PMID- 26484340
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151020
LR  - 20200930
IS  - 2296-2565 (Print)
IS  - 2296-2565 (Electronic)
IS  - 2296-2565 (Linking)
VI  - 3
DP  - 2015
TI  - Interferon Gamma-Based Detection of Latent Tuberculosis Infection in the Border 
      States of Nuevo Leon and Tamaulipas, Mexico.
PG  - 220
LID - 10.3389/fpubh.2015.00220 [doi]
LID - 220
AB  - Nearly one-third of the world's population is infected with latent tuberculosis 
      (LTBI). Tuberculosis (TB) rates in the border states are higher than national 
      rates in both the US and Mexico, with the border accounting for 30% of total 
      registered TB cases in both countries. However, LTBI rates in the general 
      population in Mexican border states are unknown. In this region, LTBI is 
      diagnosed using the tuberculin skin test (TST). New methods of detection more 
      specific than TST have been developed, although there is currently no gold 
      standard for LTBI detection. Our objective is to demonstrate utility of the 
      Quantiferon TB gold In-Tube (QFT-GIT) test compared with the TST to detect LTBI 
      among border populations. This is an observational, cross-sectional study carried 
      out in border areas of the states of Nuevo Leon and Tamaulipas, Mexico. 
      Participants (n = 210) provided a TST and blood sample for the QFT-GIT. Kappa 
      coefficients assessed the agreement between TST and QFT-GIT. Participant 
      characteristics were compared using Fisher exact tests. Thirty-eight percent of 
      participants were diagnosed with LTBI by QFT-GIT. The proportion of LTBI detected 
      using QFT-GIT was almost double [38% (79/210)] that found by TST [19% (39/210)] 
      (P < 0.001). Concordance between TST and QFT-GIT was low (kappa = 0.37). We 
      recommend further studies utilizing the QFT-GIT test to detect LTBI among border 
      populations.
FAU - Oren, Eyal
AU  - Oren E
AD  - Division of Epidemiology and Biostatistics, University of Arizona , Tucson, AZ , 
      USA.
FAU - Alatorre-Izaguirre, Gabriela
AU  - Alatorre-Izaguirre G
AD  - Health Division, Basic Sciences, University of Monterrey , San Pedro Garza Garcia 
      , Mexico.
FAU - Vargas-Villarreal, Javier
AU  - Vargas-Villarreal J
AD  - Ministry of Health Tamaulipas , Ciudad Victoria , Mexico.
FAU - Moreno-Trevino, Maria Guadalupe
AU  - Moreno-Trevino MG
AD  - Health Division, Basic Sciences, University of Monterrey , San Pedro Garza Garcia 
      , Mexico.
FAU - Garcialuna-Martinez, Javier
AU  - Garcialuna-Martinez J
AD  - Ministry of Health Tamaulipas , Ciudad Victoria , Mexico.
FAU - Gonzalez-Salazar, Francisco
AU  - Gonzalez-Salazar F
AD  - Health Division, Basic Sciences, University of Monterrey , San Pedro Garza Garcia 
      , Mexico ; Northeast Biomedical Research, Mexican Social Security Institute , 
      Monterrey , Mexico.
LA  - eng
PT  - Journal Article
DEP - 20150930
PL  - Switzerland
TA  - Front Public Health
JT  - Frontiers in public health
JID - 101616579
PMC - PMC4588115
OTO - NOTNLM
OT  - Mexico
OT  - Mycobacterium tuberculosis
OT  - interferon gamma
OT  - latent tuberculosis infection
OT  - tuberculin skin test
OT  - tuberculosis
EDAT- 2015/10/21 06:00
MHDA- 2015/10/21 06:01
PMCR- 2015/09/30
CRDT- 2015/10/21 06:00
PHST- 2015/03/13 00:00 [received]
PHST- 2015/09/17 00:00 [accepted]
PHST- 2015/10/21 06:00 [entrez]
PHST- 2015/10/21 06:00 [pubmed]
PHST- 2015/10/21 06:01 [medline]
PHST- 2015/09/30 00:00 [pmc-release]
AID - 10.3389/fpubh.2015.00220 [doi]
PST - epublish
SO  - Front Public Health. 2015 Sep 30;3:220. doi: 10.3389/fpubh.2015.00220. 
      eCollection 2015.