PMID- 26473312
OWN - NLM
STAT- MEDLINE
DCOM- 20170103
LR  - 20170104
IS  - 1365-2133 (Electronic)
IS  - 0007-0963 (Linking)
VI  - 174
IP  - 3
DP  - 2016 Mar
TI  - Propranolol in the treatment of infantile haemangiomas: lessons from the European 
      Propranolol In the Treatment of Complicated Haemangiomas (PITCH) Taskforce 
      survey.
PG  - 594-601
LID - 10.1111/bjd.14233 [doi]
AB  - BACKGROUND: Oral propranolol is widely prescribed as first-line treatment for 
      infantile haemangiomas (IHs). Anecdotally, prescribing practice differs widely 
      between centres. OBJECTIVES: The Propranolol In the Treatment of Complicated 
      Haemangiomas (PITCH) Taskforce was founded to establish patterns of use of 
      propranolol in IHs. METHODS: Participating centres entered data on all of their 
      patients who had completed treatment with oral propranolol for IHs, using an 
      online data capture tool. RESULTS: The study cohort comprised 1097 children from 
      39 centres in eight European countries. 76.1% were female and 92.8% had a focal 
      IH, with the remainder showing a segmental, multifocal or indeterminate pattern. 
      The main indications for treatment were periocular location (29.3%), risk of 
      cosmetic disfigurement (21.1%) and ulceration and bleeding (20.6%). In total 
      69.2% of patients were titrated up to a maintenance regimen, which consisted of 2 
      mg kg(-1) per day (85.8%) in the majority of cases. 91.4% of patients had an 
      excellent or good response to treatment. Rebound growth occurred in 14.1% upon 
      stopping, of whom 53.9% were restarted and treatment response was recaptured in 
      91.6% of cases. While there was no significant difference in the treatment 
      response, comparing a daily maintenance dose of < 2 mg kg(-1) vs. 2 mg kg(-1) vs. 
      > 2 mg kg(-1) , the risk of adverse events was significantly higher: odds ratio 
      (OR) 1 vs. adjusted OR 0.70, 95% confidence interval (CI) 0.33-1.50, P = 0.36 vs. 
      OR 2.38, 95% CI 1.04-5.46, P = 0.04, Ptrend < 0.001. CONCLUSIONS: The PITCH 
      survey summarizes the use of oral propranolol across 39 European centres, in a 
      variety of IH phases, and could be used to inform treatment guidelines and the 
      design of an interventional study.
CI  - (c) 2015 British Association of Dermatologists.
FAU - Wedgeworth, E
AU  - Wedgeworth E
AD  - Department of Paediatric Dermatology, St John's Institute of Dermatology, Guy's 
      and St Thomas' Hospitals NHS Foundation Trust, London, U.K.
FAU - Glover, M
AU  - Glover M
AD  - Department of Paediatric Dermatology, Great Ormond Street Hospital NHS Foundation 
      Trust, London, U.K.
FAU - Irvine, A D
AU  - Irvine AD
AD  - National Children's Research Centre & Department of Paediatric Dermatology, Our 
      Lady's Children's Hospital, Dublin, Ireland.
FAU - Neri, I
AU  - Neri I
AD  - Dermatology Department of Experimental, Diagnostic and Specialty Medicine 
      (DIMES), S. Orsola-Malpighi Hospital, Bologna University, Bologna, Italy.
FAU - Baselga, E
AU  - Baselga E
AD  - Pediatric Dermatology Unit, Department of Dermatology, Hospital de la Santa Creu 
      i Sant Pau, Barcelona, Spain.
FAU - Clayton, T H
AU  - Clayton TH
AD  - Department of Paediatric Dermatology, Royal Manchester Children's Hospital, 
      Manchester, U.K.
FAU - Beattie, P E
AU  - Beattie PE
AD  - Department of Paediatric Dermatology, Royal Hospital for Children, Glasgow, U.K.
FAU - Bjerre, J V
AU  - Bjerre JV
AD  - Department of Paediatrics, University Hospital Aarhus, Aarhus, Denmark.
FAU - Burrows, N P
AU  - Burrows NP
AD  - Department of Dermatology, Addenbrooke's Hospital, Cambridge University Hospitals 
      NHS Foundation Trust, Cambridge, U.K.
FAU - Foelster-Holst, R
AU  - Foelster-Holst R
AD  - Department of Dermatology, University Hospital Schleswig-Holstein, Campus Kiel, 
      Germany.
FAU - Hedelund, L
AU  - Hedelund L
AD  - Department of Dermatology, University Hospital Aarhus, Aarhus, Denmark.
FAU - Hernandez-Martin, A
AU  - Hernandez-Martin A
AD  - Department of Dermatology, Hospital Infantil Nino Jesus, Madrid, Spain.
