PMID- 26480560
OWN - NLM
STAT- MEDLINE
DCOM- 20151112
LR  - 20181202
IS  - 0255-2930 (Print)
IS  - 0255-2930 (Linking)
VI  - 35
IP  - 6
DP  - 2015 Jun
TI  - [Neurological protection effects of "paraplegia-triple-needling method" on rats 
      with incomplete spinal cord injury].
PG  - 585-9
AB  - OBJECTIVE: To observe the neurological protection effects of 
      "paraplegia-triple-needling method" on rats with incomplete spinal cord injury 
      (SCI), so as to make a preliminary exploration on its mechanism. METHODS: A total 
      of 45 SD rats were randomly divided into a paraplegia-triple-needling method 
      group (group A), a regular acupuncture group (group B) and a model group (group 
      C), 15 rats in each one. The rats model of incomplete spinal cord injury was 
      established by modified Allen's method. The acupoints of governor vessel and 
      back-shu points next to the vertebras of upper end and lower end of injured 
      segment as well as motor points in key muscle of lower extremities were treated 
      with acupuncture in the group A; the acupoints of governor vessel and back-shu 
      points next to the vertebras of upper end and lower end of injured segment as 
      well as "Huantiao" (GB 30), "Housanli" (ST 36), "Yanglingquan" (GB 34) and 
      "Genduan"(Extra) were treated with acupuncture in the group B; rats in the group 
      C received no treatment after model establishment but grabbing and 
      immobilization. The needles were retained for 15 min in the group A and group B, 
      once a day for 14 times. 1 d, 7 d and 14 d after model establishment, Basso 
      Beattie Bresnahan (BBB) scores were observed in each group; the morphologic 
      change of injured spinal cord and expression of positive cells of calcitonin 
      gene-related peptide (CGRP) were observed. Results (1) One day after SCI, there 
      was no significant difference of BBB scores among three groups (P> 0. 05); 7 days 
      and 14 days after SCI, BBB scores in the group A and group B were significantly 
      superior to those in the group C (all P<0. 05), and the BBB scores in the group A 
      were superior to those in the group B ( both P<0. 05). (2) There was expression 
      of CGRP positive cells in all three groups, and that in the group A and group B 
      was significantly higher than that in group C (both P<0. 05); 14 days after 
      treatment, the expression in the group A was higher than that in the group B 
      (P<0. 05). CONCLUSION: The "paraplegia-triple-needling method" could obviously! 
      improve the motor function of rats with SCI, especially the expression of 
      neuroprotective factor CGRP, which is likely to be one of the mechanisms of 
      neurological protection effect.
FAU - Ke, Xiaohua
AU  - Ke X
FAU - Wang, Yu
AU  - Wang Y
FAU - Zhang, Anren
AU  - Zhang A
FAU - Jiang, Yue
AU  - Jiang Y
FAU - Dong, Chao
AU  - Dong C
FAU - Wang, Qian
AU  - Wang Q
FAU - Zhang, Shanshan
AU  - Zhang S
FAU - Chen, Shasha
AU  - Chen S
FAU - Huang, Binyang
AU  - Huang B
FAU - Gong, Sihui
AU  - Gong S
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhongguo Zhen Jiu
JT  - Zhongguo zhen jiu = Chinese acupuncture & moxibustion
JID - 8600658
RN  - JHB2QIZ69Z (Calcitonin Gene-Related Peptide)
SB  - IM
MH  - Acupuncture Points
MH  - *Acupuncture Therapy/instrumentation/methods
MH  - Animals
MH  - Calcitonin Gene-Related Peptide/genetics/metabolism
MH  - Disease Models, Animal
MH  - Humans
MH  - Male
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Spinal Cord Injuries/genetics/metabolism/*therapy
EDAT- 2015/10/21 06:00
MHDA- 2015/11/13 06:00
CRDT- 2015/10/21 06:00
PHST- 2015/10/21 06:00 [entrez]
PHST- 2015/10/21 06:00 [pubmed]
PHST- 2015/11/13 06:00 [medline]
PST - ppublish
SO  - Zhongguo Zhen Jiu. 2015 Jun;35(6):585-9.