complications/pathology/*surgery
MH  - Young Adult
PMC - PMC4823131
OTO - NOTNLM
OT  - adverse events
OT  - gamma knife
OT  - hepatocellular carcinoma
OT  - overall survival
OT  - portal vein tumor thrombosis
COIS- CONFLICTS OF INTEREST None
EDAT- 2015/10/17 06:00
MHDA- 2016/12/15 06:00
PMCR- 2016/01/19
CRDT- 2015/10/17 06:00
PHST- 2015/08/14 00:00 [received]
PHST- 2015/09/24 00:00 [accepted]
PHST- 2015/10/17 06:00 [entrez]
PHST- 2015/10/17 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
PHST- 2016/01/19 00:00 [pmc-release]
AID - 6118 [pii]
AID - 10.18632/oncotarget.6118 [doi]
PST - ppublish
SO  - Oncotarget. 2016 Jan 19;7(3):3614-22. doi: 10.18632/oncotarget.6118.