PMID- 26475080
OWN - NLM
STAT- MEDLINE
DCOM- 20160916
LR  - 20151028
IS  - 1600-079X (Electronic)
IS  - 0742-3098 (Linking)
VI  - 59
IP  - 4
DP  - 2015 Nov
TI  - Melatonin prevents neural tube defects in the offspring of diabetic pregnancy.
PG  - 508-17
LID - 10.1111/jpi.12282 [doi]
AB  - Melatonin, an endogenous neurohormone secreted by the pineal gland, has a variety 
      of physiological functions and neuroprotective effects. However, its protective 
      role on the neural tube defects (NTDs) was not very clear. The aim of this study 
      was to investigate the effects of melatonin on the incidence of NTDs (including 
      anencephaly, encephalocele, and spina bifida) of offspring from diabetic pregnant 
      mice as well as its underlying mechanisms. Pregnant mice were given 10 mg/kg 
      melatonin by daily i.p. injection from embryonic day (E) 0.5 until being killed 
      on E11.5. Here, we showed that melatonin decreased the NTDs (especially 
      exencephaly) rate of embryos exposed to maternal diabetes. Melatonin stimulated 
      proliferation of neural stem cells (NSCs) under hyperglycemic condition through 
      the extracellular regulated protein kinases (ERK) pathway. Furthermore, as a 
      direct free radical scavenger, melatonin decreased apoptosis of NSCs exposed to 
      hyperglycemia. In the light of these findings, it suggests that melatonin 
      supplementation may play an important role in the prevention of neural 
      malformations in diabetic pregnancy.
CI  - (c) 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Liu, Shangming
AU  - Liu S
AD  - Key Laboratory of the Ministry of Education for Experimental Teratology, 
      Department of Histology and Embryology, Shandong University School of Medicine, 
      Jinan, Shandong, China.
FAU - Guo, Yuji
AU  - Guo Y
AD  - Key Laboratory of the Ministry of Education for Experimental Teratology, 
      Department of Histology and Embryology, Shandong University School of Medicine, 
      Jinan, Shandong, China.
FAU - Yuan, Qiuhuan
AU  - Yuan Q
AD  - Key Laboratory of the Ministry of Education for Experimental Teratology, 
      Department of Histology and Embryology, Shandong University School of Medicine, 
      Jinan, Shandong, China.
FAU - Pan, Yan
AU  - Pan Y
AD  - Institute of Biomedical Engineering, Shandong University School of Medicine, 
      Jinan, Shandong, China.
FAU - Wang, Liyan
AU  - Wang L
AD  - Key Laboratory of the Ministry of Education for Experimental Teratology, 
      Department of Histology and Embryology, Shandong University School of Medicine, 
      Jinan, Shandong, China.
FAU - Liu, Qian
AU  - Liu Q
AD  - Key Laboratory of the Ministry of Education for Experimental Teratology, 
      Department of Histology and Embryology, Shandong University School of Medicine, 
      Jinan, Shandong, China.
FAU - Wang, Fuwu
AU  - Wang F
AD  - Key Laboratory of the Ministry of Education for Experimental Teratology, 
      Department of Histology and Embryology, Shandong University School of Medicine, 
      Jinan, Shandong, China.
FAU - Wang, Jingjing
AU  - Wang J
AD  - Institute of Pathology and Pathophysiology, Shandong University School of 
      Medicine, Jinan, Shandong, China.
FAU - Hao, Aijun
AU  - Hao A
AD  - Key Laboratory of the Ministry of Education for Experimental Teratology, 
      Department of Histology and Embryology, Shandong University School of Medicine, 
      Jinan, Shandong, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151017
PL  - England
TA  - J Pineal Res
JT  - Journal of pineal research
JID - 8504412
RN  - JL5DK93RCL (Melatonin)
SB  - IM
MH  - Animals
MH  - Cell Proliferation/drug effects
MH  - Diabetes Mellitus, Experimental/drug therapy
MH  - Female
MH  - Hyperglycemia/drug therapy
MH  - Melatonin/*therapeutic use
MH  - Mice
MH  - Neural Tube Defects/*drug therapy
MH  - Pregnancy
OTO - NOTNLM
OT  - gestational diabetes mellitus
OT  - hyperglycemia
OT  - melatonin
OT  - neural stem cells
OT  - neural tube defects
EDAT- 2015/10/18 06:00
MHDA- 2016/09/17 06:00
CRDT- 2015/10/18 06:00
PHST- 2015/07/14 00:00 [received]
PHST- 2015/10/02 00:00 [accepted]
PHST- 2015/10/18 06:00 [entrez]
PHST- 2015/10/18 06:00 [pubmed]
PHST- 2016/09/17 06:00 [medline]
AID - 10.1111/jpi.12282 [doi]
PST - ppublish
SO  - J Pineal Res. 2015 Nov;59(4):508-17. doi: 10.1111/jpi.12282. Epub 2015 Oct 17.