PMID- 26484029
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151020
LR  - 20220316
IS  - 2211-9132 (Print)
IS  - 2211-9140 (Electronic)
IS  - 2211-9132 (Linking)
VI  - 34
IP  - 2
DP  - 2015 Jun
TI  - Changes in serum magnesium concentration after use of a proton pump inhibitor in 
      patients undergoing percutaneous coronary intervention.
PG  - 98-102
LID - 10.1016/j.krcp.2015.03.001 [doi]
AB  - BACKGROUND: Although cross-sectional studies have suggested a relationship 
      between proton pump inhibitor (PPI) use and hypomagnesemia, no large-scale cohort 
      study has been conducted to date. Here, we examined the changes in serum 
      magnesium levels in response to PPI use. We hypothesized that PPI use might 
      change the serum magnesium concentration. METHODS: Of the 2,892 patients 
      hospitalized for percutaneous coronary intervention between January 2007 and May 
      2012, 1,076 patients with normal baseline (1.6-2.5 mg/dL) and follow-up serum 
      magnesium concentrations were enrolled. These patients were divided into two 
      groups: the PPI group and the control group. RESULTS: The mean follow-up period 
      was 9.51 +/- 2.94 months. The incidence of hypomagnesemia (< 1.6 mg/dL) was 0.4% 
      (3/834) in the PPI group and 0.4% (1/242) in the control group (P = 0.904). The 
      change in magnesium levels did not differ between the two groups, and this result 
      was maintained in the analysis of covariance after adjusting for confounding 
      factors (P = 0.381). Moreover, magnesium levels did not significantly differ 
      between the long-term (duration of use >/= 12 months, n = 71) and short-term PPI 
      groups (duration of use < 12 months, n = 763), and the control group (n = 242; 
      P = 0.620). The effect of PPI use on change in serum magnesium concentration was 
      affected by the use of multiple diuretics (-0.01 +/- 0.25 mg/dL; P = 0.025), 
      although a single diuretic use with PPI did not alter the change in magnesium 
      level (0.12 +/- 0.27 mg/dL). CONCLUSION: Changes in magnesium levels might be 
      subtle after PPI use in patients with normal baseline magnesium values.
FAU - Park, Sang-Ho
AU  - Park SH
AD  - Department of Internal medicine, Soonchunhyang University Cheonan Hospital, 
      Cheonan, Korea.
FAU - Lee, Sun-Hyo
AU  - Lee SH
AD  - Department of Internal medicine, Soonchunhyang University Cheonan Hospital, 
      Cheonan, Korea.
FAU - Lee, Ji-Sung
AU  - Lee JS
AD  - Biostatistical Consulting Unit, Soonchunhyang University Medical Center, Seoul, 
      Korea.
FAU - Shin, Won-Yong
AU  - Shin WY
AD  - Department of Internal medicine, Soonchunhyang University Cheonan Hospital, 
      Cheonan, Korea.
FAU - Gil, Hyo-Wook
AU  - Gil HW
AD  - Department of Internal medicine, Soonchunhyang University Cheonan Hospital, 
      Cheonan, Korea.
FAU - Yang, Jong-Oh
AU  - Yang JO
AD  - Department of Internal medicine, Soonchunhyang University Cheonan Hospital, 
      Cheonan, Korea.
FAU - Lee, Eun-Young
AU  - Lee EY
AD  - Department of Internal medicine, Soonchunhyang University Cheonan Hospital, 
      Cheonan, Korea.
FAU - Hong, Sae-Yong
AU  - Hong SY
AD  - Department of Internal medicine, Soonchunhyang University Cheonan Hospital, 
      Cheonan, Korea.
LA  - eng
PT  - Journal Article
DEP - 20150327
PL  - Korea (South)
TA  - Kidney Res Clin Pract
JT  - Kidney research and clinical practice
JID - 101586778
PMC - PMC4570593
OTO - NOTNLM
OT  - Diuretics
OT  - Magnesium
OT  - Proton pump inhibitor
EDAT- 2015/10/21 06:00
MHDA- 2015/10/21 06:01
PMCR- 2015/03/27
CRDT- 2015/10/21 06:00
PHST- 2015/01/05 00:00 [received]
PHST- 2015/02/19 00:00 [revised]
PHST- 2015/03/14 00:00 [accepted]
PHST- 2015/10/21 06:00 [entrez]
PHST- 2015/10/21 06:00 [pubmed]
PHST- 2015/10/21 06:01 [medline]
PHST- 2015/03/27 00:00 [pmc-release]
AID - S2211-9132(15)00012-1 [pii]
AID - 10.1016/j.krcp.2015.03.001 [doi]
PST - ppublish
SO  - Kidney Res Clin Pract. 2015 Jun;34(2):98-102. doi: 10.1016/j.krcp.2015.03.001. 
      Epub 2015 Mar 27.