PMID- 26476211
OWN - NLM
STAT- MEDLINE
DCOM- 20160419
LR  - 20220408
IS  - 1879-1891 (Electronic)
IS  - 0002-9394 (Linking)
VI  - 161
DP  - 2016 Jan
TI  - Optical Coherence Tomography Angiography in Retinal Vein Occlusion: Evaluation of 
      Superficial and Deep Capillary Plexa.
PG  - 160-71.e1-2
LID - S0002-9394(15)00636-4 [pii]
LID - 10.1016/j.ajo.2015.10.008 [doi]
AB  - PURPOSE: To evaluate the optical coherence tomography angiography (OCT 
      angiography) appearance of the superficial and deep capillary plexa in eyes with 
      retinal vein occlusion (RVO) and to compare these findings with those of 
      fluorescein angiography (FA) and spectral-domain optical coherence tomography (SD 
      OCT). DESIGN: Retrospective observational case series. METHODS: Patients 
      presenting with RVO to Creteil University Eye Clinic were retrospectively 
      evaluated. All patients had undergone a comprehensive ophthalmic examination 
      including FA, SD OCT, and OCT angiography. RESULTS: There were 54 (31 male, 57%) 
      RVO patients with a mean age of 70 years. The perifoveal capillary arcade was 
      visible in 52 of 54 eyes (96%) on OCT angiography and in 45 eyes (83%) on FA; 
      this arcade was disrupted in 48 eyes (92%) and 39 eyes (72%) on OCT angiography 
      and FA, respectively (P = .002). Perifoveal capillary arcade disruption was 
      correlated with peripheral retinal ischemia (P = .025). Intraretinal cystoid 
      spaces were observed in 34 eyes (68%) using FA, in 40 eyes (76%) using SD OCT, 
      and in 49 eyes (90%) using OCT angiography (P = .008 for OCT angiography vs SD 
      OCT and P = .001 for OCT angiography vs FA). Retinal capillary network 
      abnormalities were observed in all patients in both superficial capillary plexus 
      and deep capillary plexus on OCT angiography. Nonperfusion grayish areas were 
      more frequent in the deep capillary plexus (43 eyes, 84%) than in the superficial 
      capillary plexus (30 eyes, 59%, P < .001). CONCLUSION: OCT angiography can 
      simultaneously evaluate both macular perfusion and edema. For the first time, an 
      imaging technique enables the evaluation of the deep capillary plexus, which 
      appears to be more severely affected than the superficial capillary plexus in 
      RVO.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Coscas, Florence
AU  - Coscas F
AD  - Department of Ophthalmology, Centre Hospitalier Intercommunal de Creteil, 
      Universite Paris Est, Creteil, France; Centre Ophtalmologique de l'Odeon, Paris, 
      France. Electronic address: coscas.f@gmail.com.
FAU - Glacet-Bernard, Agnes
AU  - Glacet-Bernard A
AD  - Department of Ophthalmology, Centre Hospitalier Intercommunal de Creteil, 
      Universite Paris Est, Creteil, France.
FAU - Miere, Alexandra
AU  - Miere A
AD  - Department of Ophthalmology, Centre Hospitalier Intercommunal de Creteil, 
      Universite Paris Est, Creteil, France.
FAU - Caillaux, Violaine
AU  - Caillaux V
AD  - Department of Ophthalmology, Centre Hospitalier Intercommunal de Creteil, 
      Universite Paris Est, Creteil, France.
FAU - Uzzan, Joel
AU  - Uzzan J
AD  - Department of Ophthalmology, Centre Hospitalier Intercommunal de Creteil, 
      Universite Paris Est, Creteil, France.
FAU - Lupidi, Marco
AU  - Lupidi M
AD  - Centre Ophtalmologique de l'Odeon, Paris, France.
FAU - Coscas, Gabriel
AU  - Coscas G
AD  - Department of Ophthalmology, Centre Hospitalier Intercommunal de Creteil, 
      Universite Paris Est, Creteil, France; Centre Ophtalmologique de l'Odeon, Paris, 
      France.
FAU - Souied, Eric H
AU  - Souied EH
AD  - Department of Ophthalmology, Centre Hospitalier Intercommunal de Creteil, 
      Universite Paris Est, Creteil, France.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20151023
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Capillaries
MH  - Female
MH  - *Fluorescein Angiography
MH  - Humans
MH  - Ischemia/*diagnosis
MH  - Laser Coagulation
MH  - Macular Edema/*diagnosis
MH  - Male
MH  - Middle Aged
MH  - Retinal Vein Occlusion/*diagnosis/surgery
MH  - Retinal Vessels/*pathology
MH  - Retrospective Studies
MH  - *Tomography, Optical Coherence
MH  - Visual Acuity/physiology
EDAT- 2015/10/18 06:00
MHDA- 2016/04/20 06:00
CRDT- 2015/10/18 06:00
PHST- 2015/07/21 00:00 [received]
PHST- 2015/10/04 00:00 [revised]
PHST- 2015/10/06 00:00 [accepted]
PHST- 2015/10/18 06:00 [entrez]
PHST- 2015/10/18 06:00 [pubmed]
PHST- 2016/04/20 06:00 [medline]
AID - S0002-9394(15)00636-4 [pii]
AID - 10.1016/j.ajo.2015.10.008 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2016 Jan;161:160-71.e1-2. doi: 10.1016/j.ajo.2015.10.008. Epub 
      2015 Oct 23.