PMID- 26478340
OWN - NLM
STAT- MEDLINE
DCOM- 20160801
LR  - 20220331
IS  - 1873-0191 (Electronic)
IS  - 0928-4931 (Linking)
VI  - 58
DP  - 2016 Jan 1
TI  - Electrospinning of PLGA/gum tragacanth nanofibers containing tetracycline 
      hydrochloride for periodontal regeneration.
PG  - 521-31
LID - S0928-4931(15)30322-2 [pii]
LID - 10.1016/j.msec.2015.08.066 [doi]
AB  - Controlled drug release is a process in which a predetermined amount of drug is 
      released for longer period of time, ranging from days to months, in a controlled 
      manner. In this study, novel drug delivery devices were fabricated via blend 
      electrospinning and coaxial electrospinning using poly lactic glycolic acid 
      (PLGA), gum tragacanth (GT) and tetracycline hydrochloride (TCH) as a hydrophilic 
      model drug in different compositions and their performance as a drug carrier 
      scaffold was evaluated. Scanning electron microscopy (SEM) results showed that 
      fabricated PLGA, blend PLGA/GT and core shell PLGA/GT nanofibers had a smooth and 
      bead-less morphology with the diameter ranging from 180 to 460 nm. Drug release 
      studies showed that both the fraction of GT within blend nanofibers and the 
      core-shell structure can effectively control TCH release rate from the 
      nanofibrous membranes. By incorporation of TCH into core-shell nanofibers, drug 
      release was sustained for 75 days with only 19% of burst release within the first 
      2h. The prolonged drug release, together with proven biocompatibility, 
      antibacterial and mechanical properties of drug loaded core shell nanofibers make 
      them a promising candidate to be used as drug delivery system for periodontal 
      diseases.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Ranjbar-Mohammadi, Marziyeh
AU  - Ranjbar-Mohammadi M
AD  - Textile Engineering Group, Department of Engineering, University of Bonab, Bonab, 
      Iran.
FAU - Zamani, M
AU  - Zamani M
AD  - Mechanical Engineering Department, National University of Singapore, Singapore; 
      Nanoscience and Nanotechnology Initiative, Faculty of Engineering, National 
      University of Singapore, Singapore.
FAU - Prabhakaran, M P
AU  - Prabhakaran MP
AD  - Nanoscience and Nanotechnology Initiative, Faculty of Engineering, National 
      University of Singapore, Singapore. Electronic address: nnimpp@nus.edu.sg.
FAU - Bahrami, S Hajir
AU  - Bahrami SH
AD  - Textile Engineering Department, Amirkabir University of Technology, Tehran, Iran. 
      Electronic address: hajirb@aut.ac.ir.
FAU - Ramakrishna, S
AU  - Ramakrishna S
AD  - Mechanical Engineering Department, National University of Singapore, Singapore; 
      Nanoscience and Nanotechnology Initiative, Faculty of Engineering, National 
      University of Singapore, Singapore.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150903
PL  - Netherlands
TA  - Mater Sci Eng C Mater Biol Appl
JT  - Materials science & engineering. C, Materials for biological applications
JID - 101484109
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Drug Carriers)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - 33X04XA5AT (Lactic Acid)
RN  - 9000-65-1 (Tragacanth)
RN  - F8VB5M810T (Tetracycline)
SB  - IM
MH  - Anti-Bacterial Agents/*chemistry/pharmacology
MH  - Bacteria/drug effects
MH  - Cell Proliferation
MH  - Cells, Cultured
MH  - Drug Carriers/chemistry
MH  - Electrochemical Techniques/*methods
MH  - Fibroblasts
MH  - Humans
MH  - Lactic Acid/*chemistry
MH  - Nanofibers/*chemistry
MH  - Nanotechnology
MH  - Particle Size
MH  - Periodontitis
MH  - Polyglycolic Acid/*chemistry
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
MH  - Porosity
MH  - Tetracycline/*chemistry/pharmacology
MH  - Tissue Engineering
MH  - Tissue Scaffolds/*chemistry
MH  - Tragacanth/*chemistry
OTO - NOTNLM
OT  - Coaxial electrospinning
OT  - Electrospun nanofibers
OT  - Gum tragacanth
OT  - PLGA
OT  - Periodontal regeneration
EDAT- 2015/10/20 06:00
MHDA- 2016/08/02 06:00
CRDT- 2015/10/20 06:00
PHST- 2015/05/14 00:00 [received]
PHST- 2015/08/23 00:00 [revised]
PHST- 2015/08/27 00:00 [accepted]
PHST- 2015/10/20 06:00 [entrez]
PHST- 2015/10/20 06:00 [pubmed]
PHST- 2016/08/02 06:00 [medline]
AID - S0928-4931(15)30322-2 [pii]
AID - 10.1016/j.msec.2015.08.066 [doi]
PST - ppublish
SO  - Mater Sci Eng C Mater Biol Appl. 2016 Jan 1;58:521-31. doi: 
      10.1016/j.msec.2015.08.066. Epub 2015 Sep 3.