PMID- 26480548
OWN - NLM
STAT- MEDLINE
DCOM- 20151112
LR  - 20151020
IS  - 0255-2930 (Print)
IS  - 0255-2930 (Linking)
VI  - 35
IP  - 6
DP  - 2015 Jun
TI  - [Expressions of neurotransmitters in patients of insomnia differentiated as liver 
      stagnation transforming into fire treated with acupuncture].
PG  - 549-52
AB  - OBJECTIVE: To compare the difference in the efficacy between acupuncture and oral 
      administration of trazodone and the expressions of neurotransmitters in patients 
      of insomnia differentiated as liver stagnation transforming into fire. METHODS: 
      Seventy patients of insomnia differentiated as liver stagnation transforming into 
      fire were randomized into an observation group and a control group, 35 cases in 
      each one. In the observation group, acupuncture therapy was adopted at Shenmen 
      (HT 7), Baihui (GV 20), Yintang (GV 29), Hegu (LI 4), Taichong (LR 3), etc. The 
      needles were retained for 20 min each time. The treatment was given once a day, 
      the treatment of 2 weeks made one session. In the control group, trazodone, 100 
      mg, oral administration, once a day, the treatment of 2 weeks made one session. 
      Two sessions were required in the two groups. The scores in Pittsburgh sleep 
      quality index (PSQI) and Asberg rating scale for side effects (SERS), the levels 
      of neurotransmitters such as 5-hydroxy tryptamine (5-HT) and norepinephrine (NE) 
      and the expressions of protein kinase C (PKC) and brain-derived neurotrophic 
      factor (BDNF) in peripheral blood were observed before and after treatment in the 
      two groups. RESULTS: PSQI score and SERS score after treatment were all decreased 
      compared with those in both groups before treatment (both P<0. 05). After 
      treatment, PSQI score and SERS score in the observation group were lower 
      apparently than those in the control group (both P<0. 05). After treatment NE 
      content and PKC level were decreased; 5-HT content and BDNF mRNA were increased 
      compared with those in both groups before treatment (all P<0. 05). NE content and 
      PKC level in the observation group were lower apparently than those in the 
      control group (both P<0. 05). The serum 5-HT content and BDNF mRNA expression in 
      the observation group were higher than those in the control group separately 
      (both P<0. 05). CONCLUSION: Acupuncture therapy improves the sleeping quality of 
      patients of insomnia differentiated as liver stagnation transforming into fire, 
      and reduces serum NE level and increases 5-HT content and BDNF expression, which 
      achieves the better efficacy as compared with the oral administration of 
      trazodone. It is one of the effective approaches to the treatment of insomnia 
      differentiated as liver stagnation transforming into fire.
FAU - Ji, Xiangdong
AU  - Ji X
FAU - Wang, Qunsong
AU  - Wang Q
FAU - Zhu, Wenxian
AU  - Zhu W
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhongguo Zhen Jiu
JT  - Zhongguo zhen jiu = Chinese acupuncture & moxibustion
JID - 8600658
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Neurotransmitter Agents)
RN  - 333DO1RDJY (Serotonin)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Acupuncture Points
MH  - *Acupuncture Therapy
MH  - Adult
MH  - Aged
MH  - Brain-Derived Neurotrophic Factor/genetics/metabolism
MH  - Female
MH  - Humans
MH  - Liver/physiopathology
MH  - Male
MH  - Neurotransmitter Agents/*genetics/metabolism
MH  - Norepinephrine/genetics/metabolism
MH  - Serotonin/metabolism
MH  - Sleep Initiation and Maintenance 
      Disorders/genetics/metabolism/physiopathology/*therapy
MH  - Treatment Outcome
EDAT- 2015/10/21 06:00
MHDA- 2015/11/13 06:00
CRDT- 2015/10/21 06:00
PHST- 2015/10/21 06:00 [entrez]
PHST- 2015/10/21 06:00 [pubmed]
PHST- 2015/11/13 06:00 [medline]
PST - ppublish
SO  - Zhongguo Zhen Jiu. 2015 Jun;35(6):549-52.