FAU - Audrain, H
AU  - Audrain H
AD  - Department of Paediatric Dermatology, University Hospitals Bristol NHS Foundation 
      Trust, Bristol, U.K.
FAU - Bhate, K
AU  - Bhate K
AD  - Department of Paediatric Dermatology, Nottingham Children's Hospital, Nottingham, 
      U.K.
FAU - Brown, S J
AU  - Brown SJ
AD  - Department of Dermatology, Ninewells Hospital and Medical School, Dundee, U.K.
FAU - Baryschpolec, S
AU  - Baryschpolec S
AD  - Department of Dermatology, Portsmouth Hospitals NHS Trust, Portsmouth, U.K.
FAU - Darne, S
AU  - Darne S
AD  - Department of Dermatology, South Tees Hospitals NHS Foundation Trust, 
      Middlesbrough, U.K.
FAU - Durack, A
AU  - Durack A
AD  - Department of Dermatology, Addenbrooke's Hospital, Cambridge University Hospitals 
      NHS Foundation Trust, Cambridge, U.K.
FAU - Dvorakova, V
AU  - Dvorakova V
AD  - National Children's Research Centre & Department of Paediatric Dermatology, Our 
      Lady's Children's Hospital, Dublin, Ireland.
FAU - Gach, J
AU  - Gach J
AD  - Department of Dermatology, University Hospitals Coventry and Warwickshire, 
      Coventry, U.K.
FAU - Goldstraw, N
AU  - Goldstraw N
AD  - Department of Dermatology, St George's University Hospitals NHS Foundation Trust, 
      London, U.K.
FAU - Goodyear, H
AU  - Goodyear H
AD  - Department of Paediatric Dermatology, Heart of England NHS Foundation Trust, 
      Birmingham, U.K.
FAU - Grabczynska, S
AU  - Grabczynska S
AD  - Department of Dermatology, Buckinghamshire Healthcare NHS Trust, Amersham, U.K.
FAU - Greenblatt, D
AU  - Greenblatt D
AD  - Department of Dermatology, St George's University Hospitals NHS Foundation Trust, 
      London, U.K.
FAU - Halpern, J
AU  - Halpern J
AD  - Department of Dermatology, Sandwell and West Birmingham Hospitals NHS Trust, 
      Birmingham, U.K.
FAU - Hearn, R M R
AU  - Hearn RM
AD  - Department of Dermatology, Ninewells Hospital and Medical School, Dundee, U.K.
FAU - Hoey, S
AU  - Hoey S
AD  - Department of Dermatology, Royal Victoria Hospital, Belfast, U.K.
FAU - Hughes, B
AU  - Hughes B
AD  - Department of Dermatology, Portsmouth Hospitals NHS Trust, Portsmouth, U.K.
FAU - Jayaraj, R
AU  - Jayaraj R
AD  - Department of Paediatrics, South Tees Hospitals NHS Foundation Trust, 
      Middlesbrough, U.K.
FAU - Johansson, E K
AU  - Johansson EK
AD  - Dermatological and Venereal Clinic, Sodersjukhuset, Stockholm, Sweden.
FAU - Lam, M
AU  - Lam M
AD  - Department of Paediatric Dermatology, Nottingham Children's Hospital, Nottingham, 
      U.K.
FAU - Leech, S
AU  - Leech S
AD  - Department of Paediatric Dermatology, The Newcastle Upon Tyne Hospitals NHS 
      Foundation Trust, Newcastle, U.K.
FAU - O'Regan, G M
AU  - O'Regan GM
AD  - National Children's Research Centre & Department of Paediatric Dermatology, Our 
      Lady's Children's Hospital, Dublin, Ireland.
FAU - Morrison, D
AU  - Morrison D
AD  - Department of Paediatric Ophthalmology, Guy's and St Thomas' Hospitals NHS 
      Foundation Trust, London, U.K.
FAU - Porter, W
AU  - Porter W
AD  - Department of Paediatric Dermatology, Gloucestershire Hospitals NHS Foundation 
      Trust, Gloucester, U.K.
FAU - Ramesh, R
AU  - Ramesh R
AD  - Department of Dermatology, Sandwell and West Birmingham Hospitals NHS Trust, 
      Birmingham, U.K.
FAU - Schill, T
AU  - Schill T
AD  - Departments of Paediatrics & Paediatric Dermatology, Catholic Children's Hospital 
      Wilhelmstift, Hamburg, Germany.
FAU - Shaw, L
AU  - Shaw L
AD  - Department of Paediatric Dermatology, University Hospitals Bristol NHS Foundation 
      Trust, Bristol, U.K.
