PMID- 26482573
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20220408
IS  - 1530-8022 (Electronic)
IS  - 0885-3282 (Linking)
VI  - 30
IP  - 7
DP  - 2016 Feb
TI  - Intermittent administration of human parathyroid hormone (1-34) increases 
      fixation of strontium-doped hydroxyapatite coating titanium implants via 
      electrochemical deposition in ovariectomized rat femur.
PG  - 952-60
LID - 10.1177/0885328215610898 [doi]
AB  - Previous studies have demonstrated the effect of human parathyroid hormone (1-34) 
      (PTH) or strontium-doped hydroxyapatite coating (Sr-HA) on osteoporotic bone 
      implantation. However, reports about effects of PTH plus Sr-HA on bone 
      osseointegration of titanium implants in a state of osteoporosis were limited. 
      This study was designed to investigate the effects of intermittent administration 
      of human parathyroid hormone (1-34) on strontium-doped hydroxyapatite coating 
      (Sr-HA) implant fixation in ovariectomized (OVX) rats. Twelve weeks after 
      bilateral ovariectomy, all animals were randomly divided into four groups 
      including control group, Sr group, PTH group and PTH+Sr group. Forty OVX rats 
      accepted implant insertion in the distal femurs, control group, and PTH group 
      with HA implants and the Sr group and PTH+Sr group with Sr-HA implants. Animals 
      from PTH group and PTH+Sr group then randomly received PTH (60 microg/kg, 3 times a 
      week) until death at 12 weeks. After 12-week healing period, implants from group 
      PTH+Sr revealed improved osseointegration compared with other treatment groups, 
      which is manifested by the exceeding increase of bone area ratio and 
      bone-to-implant contact, the trabecular microarchitecture and the maximal 
      push-out force displayed by tests like histomorphometry, micro-CT, and 
      biomechanics evaluation. These results demonstrated that PTH+ Sr-HA coatings 
      could enhance implant osseointegration in OVX rats, and suggested the feasibility 
      of using this method to improve implant fixation in osteoporotic bone.
CI  - (c) The Author(s) 2015.
FAU - Tao, Zhou-Shan
AU  - Tao ZS
AD  - Department of Orthopaedic Surgery, Second Affiliated Hospital of Wenzhou Medical 
      University, Zhejiang, PR China.
FAU - Zhou, Wan-Shu
AU  - Zhou WS
AD  - Endocrine & Metabolic Diseases Unit, Affiliated Hospital of Guizhou Medcial 
      University, Guizhou, PR China.
FAU - Qiang, Zhou
AU  - Qiang Z
AD  - Department of Orthopaedic Surgery, Second Affiliated Hospital of Wenzhou Medical 
      University, Zhejiang, PR China.
FAU - Tu, Kai-kai
AU  - Tu KK
AD  - Department of Orthopaedic Surgery, Second Affiliated Hospital of Wenzhou Medical 
      University, Zhejiang, PR China.
FAU - Huang, Zheng-Liang
AU  - Huang ZL
AD  - Department of Orthopaedic Surgery, Second Affiliated Hospital of Wenzhou Medical 
      University, Zhejiang, PR China.
FAU - Xu, Hong-Ming
AU  - Xu HM
AD  - Department of Orthopaedic Surgery, Second Affiliated Hospital of Wenzhou Medical 
      University, Zhejiang, PR China.
FAU - Sun, Tao
AU  - Sun T
AD  - Department of Orthopaedic Surgery, Second Affiliated Hospital of Wenzhou Medical 
      University, Zhejiang, PR China.
FAU - Lv, Yang-Xun
AU  - Lv YX
AD  - Department of Orthopaedic Surgery, Wenzhou Central Hospital, Wenzhou, Zhejiang, 
      PR China.
FAU - Cui, Wei
AU  - Cui W
AD  - Sichuan Provincial Orthopedics Hospital, Sichuan, PR China.
FAU - Yang, Lei
AU  - Yang L
AD  - Department of Orthopaedic Surgery, Second Affiliated Hospital of Wenzhou Medical 
      University, Zhejiang, PR China tzs19900327@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151018
PL  - England
TA  - J Biomater Appl
JT  - Journal of biomaterials applications
JID - 8813912
RN  - 0 (Bone Density Conservation Agents)
RN  - 0 (Bone Substitutes)
RN  - 0 (Coated Materials, Biocompatible)
RN  - 0 (Hydroxyapatites)
RN  - 0 (PTH protein, human)
RN  - 0 (Parathyroid Hormone)
RN  - 0 (strontium hydroxyapatite)
RN  - 91D9GV0Z28 (Durapatite)
RN  - D1JT611TNE (Titanium)
RN  - YZS2RPE8LE (Strontium)
SB  - IM
MH  - Animals
MH  - Biomechanical Phenomena
MH  - Bone Density Conservation Agents/chemistry
MH  - Bone Substitutes/*chemistry
MH  - Bone and Bones/pathology
MH  - Coated Materials, Biocompatible/chemistry
MH  - Durapatite/*chemistry
MH  - Electrochemistry
MH  - Female
MH  - Femur/*pathology
MH  - Humans
MH  - Hydroxyapatites/*chemistry
MH  - Materials Testing
MH  - Osseointegration
MH  - Osteoporosis/drug therapy/physiopathology
MH  - Parathyroid Hormone/*administration & dosage/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Stress, Mechanical
MH  - Strontium/*chemistry
MH  - Titanium/*chemistry
MH  - X-Ray Microtomography
OTO - NOTNLM
OT  - Osteoporosis
OT  - hydroxyapatite-coated titanium implants
OT  - osseointegration
OT  - parathyroid hormone (1-34)
OT  - strontium
EDAT- 2015/10/21 06:00
MHDA- 2016/12/15 06:00
CRDT- 2015/10/21 06:00
PHST- 2015/10/21 06:00 [entrez]
PHST- 2015/10/21 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - 0885328215610898 [pii]
AID - 10.1177/0885328215610898 [doi]
PST - ppublish
SO  - J Biomater Appl. 2016 Feb;30(7):952-60. doi: 10.1177/0885328215610898. Epub 2015 
      Oct 18.