PMID- 26476155
OWN - NLM
STAT- MEDLINE
DCOM- 20160720
LR  - 20220316
IS  - 1573-2517 (Electronic)
IS  - 0165-0327 (Linking)
VI  - 190
DP  - 2016 Jan 15
TI  - Risk factors for suicide in bipolar I disorder in two prospectively studied 
      cohorts.
PG  - 1-5
LID - S0165-0327(15)00471-1 [pii]
LID - 10.1016/j.jad.2015.10.007 [doi]
AB  - BACKGROUND: These analyses were undertaken to determine whether similar risk 
      factors for suicide emerged across two prospectively studied cohorts of 
      individuals with bipolar I disorder. METHODS: The NIMH Collaborative Study of 
      Depression (CDS) recruited 288 patients with bipolar I disorder from 1978-1981 as 
      they sought treatment. Subjects were followed semiannually and then annually for 
      up to 30 years. The Bipolar Genomics studies identified individuals through 
      clinical referrals and advertisement. Clinical follow-up did not occur but 
      personal identifiers of 1748 were matched with National Death Index (NDI) 
      records. Kaplan-Meier survival analyses tested ten potential risk factors. 
      RESULTS: The CDS and Genomic follow-ups encompassed 12,667 and 4529 person-years, 
      respectively. Suicides/100 person-years were 0.26 and 0.055. The demographic or 
      clinical variables that predicted suicide differed considerably in the two 
      cohorts. The odds ratio for suicide for those with any history of suicide attempt 
      was 2.3 and 2.8, respectively, and was the third highest odds ratio of the tested 
      risk factors in both studies. CONCLUSIONS: Differences in the sources of 
      participants in studies of suicide risk may result in marked differences across 
      studies in both rates of suicide and in risk factors. A history of suicide 
      attempt is a relatively robust risk factor across samples.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Coryell, William
AU  - Coryell W
AD  - University of Iowa Carver College of Medicine, Department of Psychiatry, United 
      States. Electronic address: william-coryell@uiowa.edu.
FAU - Kriener, Abby
AU  - Kriener A
AD  - University of Iowa Carver College of Medicine, Department of Psychiatry, United 
      States.
FAU - Butcher, Brandon
AU  - Butcher B
AD  - University of Iowa Carver College of Medicine, Department of Psychiatry, United 
      States.
FAU - Nurnberger, John
AU  - Nurnberger J
AD  - Indiana University, Department of Psychiatry, United States.
FAU - McMahon, Francis
AU  - McMahon F
AD  - Johns Hopkins University, Department of Psychiatry, United States.
FAU - Berrettini, Wade
AU  - Berrettini W
AD  - University of Pennsylvania, Department of Psychiatry, United States.
FAU - Fiedorowicz, Jess
AU  - Fiedorowicz J
AD  - University of Iowa Carver College of Medicine, Department of Psychiatry, United 
      States.
LA  - eng
GR  - R01MH025416-33/MH/NIMH NIH HHS/United States
GR  - R01MH059548-09/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20151013
PL  - Netherlands
TA  - J Affect Disord
JT  - Journal of affective disorders
JID - 7906073
SB  - IM
MH  - Adult
MH  - Bipolar Disorder/*mortality
MH  - Female
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Prospective Studies
MH  - Risk Factors
MH  - Suicide/*statistics & numerical data
MH  - Suicide, Attempted/statistics & numerical data
MH  - Young Adult
OTO - NOTNLM
OT  - Bipolar disorder
OT  - Risk factors
OT  - Suicide
OT  - Suicide attempts
EDAT- 2015/10/18 06:00
MHDA- 2016/07/21 06:00
CRDT- 2015/10/18 06:00
PHST- 2014/08/21 00:00 [received]
PHST- 2015/03/25 00:00 [revised]
PHST- 2015/10/02 00:00 [accepted]
PHST- 2015/10/18 06:00 [entrez]
PHST- 2015/10/18 06:00 [pubmed]
PHST- 2016/07/21 06:00 [medline]
AID - S0165-0327(15)00471-1 [pii]
AID - 10.1016/j.jad.2015.10.007 [doi]
PST - ppublish
SO  - J Affect Disord. 2016 Jan 15;190:1-5. doi: 10.1016/j.jad.2015.10.007. Epub 2015 
      Oct 13.