PMID- 26479580
OWN - NLM
STAT- MEDLINE
DCOM- 20160929
LR  - 20220331
IS  - 1360-0451 (Electronic)
IS  - 0954-0121 (Print)
IS  - 0954-0121 (Linking)
VI  - 28
IP  - 4
DP  - 2016
TI  - Coronary artery disease risk reduction in HIV-infected persons: a comparative 
      analysis.
PG  - 475-82
LID - 10.1080/09540121.2015.1099602 [doi]
AB  - Despite an increased risk of coronary artery disease (CAD) in persons infected 
      with human immunodeficiency virus (HIV), few data are available on primary 
      prevention of CAD in this population. In this retrospective cohort study, 
      HIV-infected patients treated in an academic medical center HIV Specialty Clinic 
      between 1996 and 2010 were matched by age, gender, and ethnicity to a cohort of 
      presumed uninfected persons followed in an academic medical center Internal 
      Medicine primary care clinic. We compared CAD primary prevention care practices 
      between the two clinics, including use of aspirin, HMG-CoA reductase inhibitors 
      ("statins"), and anti-hypertensive drugs. CAD risk between the two groups was 
      assessed with 10-year Framingham CAD risk scores. In the comparative analysis, 
      890 HIV-infected persons were compared to 807 controls. Ten-year Framingham CAD 
      Risk Scores were similar in the two groups (median, 3; interquartile range [IQR], 
      0-5). After adjusting for relevant risk factors, HIV-infected persons were less 
      likely to be prescribed aspirin (odds ratio [OR] 0.53; 95% confidence interval 
      [CI], 0.40-0.71), statins (OR, 0.70; 95% CI, 0.53-0.92), and anti-hypertensive 
      drugs (OR, 0.63; 95% CI, 0.50-0.79) than persons in the control group. In 
      summary, when compared to demographically similar uninfected persons, 
      HIV-infected persons treated in an HIV specialty clinic were less likely to be 
      prescribed medications appropriate for CAD risk reduction. Improving primary 
      preventative CAD care in HIV specialty clinic populations is an important step 
      toward diminishing risk of heart disease in HIV-infected persons.
FAU - Okeke, Nwora Lance
AU  - Okeke NL
AD  - a Division of Infectious Diseases, Department of Medicine , Duke University 
      Medical Center , Durham , NC , USA.
FAU - Chin, Tammy
AU  - Chin T
AD  - b School of Medicine , The University of North Carolina , Chapel Hill , NC , USA.
FAU - Clement, Meredith
AU  - Clement M
AD  - a Division of Infectious Diseases, Department of Medicine , Duke University 
      Medical Center , Durham , NC , USA.
FAU - Chow, Shein-Chung
AU  - Chow SC
AD  - c Department of Biostatistics and Bioinformatics , Duke University School of 
      Medicine , Durham , NC , USA.
FAU - Hicks, Charles B
AU  - Hicks CB
AD  - d Division of Infectious Diseases, Department of Medicine , University of 
      California , San Diego , CA , USA.
LA  - eng
GR  - P30 AI064518/AI/NIAID NIH HHS/United States
GR  - T32 AI007392/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20151019
PL  - England
TA  - AIDS Care
JT  - AIDS care
JID - 8915313
RN  - R16CO5Y76E (Aspirin)
SB  - IM
MH  - Adult
MH  - Aspirin/administration & dosage/*therapeutic use
MH  - Case-Control Studies
MH  - Coronary Artery Disease/*prevention & control
MH  - Drug Prescriptions/*statistics & numerical data
MH  - Female
MH  - HIV Infections/*complications/epidemiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - *Practice Patterns, Physicians'
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Risk Reduction Behavior
PMC - PMC4784685
MID - NIHMS732665
OTO - NOTNLM
OT  - HIV
OT  - cardiovascular disease
OT  - clinical outcomes research
OT  - coronary artery disease
OT  - primary care
EDAT- 2015/10/20 06:00
MHDA- 2016/09/30 06:00
PMCR- 2016/04/01
CRDT- 2015/10/20 06:00
PHST- 2015/10/20 06:00 [entrez]
PHST- 2015/10/20 06:00 [pubmed]
PHST- 2016/09/30 06:00 [medline]
PHST- 2016/04/01 00:00 [pmc-release]
AID - 10.1080/09540121.2015.1099602 [doi]
PST - ppublish
SO  - AIDS Care. 2016;28(4):475-82. doi: 10.1080/09540121.2015.1099602. Epub 2015 Oct 
      19.