PMID- 26476036
OWN - NLM
STAT- MEDLINE
DCOM- 20160915
LR  - 20201216
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Print)
IS  - 0167-5273 (Linking)
VI  - 202
DP  - 2016 Jan 1
TI  - Medical factors that predict quality of life for young adults with congenital 
      heart disease: What matters most?
PG  - 804-9
LID - S0167-5273(15)30557-X [pii]
LID - 10.1016/j.ijcard.2015.09.116 [doi]
AB  - BACKGROUND: Identify demographic and medical status indicators that account for 
      variability in physical and emotional health-related quality of life (QoL) among 
      young adults with congenital heart disease (CHD) as compared to traditional 
      lesion severity categories. METHODS: Cross-sectional study of 218 young adult 
      survivors of CHD (mean=25.7, SD=7.1 years). Participants were recruited from 
      pediatric and adult CHD clinics at a pediatric and an adult hospital. Stepwise 
      linear regression examined the unique contribution of demographic (age; sex; 
      estimated income) and medical status indicators (comorbid conditions; treatment 
      modality; ventricular function/functional capacity) on QoL compared to 
      traditional lesion severity categories (simple; moderate; complex). RESULTS: 
      Lesion severity category accounted for a small portion of the variance in 
      physical QoL (3%), but was not associated with emotional QoL. Lesion severity did 
      not significantly contribute to the variability in physical QoL once other 
      variables were entered. Having an estimated income of </=$30,000, taking more than 
      one cardiac-related medication, and having a New York Heart Association (NYHA) 
      functional class designation>I was associated with poorer physical QoL and 
      explained 23% of the variability. NYHA class was the only variable that explained 
      a unique proportion of variance (7%) in emotional QoL, and having a NYHA class 
      designation>I was associated with greater risk for poorer emotional functioning. 
      CONCLUSIONS: Findings suggested that several indicators readily available to 
      treatment teams may provide important information about the risk for poor 
      patient-reported outcomes of physical and emotional QoL among CHD survivors.
CI  - Copyright (c) 2015 Elsevier Ireland Ltd. All rights reserved.
FAU - Jackson, Jamie L
AU  - Jackson JL
AD  - Center for Biobehavioral Health, Nationwide Children's Hospital, Columbus, OH, 
      United States; Department of Pediatrics, The Ohio State University, Columbus, OH, 
      United States. Electronic address: jamie.jackson2@nationwidechildrens.org.
FAU - Hassen, Lauren
AU  - Hassen L
AD  - College of Medicine, The Ohio State University, Columbus, OH, United States.
FAU - Gerardo, Gina M
AU  - Gerardo GM
AD  - Center for Biobehavioral Health, Nationwide Children's Hospital, Columbus, OH, 
      United States.
FAU - Vannatta, Kathryn
AU  - Vannatta K
AD  - Center for Biobehavioral Health, Nationwide Children's Hospital, Columbus, OH, 
      United States; Department of Pediatrics, The Ohio State University, Columbus, OH, 
      United States.
FAU - Daniels, Curt J
AU  - Daniels CJ
AD  - Columbus Ohio Adult Congenital Heart Disease Program, Heart Center, Nationwide 
      Children's Hospital, Columbus, OH, United States; Departments of Internal 
      Medicine and Pediatrics, The Ohio State University, Columbus, OH, United States.
LA  - eng
GR  - T32 HL098039/HL/NHLBI NIH HHS/United States
GR  - UL1 TR001070/TR/NCATS NIH HHS/United States
GR  - T32 HL-098039/HL/NHLBI NIH HHS/United States
GR  - UL1TR001070/TR/NCATS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20150930
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cross-Sectional Studies
MH  - Female
MH  - Follow-Up Studies
MH  - *Health Status
MH  - Heart Defects, Congenital/*epidemiology/psychology
MH  - Humans
MH  - Male
MH  - Morbidity/trends
MH  - Ohio/epidemiology
MH  - Prognosis
MH  - *Quality of Life
MH  - Retrospective Studies
MH  - Young Adult
PMC - PMC4718071
MID - NIHMS735499
OTO - NOTNLM
OT  - Congenital heart defects
OT  - Quality of life
COIS- Conflict of Interest: None.
EDAT- 2015/10/18 06:00
MHDA- 2016/09/16 06:00
PMCR- 2017/01/01
CRDT- 2015/10/18 06:00
PHST- 2015/04/16 00:00 [received]
PHST- 2015/09/24 00:00 [revised]
PHST- 2015/09/28 00:00 [accepted]
PHST- 2015/10/18 06:00 [entrez]
PHST- 2015/10/18 06:00 [pubmed]
PHST- 2016/09/16 06:00 [medline]
PHST- 2017/01/01 00:00 [pmc-release]
AID - S0167-5273(15)30557-X [pii]
AID - 10.1016/j.ijcard.2015.09.116 [doi]
PST - ppublish
SO  - Int J Cardiol. 2016 Jan 1;202:804-9. doi: 10.1016/j.ijcard.2015.09.116. Epub 2015 
      Sep 30.