PMID- 26484192
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151020
LR  - 20201001
IS  - 2213-5960 (Print)
IS  - 2213-5960 (Electronic)
IS  - 2213-5960 (Linking)
VI  - 4
DP  - 2015 Jun
TI  - Toxicogenomic analysis of placenta samples from mice exposed to different doses 
      of BPA.
PG  - 109-11
LID - 10.1016/j.gdata.2015.04.004 [doi]
AB  - Bisphenol A (BPA), a widespread Endocrine Disrupter mainly used in food contact 
      plastics, may induce adverse effects especially on susceptible lifestages, first 
      of all pregnancy. The present study considered placental development as a 
      potential target of BPA and investigated potential differences in the modes of 
      action of two doses of BPA by a toxicogenomic approach. Pregnant CD-1 mice were 
      administered with vehicle, 0.5 (BPA05) or 50 mg/kg (BPA50) body weight (bw)/die 
      of BPA, from gestational day (GD) 1 to GD11. At GD12 dams were sacrificed and 
      transcriptomic analysis was performed on placenta samples. Histological, 
      histomorphometrical and immunohistochemical analyses were also performed to 
      phenotypically anchor transcriptional changes associated with BPA exposure. The 
      interpretation and description of the overall data are included in a manuscript 
      under revision [1]. Here we describe the experimental design and the analysis 
      performed on the gene expression data which are publicly available through the 
      Gene Expression Omnibus (GEO) database with accession number GSE63852.
FAU - Tait, Sabrina
AU  - Tait S
AD  - Food and Veterinary Toxicology Unit, Dept. Veterinary Public Health and Food 
      Safety, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy.
FAU - Tassinari, Roberta
AU  - Tassinari R
AD  - Food and Veterinary Toxicology Unit, Dept. Veterinary Public Health and Food 
      Safety, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy.
FAU - Maranghi, Francesca
AU  - Maranghi F
AD  - Food and Veterinary Toxicology Unit, Dept. Veterinary Public Health and Food 
      Safety, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy.
FAU - Mantovani, Alberto
AU  - Mantovani A
AD  - Food and Veterinary Toxicology Unit, Dept. Veterinary Public Health and Food 
      Safety, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy.
LA  - eng
PT  - Journal Article
DEP - 20150411
PL  - United States
TA  - Genom Data
JT  - Genomics data
JID - 101634120
PMC - PMC4536010
OTO - NOTNLM
OT  - Bisphenol A
OT  - Developmental toxicity
OT  - Endocrine disruption
OT  - Placenta
OT  - Toxicogenomics
EDAT- 2015/10/21 06:00
MHDA- 2015/10/21 06:01
PMCR- 2015/04/11
CRDT- 2015/10/21 06:00
PHST- 2015/03/26 00:00 [received]
PHST- 2015/04/03 00:00 [revised]
PHST- 2015/04/03 00:00 [accepted]
PHST- 2015/10/21 06:00 [entrez]
PHST- 2015/10/21 06:00 [pubmed]
PHST- 2015/10/21 06:01 [medline]
PHST- 2015/04/11 00:00 [pmc-release]
AID - S2213-5960(15)00038-0 [pii]
AID - 10.1016/j.gdata.2015.04.004 [doi]
PST - epublish
SO  - Genom Data. 2015 Apr 11;4:109-11. doi: 10.1016/j.gdata.2015.04.004. eCollection 
      2015 Jun.