PMID- 26480462
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160114
LR  - 20181023
IS  - 1094-4087 (Electronic)
IS  - 1094-4087 (Linking)
VI  - 23
IP  - 21
DP  - 2015 Oct 19
TI  - Spectral-domain optical coherence tomography with dual-balanced detection for 
      auto-correlation artifacts reduction.
PG  - 28050-8
LID - 10.1364/OE.23.028050 [doi]
AB  - We developed a spectral domain optical coherence tomography (SD-OCT) to reduce 
      auto-correlation artifacts (AC) using dual-balanced detection (DBD). AC were 
      composed of the interference signals between different sample tissue depths, and 
      shown up as artifacts in OCT images. This system employed a free-space Michelson 
      interferometer, at the refraction plane of whose beam splitter, the light 
      reflected experienced a pi/2 phase shift with respect to the light transmitted. 
      Then two phase-opposed interferometric spectra sharing the same spectrometer 
      optics were obtained simultaneously using two lines of a three-line CCD. This new 
      design was of lower cost compared to the dual spectrometer design reported 
      previously. DBD enabled this SD-OCT to achieve two-fold increase in the 
      interested signal amplitude inherently, and obtain a SNR increase of ~2.9 dB 
      experimentally. To demonstrate the feasibility and performance of this SD-OCT 
      system with DBD, we conducted an imaging experiment using a glass plate to obtain 
      the optimal spectral matching between dual-balanced spectrometer channels. As a 
      result, this SD-OCT achieved AC reduction up to about 9 dB and direct current 
      (DC) term suppression up to about 30 dB by cancelling the identical components 
      between dual-balanced spectrometer channels. The efficacy of AC reduction and DC 
      suppression was validated by imaging the polymer coating of a drug-eluting stent 
      and fresh swine corneal tissue ex vivo. The quality of DBD optimized images was 
      significantly improved with regard to the single-channel images.
FAU - Bo, En
AU  - Bo E
FAU - Liu, Xinyu
AU  - Liu X
FAU - Chen, Si
AU  - Chen S
FAU - Yu, Xiaojun
AU  - Yu X
FAU - Wang, Xianghong
AU  - Wang X
FAU - Liu, Linbo
AU  - Liu L
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Opt Express
JT  - Optics express
JID - 101137103
EDAT- 2015/10/21 06:00
MHDA- 2015/10/21 06:01
CRDT- 2015/10/20 06:00
PHST- 2015/10/20 06:00 [entrez]
PHST- 2015/10/21 06:00 [pubmed]
PHST- 2015/10/21 06:01 [medline]
AID - 331345 [pii]
AID - 10.1364/OE.23.028050 [doi]
PST - ppublish
SO  - Opt Express. 2015 Oct 19;23(21):28050-8. doi: 10.1364/OE.23.028050.