PMID- 2648634
OWN - NLM
STAT- MEDLINE
DCOM- 19890428
LR  - 20071114
IS  - 0040-3709 (Print)
IS  - 0040-3709 (Linking)
VI  - 39
IP  - 2
DP  - 1989 Feb
TI  - Evaluation of the bioeffects of prenatal ultrasound exposure in the cynomolgus 
      macaque (Macaca fascicularis): I. Neonatal/infant observations.
PG  - 137-47
AB  - The frequency of use of ultrasonography for evaluating the developing 
      embryo/fetus has continued to rise although the possible risks from exposure 
      still remain uncertain. The cynomolgus macaque (Macaca fascicularis) is currently 
      being used in our laboratory as a model to assess these risks. In utero exposure 
      was performed utilizing a commercial real-time mechanical sector scanner with a 
      7.5 MHz scanhead (ATL, MK 600). Maximum acoustic power output for this unit is as 
      follows: I(SPTA) = 12.0 mW/cm2, I(SPPA) = 98 W/cm2, and Im = 137 W/cm2. Animals 
      exposed to ultrasound (N = 16) were scanned five times weekly on gestational days 
      (GD) 21-35 +/- 2 for 10 minutes/exam (m/e), three times weekly on GD 36-60 +/- 2 
      for 10 m/e, and once weekly on GD 61-150 +/- 2 for 20 m/e. Controls (N = 14) were 
      "scanned" with the unit placed on standby. Assessment of simian Apgar scores at 
      1, 5, and 10 minutes of life revealed higher scores for treated animals at 10 
      minutes (P less than or equal to 0.045); greater scores in muscle tone (P less 
      than or equal to 0.013) and color (P less than or equal to 0.016) were observed. 
      Evaluation of morphometrics at birth including weight, biparietal diameter, 
      occipitofrontal diameter, head circumference, hand and foot lengths, humerus and 
      femur lengths, arm circumference, chest circumference, tail length, skinfold 
      thickness, and crown-rump length (CRL) indicated a significant reduction in only 
      two parameters, birth weight (P less than or equal to 0.027) and CRL (P less than 
      or equal to 0.033). Hematologic analysis at 2 +/- 1, 9 +/- 1, and 16 +/- 1 days 
      of life revealed a significant difference in white blood cell counts (WBCs). 
      Treated animals displayed lower WBCs with reductions in numbers of segmented 
      neutrophils and monocytes at all ages observed. Hematologic differences were not 
      significant by 5-6 months of age. No abortions, gross malformations, or 
      stillbirths were observed in the exposed animals.
FAU - Tarantal, A F
AU  - Tarantal AF
AD  - California Primate Research Center, University of California, Davis 95616.
FAU - Hendrickx, A G
AU  - Hendrickx AG
LA  - eng
GR  - RR00169/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Teratology
JT  - Teratology
JID - 0153257
SB  - IM
MH  - Animals
MH  - Anthropometry
MH  - Birth Weight
MH  - Female
MH  - Fetal Monitoring/*adverse effects
MH  - Hematologic Tests
MH  - Leukocyte Count
MH  - Macaca fascicularis
MH  - Pregnancy
MH  - Ultrasonography/*adverse effects
EDAT- 1989/02/01 00:00
MHDA- 1989/02/01 00:01
CRDT- 1989/02/01 00:00
PHST- 1989/02/01 00:00 [pubmed]
PHST- 1989/02/01 00:01 [medline]
PHST- 1989/02/01 00:00 [entrez]
AID - 10.1002/tera.1420390206 [doi]
PST - ppublish
SO  - Teratology. 1989 Feb;39(2):137-47. doi: 10.1002/tera.1420390206.