PMID- 26476398 OWN - NLM STAT- MEDLINE DCOM- 20161019 LR - 20181113 IS - 2047-2412 (Electronic) IS - 2047-2404 (Print) IS - 2047-2404 (Linking) VI - 17 IP - 2 DP - 2016 Feb TI - Incremental value of quantitative CMR including parametric mapping for the diagnosis of acute myocarditis. PG - 154-61 LID - 10.1093/ehjci/jev246 [doi] AB - AIM: Cardiac magnetic resonance (CMR) can visualize inflammatory tissue changes in acute myocarditis. Several quantitative image-derived parameters have been described to enhance the diagnostic value of CMR, but no direct comparison of these techniques is available. METHODS AND RESULTS: A total of 34 patients with suspected acute myocarditis and 50 control subjects underwent CMR. CMR protocol included quantitative assessment of T1 relaxation times using modified Look-Locker inversion recovery (MOLLI) and shortened MOLLI (ShMOLLI) acquisition schemes, extracellular volume fraction (ECV), T2 relaxation times, and longitudinal strain. Established Lake-Louise criteria (LLC) consisting of T2-weighted signal intensity ratio (T2-ratio), early gadolinium enhancement ratio (EGEr), and late gadolinium enhancement (LGE) were assessed. Receiver operating characteristics analysis was performed to compare diagnostic performance. Areas under the curve of native T1 (MOLLI: 0.95; ShMOLLI: 0.92) and T2 relaxation times (0.92) were higher compared with those of the other CMR parameters (T2-ratio: 0.71, EGEr: 0.71, LGE: 0.87, LLC: 0.90, ECV MOLLI: 0.77, ECV ShMOLLI: 0.80, longitudinal strain: 0.83). Combined with LGE, each native mapping technique outperformed the diagnostic performance of LLC (P < 0.01, respectively). A combination of native parameters (T1, T2, and longitudinal strain) significantly increased the diagnostic performance of CMR compared with LLC without need of contrast media application (0.99 vs. 0.90; P = 0.008). CONCLUSION: In patients suspected of having acute myocarditis, diagnostic performance of CMR can be improved by implementation of quantitative CMR parameters. Especially, native mapping techniques have the potential to replace current LLC. CLINICALTRIALS. GOV NUMBER: NCT02299856. CI - Published on behalf of the European Society of Cardiology. All rights reserved. (c) The Author 2015. For permissions please email: journals.permissions@oup.com. FAU - Luetkens, Julian A AU - Luetkens JA AD - Department of Radiology, University of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany. FAU - Homsi, Rami AU - Homsi R AD - Department of Radiology, University of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany. FAU - Sprinkart, Alois M AU - Sprinkart AM AD - Department of Radiology, University of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany. FAU - Doerner, Jonas AU - Doerner J AD - Department of Radiology, University of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany Department of Radiology, University Hospital Cologne, Kerpener Str. 62, 50937 Cologne, Germany. FAU - Dabir, Darius AU - Dabir D AD - Department of Radiology, University of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany. FAU - Kuetting, Daniel L AU - Kuetting DL AD - Department of Radiology, University of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany. FAU - Block, Wolfgang AU - Block W AD - Department of Radiology, University of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany. FAU - Andrie, Rene AU - Andrie R AD - Department of Cardiology, University of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany. FAU - Stehning, Christian AU - Stehning C AD - Philips Research, Hamburg, Germany. FAU - Fimmers, Rolf AU - Fimmers R AD - Department of Medical Biometry, Informatics, and Epidemiology, University of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany. FAU - Gieseke, Juergen AU - Gieseke J AD - Department of Radiology, University of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany Philips Research, Hamburg, Germany. FAU - Thomas, Daniel K AU - Thomas DK AD - Department of Radiology, University of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany. FAU - Schild, Hans H AU - Schild HH AD - Department of Radiology, University of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany. FAU - Naehle, Claas P AU - Naehle CP AD - Department of Radiology, University of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany cp@naehle.net. LA - eng SI - ClinicalTrials.gov/NCT02299856 PT - Journal Article DEP - 20151016 PL - England TA - Eur Heart J Cardiovasc Imaging JT - European heart journal. Cardiovascular Imaging JID - 101573788 RN - 0 (Biomarkers) RN - 0 (Contrast Media) RN - 0 (Organometallic Compounds) RN - 1BJ477IO2L (gadobutrol) SB - IM CIN - Eur Heart J Cardiovasc Imaging. 2016 Feb;17(2):134-5. PMID: 26590400 MH - Acute Disease MH - Adult MH - Biomarkers/blood MH - Cardiac-Gated Imaging Techniques MH - Case-Control Studies MH - Contrast Media MH - Diagnosis, Differential MH - Electrocardiography MH - Female MH - Humans MH - Image Interpretation, Computer-Assisted MH - Magnetic Resonance Imaging/*methods MH - Male MH - Middle Aged MH - Myocarditis/*diagnosis/pathology MH - Organometallic Compounds MH - Prospective Studies PMC - PMC4882886 OTO - NOTNLM OT - Diagnosis OT - Inflammation OT - Magnetic resonance imaging OT - Mapping OT - Myocarditis EDAT- 2015/10/18 06:00 MHDA- 2016/12/07 06:00 PMCR- 2017/02/01 CRDT- 2015/10/18 06:00 PHST- 2015/04/29 00:00 [received] PHST- 2015/09/14 00:00 [accepted] PHST- 2015/10/18 06:00 [entrez] PHST- 2015/10/18 06:00 [pubmed] PHST- 2016/12/07 06:00 [medline] PHST- 2017/02/01 00:00 [pmc-release] AID - jev246 [pii] AID - 10.1093/ehjci/jev246 [doi] PST - ppublish SO - Eur Heart J Cardiovasc Imaging. 2016 Feb;17(2):154-61. doi: 10.1093/ehjci/jev246. Epub 2015 Oct 16.