PMID- 26474702
OWN - NLM
STAT- MEDLINE
DCOM- 20160503
LR  - 20181202
IS  - 1090-2104 (Electronic)
IS  - 0006-291X (Linking)
VI  - 467
IP  - 4
DP  - 2015 Nov 27
TI  - Activation of farnesoid X receptor downregulates monocyte chemoattractant 
      protein-1 in murine macrophage.
PG  - 841-6
LID - S0006-291X(15)30755-5 [pii]
LID - 10.1016/j.bbrc.2015.10.056 [doi]
AB  - Farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily, which 
      plays important roles in bile acids/lipid homeostasis and inflammation. Monocyte 
      chemoattractant protein-1 (MCP-1) contributes to macrophage infiltration into 
      body tissues during inflammation. Here we investigated whether FXR can regulate 
      MCP-1 expression in murine macrophage. FXR activation down regulate MCP-1 mRNA 
      and protein levels in ANA-1 and Raw264.7 cells. Luciferase reporter assay, Gel 
      shift and Chromatin immunoprecipitation assays have revealed that the activated 
      FXR bind to the FXR element located in -738 bp  approximately   -723 bp in MCP-1 promoter. 
      These results suggested that FXR may serve as a novel target for regulating MCP-1 
      levels for the inflammation related diseases therapies.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Li, Liangpeng
AU  - Li L
AD  - Department of Biochemistry and Molecular Biology, College of Basic Medical 
      Sciences, Third Military Medical University, 400038, Chongqing, China.
FAU - Zhang, Qian
AU  - Zhang Q
AD  - Department of Biochemistry and Molecular Biology, College of Basic Medical 
      Sciences, Third Military Medical University, 400038, Chongqing, China.
FAU - Peng, Jiahe
AU  - Peng J
AD  - Department of Biochemistry and Molecular Biology, College of Basic Medical 
      Sciences, Third Military Medical University, 400038, Chongqing, China.
FAU - Jiang, Chanjui
AU  - Jiang C
AD  - Department of Biochemistry and Molecular Biology, College of Basic Medical 
      Sciences, Third Military Medical University, 400038, Chongqing, China.
FAU - Zhang, Yan
AU  - Zhang Y
AD  - Department of Biochemistry and Molecular Biology, College of Basic Medical 
      Sciences, Third Military Medical University, 400038, Chongqing, China.
FAU - Shen, Lili
AU  - Shen L
AD  - Department of Biochemistry and Molecular Biology, College of Basic Medical 
      Sciences, Third Military Medical University, 400038, Chongqing, China.
FAU - Dong, Jinyu
AU  - Dong J
AD  - Department of Biochemistry and Molecular Biology, College of Basic Medical 
      Sciences, Third Military Medical University, 400038, Chongqing, China.
FAU - Wang, Yongchao
AU  - Wang Y
AD  - Department of Biochemistry and Molecular Biology, College of Basic Medical 
      Sciences, Third Military Medical University, 400038, Chongqing, China.
FAU - Jiang, Yu
AU  - Jiang Y
AD  - Department of Biochemistry and Molecular Biology, College of Basic Medical 
      Sciences, Third Military Medical University, 400038, Chongqing, China. Electronic 
      address: yujiang0207@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151022
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Ccl2 protein, mouse)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Receptors, Cytoplasmic and Nuclear)
RN  - 0C5V0MRU6P (farnesoid X-activated receptor)
RN  - 0GEI24LG0J (Chenodeoxycholic Acid)
SB  - IM
MH  - Animals
MH  - Binding Sites
MH  - Cell Line/drug effects
MH  - Chemokine CCL2/genetics/*metabolism
MH  - Chenodeoxycholic Acid/pharmacology
MH  - Down-Regulation
MH  - Macrophages/drug effects/*metabolism
MH  - Mice
MH  - Promoter Regions, Genetic
MH  - Receptors, Cytoplasmic and Nuclear/genetics/*metabolism
OTO - NOTNLM
OT  - Bile acids
OT  - Farnesoid X receptor
OT  - Inflammation
OT  - Macrophage
OT  - Monocyte chemoattractant protein-1
EDAT- 2015/10/18 06:00
MHDA- 2016/05/04 06:00
CRDT- 2015/10/18 06:00
PHST- 2015/10/04 00:00 [received]
PHST- 2015/10/10 00:00 [accepted]
PHST- 2015/10/18 06:00 [entrez]
PHST- 2015/10/18 06:00 [pubmed]
PHST- 2016/05/04 06:00 [medline]
AID - S0006-291X(15)30755-5 [pii]
AID - 10.1016/j.bbrc.2015.10.056 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2015 Nov 27;467(4):841-6. doi: 
      10.1016/j.bbrc.2015.10.056. Epub 2015 Oct 22.