PMID- 26486098
OWN - NLM
STAT- MEDLINE
DCOM- 20170104
LR  - 20181113
IS  - 1751-7893 (Electronic)
IS  - 1751-7885 (Print)
IS  - 1751-7885 (Linking)
VI  - 10
IP  - 3
DP  - 2016 Jun
TI  - Adolescents with or at ultra-high risk for bipolar disorder exhibit erythrocyte 
      docosahexaenoic acid and eicosapentaenoic acid deficits: a candidate prodromal 
      risk biomarker.
PG  - 203-11
LID - 10.1111/eip.12282 [doi]
AB  - AIM: Mood disorders are associated with low levels of the long-chain omega-3 
      (LCn-3) fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). 
      This study investigated LCn-3 fatty acid biostatus in youth with or at varying 
      risk for developing mania to assess its utility as a prodromal risk biomarker. 
      METHOD: Erythrocyte fatty acid composition was determined in healthy adolescents 
      (n = 28, HC), asymptomatic adolescents with a biological parent with bipolar I 
      disorder (n = 30; 'high risk', HR), adolescents with a biological parent with 
      bipolar I disorder and major depressive disorder, or depressive disorder not 
      otherwise specified (n = 36; 'ultra-high risk', UHR), and first-episode 
      adolescent bipolar manic patients (n = 35, BP). RESULTS: Group differences were 
      observed for DHA (P </= 0.0001) and EPA (P = 0.03). Compared with HC, erythrocyte 
      EPA + DHA ('omega-3 index') was significantly lower in BP (-24%, P </= 0.0001) and 
      UHR (-19%, P = 0.0006) groups, and there was a trend in the HR group (-11%, 
      P = 0.06). Compared with HC (61%), a greater percentage of HR (77%, P = 0.02), 
      UHR (80%, P = 0.005) and BP (97%, P = 0.001) subjects exhibited EPA + DHA levels 
      of </=4.0%. Among all subjects (n = 130), EPA + DHA was inversely correlated with 
      manic (r = -0.29, P = 0.0008) and depressive (r = -0.28, P = 0.003) symptom 
      severity. The AA/EPA + DHA ratio was significantly greater in BP (+22%, 
      P = 0.0002) and UHR (+16%, P = 0.001) groups. CONCLUSIONS: Low EPA + DHA levels 
      coincide with the initial onset of mania, and increasing risk for developing 
      bipolar disorder is associated with graded erythrocyte EPA + DHA deficits. Low 
      erythrocyte EPA + DHA biostatus may represent a promising prodromal risk 
      biomarker warranting additional evaluation in future prospective studies.
CI  - (c) 2015 Wiley Publishing Asia Pty Ltd.
FAU - McNamara, Robert K
AU  - McNamara RK
AD  - Department of Psychiatry and Behavioral Neuroscience, Division of Bipolar 
      Disorders Research, University of Cincinnati College of Medicine, Cincinnati, 
      Ohio, USA.
FAU - Jandacek, Ronald
AU  - Jandacek R
AD  - Department of Pathology, University of Cincinnati, Cincinnati, Ohio, USA.
FAU - Tso, Patrick
AU  - Tso P
AD  - Department of Pathology, University of Cincinnati, Cincinnati, Ohio, USA.
FAU - Blom, Thomas J
AU  - Blom TJ
AD  - Department of Psychiatry and Behavioral Neuroscience, Division of Bipolar 
      Disorders Research, University of Cincinnati College of Medicine, Cincinnati, 
      Ohio, USA.
FAU - Welge, Jeffrey A
AU  - Welge JA
AD  - Department of Psychiatry and Behavioral Neuroscience, Division of Bipolar 
      Disorders Research, University of Cincinnati College of Medicine, Cincinnati, 
      Ohio, USA.
FAU - Strawn, Jeffrey R
AU  - Strawn JR
AD  - Department of Psychiatry and Behavioral Neuroscience, Division of Bipolar 
      Disorders Research, University of Cincinnati College of Medicine, Cincinnati, 
      Ohio, USA.
FAU - Adler, Caleb M
AU  - Adler CM
AD  - Department of Psychiatry and Behavioral Neuroscience, Division of Bipolar 
      Disorders Research, University of Cincinnati College of Medicine, Cincinnati, 
      Ohio, USA.
FAU - Strakowski, Stephen M
AU  - Strakowski SM
AD  - Department of Psychiatry and Behavioral Neuroscience, Division of Bipolar 
      Disorders Research, University of Cincinnati College of Medicine, Cincinnati, 
      Ohio, USA.
FAU - DelBello, Melissa P
AU  - DelBello MP
AD  - Department of Psychiatry and Behavioral Neuroscience, Division of Bipolar 
      Disorders Research, University of Cincinnati College of Medicine, Cincinnati, 
      Ohio, USA.
LA  - eng
GR  - R01 DK097599/DK/NIDDK NIH HHS/United States
GR  - R34 MH083924/MH/NIMH NIH HHS/United States
GR  - MH080973/MH/NIMH NIH HHS/United States
GR  - DK59630/DK/NIDDK NIH HHS/United States
GR  - R01 MH080973/MH/NIMH NIH HHS/United States
GR  - MH083924/MH/NIMH NIH HHS/United States
GR  - P50 MH077138/MH/NIMH NIH HHS/United States
GR  - UL1 TR001425/TR/NCATS NIH HHS/United States
GR  - U24 DK059630/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20151020
PL  - Australia
TA  - Early Interv Psychiatry
JT  - Early intervention in psychiatry
JID - 101320027
RN  - 0 (Biomarkers)
RN  - 25167-62-8 (Docosahexaenoic Acids)
RN  - AAN7QOV9EA (Eicosapentaenoic Acid)
SB  - IM
CIN - Early Interv Psychiatry. 2016 Jun;10(3):191-2. PMID: 27037962
MH  - Adolescent
MH  - Biomarkers/metabolism
MH  - Bipolar Disorder/metabolism
MH  - Case-Control Studies
MH  - Child
MH  - Docosahexaenoic Acids/*deficiency
MH  - Eicosapentaenoic Acid/*metabolism
MH  - Erythrocytes/*metabolism
MH  - Female
MH  - Humans
MH  - Male
MH  - *Prodromal Symptoms
MH  - Risk Factors
MH  - Young Adult
PMC - PMC4818707
MID - NIHMS725792
OTO - NOTNLM
OT  - arachidonic acid (AA)
OT  - eicosapentaenoic acid (EPA)
OT  - mania
OT  - omega-3 index
OT  - ultra-high risk
EDAT- 2015/10/22 06:00
MHDA- 2017/01/05 06:00
PMCR- 2017/06/01
CRDT- 2015/10/22 06:00
PHST- 2015/08/23 00:00 [received]
PHST- 2015/09/21 00:00 [accepted]
PHST- 2015/10/22 06:00 [entrez]
PHST- 2015/10/22 06:00 [pubmed]
PHST- 2017/01/05 06:00 [medline]
PHST- 2017/06/01 00:00 [pmc-release]
AID - 10.1111/eip.12282 [doi]
PST - ppublish
SO  - Early Interv Psychiatry. 2016 Jun;10(3):203-11. doi: 10.1111/eip.12282. Epub 2015 
      Oct 20.