PMID- 26481453
OWN - NLM
STAT- MEDLINE
DCOM- 20170719
LR  - 20210703
IS  - 1742-481X (Electronic)
IS  - 1742-4801 (Print)
IS  - 1742-4801 (Linking)
VI  - 13
IP  - 6
DP  - 2016 Dec
TI  - Allogeneic hand transplantation and rehabilitation of hand function: a 10-year 
      follow-up study.
PG  - 1303-1308
LID - 10.1111/iwj.12520 [doi]
AB  - The purpose of this study is to present the long-term outcomes of allogenic hand 
      transplantations performed at our centre. Between January 2001 and October 2002, 
      five allogeneic limb transplantations were performed in three patients (two 
      bilateral forearm and one left hand transplantation). Donors and recipients were 
      matched for blood types (ABO/Rh) and had at least two human leukocyte antigen 
      (HLA) matches. A comprehensive rehabilitation plan integrating preoperative, 
      intraoperative and postoperative management was developed for each patient. After 
      10 years, all transplantations were performed successfully without complications. 
      As of 2014, all grafts were viable. The transplanted hands showed palmate 
      morphology, perceived superficial pain and tactile sensations, and the static 
      two-point discrimination ranged from 2.5 to 4.0 mm. Chronic rejection at 4 years 
      after surgery reduced hand function in case 2. Grip strength ranged from 3 kg 
      (case 2) to 16-18 kg (case 1) to 41-43 kg for case 3. Lifting strength ranged 
      from 3 kg (case 2) to 21-23 kg (case 1) to 47-51 kg for case 3. They lead a 
      completely independent life. In summary, hand function following allogeneic limb 
      transplantation allows the ability to perform tasks of daily living.
CI  - (c) 2015 Medicalhelplines.com Inc and John Wiley & Sons Ltd.
FAU - Zhang, Zhen-Yu
AU  - Zhang ZY
AD  - Department of Orthopaedics, The First Affiliated Hospital of Harbin Medical 
      University, Harbin, China.
FAU - Li, Fu-Chun
AU  - Li FC
AD  - Department of Orthopaedics, The First Affiliated Hospital of Harbin Medical 
      University, Harbin, China.
FAU - Shao, Ming
AU  - Shao M
AD  - Department of Orthopaedics, The First Affiliated Hospital of Harbin Medical 
      University, Harbin, China.
FAU - Yang, Cao
AU  - Yang C
AD  - Department of Orthopaedics, The First Affiliated Hospital of Harbin Medical 
      University, Harbin, China.
FAU - Shang, Jian
AU  - Shang J
AD  - Department of Orthopaedics, The First Affiliated Hospital of Harbin Medical 
      University, Harbin, China.
FAU - Bi, Zheng-Gang
AU  - Bi ZG
AD  - Department of Orthopaedics, The First Affiliated Hospital of Harbin Medical 
      University, Harbin, China.
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20151020
PL  - England
TA  - Int Wound J
JT  - International wound journal
JID - 101230907
RN  - 0 (Immunosuppressive Agents)
SB  - IM
MH  - Adult
MH  - Follow-Up Studies
MH  - Graft Rejection
MH  - Graft Survival
MH  - Hand Strength/*physiology
MH  - Hand Transplantation/adverse effects/*methods/rehabilitation
MH  - Humans
MH  - Immunosuppressive Agents/therapeutic use
MH  - Male
MH  - Middle Aged
MH  - Postoperative Care/methods
MH  - *Quality of Life
MH  - *Recovery of Function
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Sampling Studies
MH  - Time Factors
MH  - Tissue Donors
MH  - Transplantation, Homologous/adverse effects/methods
PMC - PMC7950141
OTO - NOTNLM
OT  - Allogeneic transplantation
OT  - Hand
OT  - Rehabilitation
EDAT- 2015/10/21 06:00
MHDA- 2017/07/20 06:00
PMCR- 2015/10/20
CRDT- 2015/10/21 06:00
PHST- 2015/06/29 00:00 [received]
PHST- 2015/09/20 00:00 [accepted]
PHST- 2015/10/21 06:00 [pubmed]
PHST- 2017/07/20 06:00 [medline]
PHST- 2015/10/21 06:00 [entrez]
PHST- 2015/10/20 00:00 [pmc-release]
AID - IWJ12520 [pii]
AID - 10.1111/iwj.12520 [doi]
PST - ppublish
SO  - Int Wound J. 2016 Dec;13(6):1303-1308. doi: 10.1111/iwj.12520. Epub 2015 Oct 20.