FAU - Taylor, A E M
AU  - Taylor AE
AD  - Department of Paediatric Dermatology, The Newcastle Upon Tyne Hospitals NHS 
      Foundation Trust, Newcastle, U.K.
FAU - Taylor, R
AU  - Taylor R
AD  - Department of Ophthalmology, York Teaching Hospital NHS Foundation Trust, York, 
      U.K.
FAU - Thomson, J
AU  - Thomson J
AD  - Department of Paediatric Dermatology, St John's Institute of Dermatology, Guy's 
      and St Thomas' Hospitals NHS Foundation Trust, London, U.K.
FAU - Tiffin, P
AU  - Tiffin P
AD  - Department of Ophthalmology, City Hospitals Sunderland NHS Foundation Trust, 
      Sunderland, U.K.
FAU - Tsakok, M
AU  - Tsakok M
AD  - Department of Dermatology, Oxford University Hospitals, Oxford, U.K.
FAU - Janmohamed, S R
AU  - Janmohamed SR
AD  - Department of Dermatology, Universitair Ziekenhuis Brussel, Vrije Universiteit 
      Brussel, Laarbeeklan 101, 1090, Brussels, Belgium.
FAU - Laguda, B
AU  - Laguda B
AD  - Department of Paediatric Dermatology, Chelsea and Westminster Hospital NHS 
      Foundation Trust, London, U.K.
FAU - McPherson, T
AU  - McPherson T
AD  - Department of Dermatology, Oxford University Hospitals, Oxford, U.K.
FAU - Oranje, A P
AU  - Oranje AP
AD  - Department of Dermatology (Paediatric Dermatology and Hair), Dermicis, Alkmaar 
      and Foundation/Network for Pediatric Dermatology Rotterdam, Rotterdam, the 
      Netherlands.
FAU - Patrizi, A
AU  - Patrizi A
AD  - Dermatology Department of Experimental, Diagnostic and Specialty Medicine 
      (DIMES), S. Orsola-Malpighi Hospital, Bologna University, Bologna, Italy.
FAU - Ravenscroft, J C
AU  - Ravenscroft JC
AD  - Department of Paediatric Dermatology, Nottingham Children's Hospital, Nottingham, 
      U.K.
FAU - Shahidullah, H
AU  - Shahidullah H
AD  - Department of Dermatology, Derby NHS Foundation Trust, Derby, U.K.
FAU - Solman, L
AU  - Solman L
AD  - Department of Paediatric Dermatology, Great Ormond Street Hospital NHS Foundation 
      Trust, London, U.K.
FAU - Svensson, A
AU  - Svensson A
AD  - Lund University, Institute of Clinical Research in Malmo, Skane University 
      Hospital, Department of Dermatology, Malmo, Sweden.
FAU - Wahlgren, C F
AU  - Wahlgren CF
AD  - Dermatology Unit, Department of Medicine Solna, Karolinska Institutet and 
      Karolinska University Hospital, Stockholm, Sweden.
FAU - Hoeger, P H
AU  - Hoeger PH
AD  - Departments of Paediatrics & Paediatric Dermatology, Catholic Children's Hospital 
      Wilhelmstift, Hamburg, Germany.
FAU - Flohr, C
AU  - Flohr C
AD  - Department of Paediatric Dermatology, St John's Institute of Dermatology, Guy's 
      and St Thomas' Hospitals NHS Foundation Trust, London, U.K.
LA  - eng
GR  - Department of Health/United Kingdom
PT  - Journal Article
PT  - Multicenter Study
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20151226
PL  - England
TA  - Br J Dermatol
JT  - The British journal of dermatology
JID - 0004041
RN  - 0 (Antineoplastic Agents)
RN  - 9Y8NXQ24VQ (Propranolol)
SB  - IM
MH  - Administration, Oral
MH  - Antineoplastic Agents/*administration & dosage/adverse effects
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Hemangioma/*drug therapy
MH  - Humans
MH  - Infant
MH  - Male
MH  - Propranolol/*administration & dosage/adverse effects
MH  - Skin Neoplasms/*drug therapy
MH  - Treatment Outcome
EDAT- 2015/10/17 06:00
MHDA- 2017/01/04 06:00
CRDT- 2015/10/17 06:00
PHST- 2015/10/05 00:00 [accepted]
PHST- 2015/10/17 06:00 [entrez]
PHST- 2015/10/17 06:00 [pubmed]
PHST- 2017/01/04 06:00 [medline]
AID - 10.1111/bjd.14233 [doi]
PST - ppublish
SO  - Br J Dermatol. 2016 Mar;174(3):594-601. doi: 10.1111/bjd.14233. Epub 2015 Dec 26.