PMID- 26481819 OWN - NLM STAT- MEDLINE DCOM- 20160317 LR - 20240324 IS - 1549-4713 (Electronic) IS - 0161-6420 (Print) IS - 0161-6420 (Linking) VI - 122 IP - 12 DP - 2015 Dec TI - Ultrahigh-Speed, Swept-Source Optical Coherence Tomography Angiography in Nonexudative Age-Related Macular Degeneration with Geographic Atrophy. PG - 2532-44 LID - S0161-6420(15)00885-4 [pii] LID - 10.1016/j.ophtha.2015.08.029 [doi] AB - PURPOSE: To investigate ultrahigh-speed, swept-source optical coherence tomography (SSOCT) angiography for visualizing vascular changes in eyes with nonexudative age-related macular degeneration (AMD) with geographic atrophy (GA). DESIGN: Observational, prospective, cross-sectional study. PARTICIPANTS: A total of 63 eyes from 32 normal subjects and 12 eyes from 7 patients with nonexudative AMD with GA. METHODS: A 1050-nm, 400-kHz A-scan rate SSOCT system was used to perform volumetric optical coherence tomography angiography (OCTA) of the retinal and choriocapillaris (CC) vasculatures in normal subjects and patients with nonexudative AMD with GA. Optical coherence tomography angiography using variable interscan time analysis (VISTA) was performed to assess CC alteration and differentiate varying degrees of CC flow impairment. MAIN OUTCOME MEASURES: Qualitative comparison of retinal and CC vasculatures in normal subjects versus those in patients with a clinical diagnosis of nonexudative AMD with GA. RESULTS: In all 12 eyes with GA, OCTA showed pronounced CC flow impairment within the region of GA. In 10 of the 12 eyes with GA, OCTA with VISTA showed milder CC flow impairment extending beyond the margin of GA. Of the 5 eyes exhibiting foveal-sparing GA, OCTA showed CC flow within the region of foveal sparing in 4 of the eyes. CONCLUSIONS: The ability of ultrahigh-speed, swept-source OCTA to noninvasively visualize alterations in the retinal and CC vasculatures makes it a promising tool for assessing nonexudative AMD with GA. Optical coherence tomography angiography using VISTA can distinguish varying degrees of CC alteration and flow impairment and may be useful for elucidating disease pathogenesis, progression, and response to therapy. CI - Copyright (c) 2015 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved. FAU - Choi, WooJhon AU - Choi W AD - Department of Electrical Engineering and Computer Science, and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts. FAU - Moult, Eric M AU - Moult EM AD - Department of Electrical Engineering and Computer Science, and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts; Division of Health Sciences and Technology, Harvard-Massachusetts Institute of Technology, Cambridge, Massachusetts. FAU - Waheed, Nadia K AU - Waheed NK AD - New England Eye Center, Tufts University Medical Center, Boston, Massachusetts. FAU - Adhi, Mehreen AU - Adhi M AD - New England Eye Center, Tufts University Medical Center, Boston, Massachusetts. FAU - Lee, ByungKun AU - Lee B AD - Department of Electrical Engineering and Computer Science, and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts. FAU - Lu, Chen D AU - Lu CD AD - Department of Electrical Engineering and Computer Science, and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts. FAU - de Carlo, Talisa E AU - de Carlo TE AD - New England Eye Center, Tufts University Medical Center, Boston, Massachusetts. FAU - Jayaraman, Vijaysekhar AU - Jayaraman V AD - Praevium Research Inc., Santa Barbara, California. FAU - Rosenfeld, Philip J AU - Rosenfeld PJ AD - Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida. FAU - Duker, Jay S AU - Duker JS AD - New England Eye Center, Tufts University Medical Center, Boston, Massachusetts. FAU - Fujimoto, James G AU - Fujimoto JG AD - Department of Electrical Engineering and Computer Science, and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts. Electronic address: jgfuji@mit.edu. LA - eng GR - R44-EY022864-01/EY/NEI NIH HHS/United States GR - R44 EY022864/EY/NEI NIH HHS/United States GR - R01 CA075289/CA/NCI NIH HHS/United States GR - R01-EY011289-27/EY/NEI NIH HHS/United States GR - R01-CA075289-16/CA/NCI NIH HHS/United States GR - R44-EY022864-02/EY/NEI NIH HHS/United States GR - R01 EY011289/EY/NEI NIH HHS/United States PT - Journal Article PT - Observational Study PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, Non-P.H.S. DEP - 20151017 PL - United States TA - Ophthalmology JT - Ophthalmology JID - 7802443 SB - IM MH - Adult MH - Aged MH - Aged, 80 and over MH - Blood Flow Velocity MH - Choroid/*blood supply MH - Cross-Sectional Studies MH - Female MH - Fluorescein Angiography MH - Geographic Atrophy/diagnosis/*physiopathology MH - Humans MH - Macular Degeneration/diagnosis/*physiopathology MH - Male MH - Middle Aged MH - Prospective Studies MH - Regional Blood Flow MH - Retinal Vessels/*pathology MH - Tomography, Optical Coherence PMC - PMC4658257 MID - NIHMS719307 EDAT- 2015/10/21 06:00 MHDA- 2016/03/18 06:00 PMCR- 2016/12/01 CRDT- 2015/10/21 06:00 PHST- 2015/04/21 00:00 [received] PHST- 2015/08/13 00:00 [revised] PHST- 2015/08/24 00:00 [accepted] PHST- 2015/10/21 06:00 [entrez] PHST- 2015/10/21 06:00 [pubmed] PHST- 2016/03/18 06:00 [medline] PHST- 2016/12/01 00:00 [pmc-release] AID - S0161-6420(15)00885-4 [pii] AID - 10.1016/j.ophtha.2015.08.029 [doi] PST - ppublish SO - Ophthalmology. 2015 Dec;122(12):2532-44. doi: 10.1016/j.ophtha.2015.08.029. Epub 2015 Oct 17.